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SUMMARY:In pursuit of a universal\, biomimetic iBCI decoder: Exploring the 
 manifold representations of action in the motor cortex (hybrid event)
DESCRIPTION:View the seminar recording here (Imperial College members only
 ) or contact k.hobson@imperial.ac.uk to request access.\nCentre for Neur
 otechnology seminar from Lee Miller\nProfessor of Neuroscience\, Northwest
 ern University\n\nIn pursuit of a universal\, biomimetic iBCI decoder: Exp
 loring the manifold representations of action in the motor cortex\nAbstrac
 t: My group pioneered the development of a novel intracortical brain compu
 ter interface (iBCI) that decodes muscle activity (EMG) from signals recor
 ded in the motor cortex of animals. We use these synthetic EMG signals to 
 control Functional Electrical Stimulation (FES)\, which causes the muscles
  to contract and thereby restores rudimentary voluntary control of the par
 alyzed limb. In the past few years\, there has been much interest in the f
 act that information from the millions of neurons active during movement c
 an be reduced to a small number of “latent” signals in a low-dimension
 al manifold computed from the multiple neuron recordings. These signals ca
 n be used to provide a stable prediction of the animal’s behavior over m
 any months-long periods\, and they may also provide the means to implement
  methods of transfer learning across individuals\, an application that cou
 ld be of particular importance for paralyzed human users. We have begun to
  examine the representation within this latent space\, of a broad range of
  behaviors\, including well-learned\, stereotyped movements in the lab\, a
 nd more natural movements in the animal’s home cage\, meant to better re
 present a person’s daily activities. We intend to develop an FES-based i
 BCI that will restore voluntary movement across a broad range of motor tas
 ks without need for intermittent recalibration. However\, the nonlineariti
 es and context dependence within this low-dimensional manifold present sig
 nificant challenges.\nBio: Lee E. Miller is a Distinguished Professor of N
 euroscience in the Departments of Neuroscience\, Physical Medicine and Reh
 abilitation\, and Biomedical Engineering at Northwestern University. He wa
 s inducted into the American Institute for Medical and Biological Engineer
 ing in 2016 and is the current president of the Society for the Neural Con
 trol of Movement. Dr. Miller has had a career-long interest in the brain
 ’s control of arm and hand movement\, which he has studied using both ps
 ychophysical and EMG experiments in humans\, and single neuron recordings 
 from behaving animals. In the past decade\, his lab has increasingly focus
 ed on translational research\, including the use of brain computer interfa
 ces designed to mimic the function of the intact nervous system in an effo
 rt to restore movement and sensation to spinal cord injured patients.\n\nW
 e invite you to attend in-person or online via Microsoft Teams. Please reg
 ister in advance so that we can confirm numbers. Those attending in person
  are invited to join the speaker for a sandwich lunch after the talk.\nJoi
 ning instructions for those attending remotely will be sent by email.
URL:https://www.imperial.ac.uk/events/145019/icneurotech-seminar-lee-miller
 /
DTSTART;TZID=Europe/London:20220520T120000
DTEND;TZID=Europe/London:20220520T130000
LOCATION:2.28\, Royal School Of Mines\, South Kensington Campus\, Imperial 
 College London\, London\, SW7 2AZ\, United Kingdom
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