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UID:39d5472df8b27a8b8d073be48ad11e7e
DTSTAMP:20261007T093341Z
SUMMARY:Responses to auxin signals: an operating principle for dynamical se
 nsitivity yet high resilience
DESCRIPTION:Title: Responses to auxin signals: an operating principle for d
 ynamical sensitivity yet high resilience\nSpeaker: Olivier Martin (GQE-Le 
 Moulon\, INRA\, Université Paris-Sud\, CNRS\, AgroParisTech\, Université
  Paris-Saclay\, Gif-sur-Yvette\, France)\n Abstract: Plants depend on the 
 signaling of the phytohormone auxin for their development and for respondi
 ng to environmental perturbations. The associated biomolecular signaling n
 etwork involves a negative feedback at the level of the Aux/IAA proteins w
 hich mediate the influence of auxin (the signal) on the ARF transcription 
 factors (the drivers of the response). To probe the role of this feedback\
 , we consider alternative in silico signaling networks implementing differ
 ent operating principles. By a comparative analysis\, we find that the pre
 sence of a negative regulatory feedback loop allows the system to have a f
 ar larger sensitivity in its dynamical response to auxin. At the same time
 \, this sensitivity does not prevent the system from being highly resilien
 t. Given this insight\, we reconsider previously published models and buil
 d a new quantitative and calibrated biomolecular model of auxin signaling.
   
URL:https://www.imperial.ac.uk/events/97119/responses-to-auxin-signals-an-o
 perating-principle-for-dynamical-sensitivity-yet-high-resilience/
DTSTART;TZID=Europe/London:20190514T130000
DTEND;TZID=Europe/London:20190514T140000
LOCATION:United Kingdom
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