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DTSTAMP:20261006T205522Z
SUMMARY:Fish Lost in Deep Time — The Evolutionary Origins and Mechanisms 
 of the Tetrapod Bodyplan
DESCRIPTION:Fish Lost in Deep Time — The Evolutionary Origins and Mechani
 sms of the Tetrapod Bodyplan\n\nTetsuya Nakamura\nRutgers the State Univer
 sity of New Jersey\n\nFinding the evolutionary origins of our body plan is
  a fundamental challenge in biology. Tetrapods acquired myriad evolutionar
 y innovations\, including the neck and limb\, during the transition from a
 quatic to terrestrial habitats. Despite the functional importance of these
  novel structures\, the extinction of transitional animals along the water
 -to-land axis has hindered our understanding of their evolutionary anteced
 ents and trajectories. Over the last several years\, by bridging functiona
 l genomics\, genetics\, and embryology\, our group has explored the ontoge
 netic and evolutionary origins of terrestrial limbs and shoulders within t
 he ray-finned fish body plan. We uncovered several critical genetic mechan
 isms underlying the development of functional appendages that meticulously
  coordinate skeletal\, muscular\, and neural development. Unexpectedly\, w
 e not only identified the genetic basis of functional limb development\, b
 ut also discovered a latent ability in fish to generate the pectoral morph
 ology akin to tetrapod digit bones\, shoulder girdle\, and neck. In this s
 eminar\, I introduce recent discoveries that reveal the deep conservation 
 of tetrapod locomotory organs through the long evolutionary journey of tet
 rapod ancestors and the mechanisms underlying their transformation.
URL:https://www.imperial.ac.uk/events/201918/fish-lost-in-deep-time-the-evo
 lutionary-origins-and-mechanisms-of-the-tetrapod-bodyplan/
DTSTART;TZID=Europe/London:20251120T130000
DTEND;TZID=Europe/London:20251120T140000
LOCATION:Birch/Oak Seminar Room\, Hamilton Building\, Silwood Park Campus\,
  Imperial College London\, Berkshire\, SL5 7PY\, United Kingdom
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