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DTSTAMP:20260421T201221Z
SUMMARY:Understanding the robustness of morphogenesis using stochastic mech
 anical models of tissue growth
DESCRIPTION:Speaker: Professor Arezki Boudaoud (École Normale Supérieure 
 de Lyon (ENS de Lyon))\nAbstract: How do organs reach reproducible sizes a
 nd shapes in the face of substantial variability at the cellular level? Th
 e current belief is that a morphogen gradient spanning the organ provides 
 cells with positional information that controls organ size. Nevertheless\,
  recent evidence suggests that the simple interpretation of a global morph
 ogen gradient is insufficient for size control. We built a mechanical mode
 l for growth variability during the formation of 2D organs. This model con
 sists of a set of coupled  stochastic PDEs describing a viscous medium wi
 th spatially variable density and local nematic order\, each of which are 
 coupled to mechanical stress. We determined how variability changes across
  scales\, to understand how heterogeneous cells yield robust organs. These
  results may be compared to available experimental data.\n \n 
URL:https://www.imperial.ac.uk/events/97650/understanding-the-robustness-of
 -morphogenesis-using-stochastic-mechanical-models-of-tissue-growth/
DTSTART;TZID=Europe/London:20190312T130000
DTEND;TZID=Europe/London:20190312T140000
LOCATION:130\, Huxley Building\, South Kensington Campus\, Imperial College
  London\, London\, SW7 2AZ\, United Kingdom
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