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Journal articleZhang Y, Leaves NI, Anderson GG, et al., 2003,
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma
, Nature Genetics, Vol: 34, Pages: 181-186, ISSN: 1061-4036Atopic or immunoglobulin E (IgE)-mediated diseases include the common disorders of asthma, atopic dermatitis and allergic rhinitis1. Chromosome 13q14 shows consistent linkage to atopy and the total serum IgE concentration2,3,4,5,6. We previously identified association between total serum IgE levels and a novel 13q14 microsatellite (USAT24G1; ref. 7) and have now localized the underlying quantitative-trait locus (QTL) in a comprehensive single-nucleotide polymorphism (SNP) map. We found replicated association to IgE levels that was attributed to several alleles in a single gene, PHF11. We also found association with these variants to severe clinical asthma. The gene product (PHF11) contains two PHD zinc fingers and probably regulates transcription. Distinctive splice variants were expressed in immune tissues and cells.
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Journal articleTurner MW, Johnson M, Booth C, et al., 2003,
Assays for human mannose-binding lectin
, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 276, Pages: 147-149, ISSN: 0022-1759- Author Web Link
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- Citations: 7
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Journal articleDonnadieu E, Jouvin MH, Rana S, et al., 2003,
Competing functions encoded in the allergy-associated <i>Fc</i>ε<i>RI</i>β gene
, IMMUNITY, Vol: 18, Pages: 665-674, ISSN: 1074-7613- Author Web Link
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- Citations: 56
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Journal articleBidartondo MI, Bruns TD, Weiss M, et al., 2003,
Specialized cheating of the ectomycorrhizal symbiosis by an epiparasitic liverwort.
, Proceedings of the Royal Society B, Vol: 270, Pages: 835-842, ISSN: 0962-8452Many non-photosynthetic vascular plants in 10 diverse families obtain all of their carbon from fungi, but in most cases the fungi and the ultimate sources of carbon are unknown. In a few cases, such plants have been shown to be epiparasitic because they obtain carbon from neighbouring green plants through shared mycorrhizal fungi. In all such cases, the epiparasitic plants have been found to specialize upon narrow lineages of ecto- or arbuscular mycorrhizal fungi. Here we show that a non-vascular plant, the non-photosynthetic liverwort Cryptothallus mirabilis, is epiparasitic and is specialized on Tulasnella species that form ectomycorrhizae with surrounding trees at four locations in England, France and Portugal. By using microcosm experiments we show that the interaction with Tulasnella is necessary for growth of Cryptothallus, and by using labelling experiments we show that (14)CO(2) provided to birch seedlings is transferred to Cryptothallus by Tulasnella. This is one of the first documented cases of epiparasitism by a non-vascular plant and of ectomycorrhizal formation by Tulasnella. These results broaden the emerging association between epiparasitism and mycorrhizal specialization into a new class of plants and a new order of fungi.
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Journal articleFlipphi M, van de Vondervoort PJI, Ruijter GJG, et al., 2003,
Onset of carbon catabolite repression in <i>Aspergillus nidulans</i> -: Parallel involvement of hexokinase and glucokinase in sugar signaling
, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 11849-11857, ISSN: 0021-9258- Author Web Link
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- Citations: 72
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Journal articleWells AU, Desai SR, Rubens MB, et al., 2003,
Idiopathic pulmonary fibrosis - A composite physiologic index derived from disease extent observed by computed tomography
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 167, Pages: 962-969, ISSN: 1073-449X- Author Web Link
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- Citations: 489
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Journal articlePantelidis P, Lagan AL, Davies JC, et al., 2003,
A single round PCR method for genotyping human surfactant protein (SP)-A1, SP-A2 and SP-D gene alleles
, TISSUE ANTIGENS, Vol: 61, Pages: 317-321, ISSN: 0001-2815- Author Web Link
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- Citations: 16
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Journal articleArst HN, Peñalva MA, 2003,
pH regulation in <i>Aspergillus</i> and parallels with higher eukaryotic regulatory systems
, TRENDS IN GENETICS, Vol: 19, Pages: 224-231, ISSN: 0168-9525- Author Web Link
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- Citations: 102
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Journal articleCookson W, 2003,
A new gene for asthma: would you ADAM and Eve it?
, TRENDS IN GENETICS, Vol: 19, Pages: 169-172, ISSN: 0168-9525- Author Web Link
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- Citations: 20
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Journal articleDavies G, McShane D, Davies JC, et al., 2003,
Multiresistant <i>Pseudomonas aeruginosa</i> in a pediatric cystic fibrosis center:: Natural history and implications for segregation
, PEDIATRIC PULMONOLOGY, Vol: 35, Pages: 253-256, ISSN: 8755-6863- Author Web Link
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- Citations: 18
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