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SUMMARY:Eavesdropping on the brain: Fundamentally novel perspectives on psy
 chiatric diseases
DESCRIPTION:Eavesdropping on the brain: Fundamentally novel perspectives on
  psychiatric diseases with microengineered\, electrochemical detection pla
 tforms\nParry Hashemi\, Department of Bioengineering\, Imperial College Lo
 ndon\nAbstract\nDysfunctions of the brain’s serotonin system are thought
  to underlie the symptoms of depression\, primarily because antidepressant
 s that target the serotonin transporters show some clinical success. Howev
 er\, antidepressant efficacy is variable\, often delayed and temporary. Be
 cause the roles of serotonin in the brain during health and disease are il
 l-defined\, it is extremely challenging for drug developers to develop bet
 ter\, more targeted antidepressant therapies. This situation is confounded
  because current therapies assume that the serotonin system dysfunctions i
 n the same way regardless of the multitude of causes (psychological\, gene
 tic\, exposure\, disease) of human depression. In this work\, we develop a
 nd apply novel voltammetric tools and couple them with confocal imaging\, 
 animal behavior and mathematical models to characterize serotonin neurotra
 nsmission in different animal models of depression. Specifically we find t
 hat alterations in another neurotransmitter system\, the histamine system\
 , likely modulate abnormalities in the serotonin system. Additionally we f
 ind that rapid changes in serotonin transporter function may be responsibl
 e for the dosing and delayed therapeutic issues of common antidepressants.
  We model the experimental data and offer mechanistic insights into how hi
 stamine and serotonin modulate one another in health and disease and this 
 leads us to hypothesize why antidepressants are not universally effective.
  The data afforded by our chemical tools has the capacity to profoundly im
 prove therapeutic strategies towards depression by shedding light on anoth
 er important player.
URL:https://www.imperial.ac.uk/events/96349/eavesdropping-on-the-brain-fund
 amentally-novel-perspectives-on-psychiatric-diseases/
DTSTART;TZID=Europe/London:20191126T120000
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LOCATION:United Kingdom
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