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  • Journal article
    Moffatt MF, Sharp PA, Faux JA, Young RP, Cookson WO, Hopkin JMet al., 1992,

    Factors confounding genetic linkage between atopy and chromosome 11q.

    , Clin Exp Allergy, Vol: 22, Pages: 1046-1051, ISSN: 0954-7894

    The results of testing for linkage between atopy and the chromosome 11 marker D11S97 is shown for all the 723 subjects genotyped by us up to January 1992. Lod score estimations were confounded by the high population prevalence of atopy, maternal inheritance of atopy at the 11q locus, genetic heterogeneity, and excess of atopy in families not ascertained through a single proband. Affected sib-pair analysis shows evidence for linkage which is not dependent on the definition of atopy or model specification. We suggest that presentation of sib-pair data will be suitable for meta-analysis of the different studies of genetic linkage and atopy.

  • Journal article
    HUNTER GD, BAILEY CR, ARST HN, 1992,

    EXPRESSION OF A BACTERIAL ASPARTASE GENE IN ASPERGILLUS-NIDULANS - AN EFFICIENT SYSTEM FOR SELECTING MULTICOPY TRANSFORMANTS

    , CURRENT GENETICS, Vol: 22, Pages: 377-383, ISSN: 0172-8083
  • Journal article
    Cook JT, Hattersley AT, Christopher P, Bown E, Barrow B, Patel P, Shaw JA, Cookson WO, Permutt MA, Turner RCet al., 1992,

    Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.

    , Diabetes, Vol: 41, Pages: 1496-1500, ISSN: 0012-1797

    NIDDM has a strong genetic component, as evidenced by the high level of concordance between identical twins. The nature of the genetic predisposition has remained largely unknown. Recently, the glucokinase gene locus on chromosome 7p has been shown to be linked to a subtype of NIDDM known as MODY in French and British pedigrees, and glucokinase mutations have been identified. To study the relationship between the glucokinase gene and NIDDM, we performed a linkage analysis in 12 Caucasian pedigrees ascertained through a proband with classical NIDDM. The LINKAGE program was used under four models, including autosomal dominant and recessive, with individuals with glucose intolerance counted as either affected or of unknown status. Linkage was significantly rejected with the dominant models (LOD scores -4.65, -4.25), and was unlikely with the recessive model when glucose intolerance was considered as affected (LOD score -1.38). These findings suggest that mutations in or near the glucokinase gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but do not exclude a role for this locus with a polygenic model, or a major role in some pedigrees.

  • Journal article
    COOKSON W, YOUNG RP, SANDFORD AJ, MOFFATT MF, SHIRAKAWA T, SHARP PA, FAUX JA, JULIER C, LESOUEF PN, NAKAMURA Y, LATHROP GM, HOPKIN JMet al., 1992,

    MATERNAL INHERITANCE OF ATOPIC IGE RESPONSIVENESS ON CHROMOSOME-11Q

    , LANCET, Vol: 340, Pages: 381-384, ISSN: 0140-6736
  • Journal article
    Musk AW, Ryan G, James A, Cookson Wet al., 1992,

    Factors in job decisions.

    , J Occup Med, Vol: 34, Pages: 593-594, ISSN: 0096-1736
  • Journal article
    YOUNG RP, SHARP PA, LYNCH JR, FAUX JA, LATHROP GM, COOKSON W, HOPKIN JMet al., 1992,

    CONFIRMATION OF GENETIC-LINKAGE BETWEEN ATOPIC IGE RESPONSES AND CHROMOSOME-11Q13

    , JOURNAL OF MEDICAL GENETICS, Vol: 29, Pages: 236-238, ISSN: 0022-2593
  • Journal article
    DANIELS RJ, THOMAS NH, MACKINNON RN, LEHNER T, OTT J, FLINT TJ, DUBOWITZ V, IGNATIUS J, DONNER M, ZERRES K, RIETSCHEL M, COOKSON WOC, BRZUSTOWICZ LM, GILLIAM TC, DAVIES KEet al., 1992,

    LINKAGE ANALYSIS OF SPINAL MUSCULAR-ATROPHY

    , GENOMICS, Vol: 12, Pages: 335-339, ISSN: 0888-7543
  • Journal article
    ARST HN, 1992,

    GENE-REGULATION IN MICROBIAL EUKARYOTES IN THE EARLY 1990S

    , WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, Vol: 8, Pages: 22-23, ISSN: 0959-3993
  • Journal article
    Cookson WOCM, 1992,

    Erratum: Maternal inheritance of atopic IgE responsiveness on chromosomes (The Lancet (Aug 15) p 381)

    , Lancet, Vol: 340, ISSN: 0140-6736
  • Journal article
    SPANU P, REINHARDT D, BOLLER T, 1991,

    ANALYSIS AND CLONING OF THE ETHYLENE-FORMING ENZYME FROM TOMATO BY FUNCTIONAL EXPRESSION OF ITS MESSENGER-RNA IN XENOPUS-LAEVIS OOCYTES

    , EMBO JOURNAL, Vol: 10, Pages: 2007-2013, ISSN: 0261-4189

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