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Journal articleBowcock AM, Cookson WOCM, 2004,
The genetics of psoriasis, psoriatic arthritis and atopic dermatitis
, Human Molecular Genetics, Vol: 13, ISSN: 0964-6906Psoriasis and atopic dermatitis are chronic and relapsing inflammatory diseases of the skin associated with various immunologic abnormalities. Approximately 30% of psoriasis patients also have joint involvement, indicative of psoriatic arthritis. Genes and environment play a key role in the pathogenesis of these diseases. Genome-wide linkage scans have identified multiple loci linked to each disease and revealed overlap with psoriasis and atopic dermatitis susceptibility loci on chromosomes 1q21, 3q21, 17q25 and 20p12. The genes from these loci have not yet all been identified, or systematically tested for a role in psoriasis and atopic dermatitis; however, these locations suggest that some susceptibility factors lie within genes or gene families with common effects upon epithelial immunity. A strong HLA association is described for psoriasis, but not for atopic dermatitis. Knowledge of the genetic factors leading to these diseases will lead to an understanding of their variable age at onset, their waxing and waning and the variability of body surface environment. The effect of environmental triggers may also be understood once the altered pathways are elucidated. Genes implicated so far in atopic dermatitis are SPINK5, FcERI-β and PHF11. Genes implicated in psoriasis so far are HLA-C, SLC9A3R1, NAT9, RAPTOR and SLC12A8. Genetic modifiers such as CARD15 may predispose to psoriatic arthritis. © Oxford University Press 2004; all rights reserved.
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Journal articleBowcock AM, Cookson WOCM, 2004,
The genetics of psoriasis, psoriatic arthritis and atopic dermatitis
, HUMAN MOLECULAR GENETICS, Vol: 13, Pages: R43-R55, ISSN: 0964-6906- Author Web Link
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- Citations: 197
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Journal articleHorsefield R, Iwata S, Byrne B, 2004,
Complex II from a structural perspective
, CURRENT PROTEIN & PEPTIDE SCIENCE, Vol: 5, Pages: 107-118, ISSN: 1389-2037- Author Web Link
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- Citations: 37
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Journal articleKoch A, Giembycz M, Ito K, et al., 2004,
Mitogen-activated protein kinase modulation of nuclear factor-KB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages
, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 30, Pages: 342-349, ISSN: 1044-1549- Author Web Link
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- Citations: 46
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Journal articleTanzer MM, Arst HN, Skalchunes AR, et al., 2004,
Global nutritional profiling for mutant and chemical mode-of-action analysis in filamentous fungi (vol3, pg 160, 2003)
, FUNCTIONAL & INTEGRATIVE GENOMICS, Vol: 4, Pages: 67-69, ISSN: 1438-793X -
Journal articleMoffatt MF, 2004,
SPINK5: a gene for atopic dermatitis and asthma.
, Clin Exp Allergy, Vol: 34, Pages: 325-327, ISSN: 0954-7894 -
Journal articleBarnes PJ, Ito K, Adcock IM, 2004,
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
, LANCET, Vol: 363, Pages: 731-733, ISSN: 0140-6736- Author Web Link
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- Citations: 280
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Journal articleIto K, Hanazawa T, Tomita K, et al., 2004,
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration
, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 315, Pages: 240-245, ISSN: 0006-291X- Author Web Link
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- Citations: 278
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Journal articleBismarck A, Boccaccini AR, Egia-Ajuriagojeaskoa E, et al., 2004,
Surface characterization of glass fibers made from silicate waste:: Zeta-potential and contact angle measurements
, JOURNAL OF MATERIALS SCIENCE, Vol: 39, Pages: 401-412, ISSN: 0022-2461- Author Web Link
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- Citations: 22
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Journal articleSarkar S, Caddick MX, Bignell E, et al., 2004,
Erratum: Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acidic pH (Biochemical Society Transactions (1996) 24, Part 2 (360-363))
, Biochemical Society Transactions, Vol: 32, ISSN: 0300-5127
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