BEGIN:VCALENDAR
PRODID:-//eluceo/ical//2.0/EN
VERSION:2.0
CALSCALE:GREGORIAN
BEGIN:VEVENT
UID:67ea4f9c959132aab8515a5c2f159535
DTSTAMP:20261011T031611Z
SUMMARY:Filippo Menolascina (Edinburgh): From gene networks to behaviours
DESCRIPTION:With the recent demonstration of real-time gene networks contro
 l in-vivo\, new opportunities became available to Control Engineers to con
 tribute to the development of new and exciting results at the boundary of 
 Systems and Synthetic Biology. In this talk I will discuss how I took adva
 ntage of the lessons learnt while working on the control of synthetic gene
  circuits to regulate a bacterial behavioural trait stemming from a well k
 nown signalling pathway\, namely aerotaxis (i.e. the migration of microorg
 anisms in response to oxygen gradients). To this aim I will first present 
 two modelling approaches I used to quantitatively describe this behaviour 
 starting from high-throughput experimental data: (a) one based on Systems 
 Identification principles and (b) the other deeply rooted in the biophysic
 s of the intracellular signal transduction that mediates aerotaxis in my m
 odel system\, i.e. Bacillus subtilis. I will then show how the information
  obtained in this process enabled both (a) the discovery of a peculiar dyn
 amical property (i.e. logarithmic-sensing) B. subtilis might use to optimi
 ze its search for oxygen and (b) to achieve in-vivo positioning control of
  bacterial populations in microfluidic devices. I will then conclude discu
 ssing some of the efforts currently ongoing in my group to expand these re
 sults and adapt the closed loop approach I previously developed to impleme
 nt a real-time model-discrimination algorithm in-vivo.
URL:https://www.imperial.ac.uk/events/101135/filippo-menolascina-edinburgh-
 from-gene-networks-to-behaviours/
DTSTART;TZID=Europe/London:20170131T130000
DTEND;TZID=Europe/London:20170131T140000
LOCATION:United Kingdom
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:STANDARD
DTSTART:20170131T130000
TZNAME:GMT
TZOFFSETTO:+0000
TZOFFSETFROM:+0000
END:STANDARD
END:VTIMEZONE
END:VCALENDAR