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• Conference paper
  Cookson WO, De Klerk NH, Ryan GR, James AL, Musk AWet al., 1991,

  Relative risks of bronchial hyper-responsiveness associated with skin-prick test responses to common antigens in young adults.

  , Pages: 473-479, ISSN: 0954-7894

  We studied 143 young subjects by skin-prick testing to common allergens and by the measurement of non-specific bronchial responsiveness (NSBR). A logistic regression model showed a prevalence odds ratio (POR) for bronchial hyper-responsiveness (PD20 less than 10 mumol methacholine) in house dust positive subjects of 4.10 (95% CI 1.77-9.51, P less than 0.001), and in mould positive subjects 5.72 (95% CI 2.06-15.9, P less than 0.001): the PORs for epithelia (2.05, P = 0.12) and grasses (1.78, P = 0.19) were not significant. If bronchial reactivity was assessed as measurable (PD20 less than 102 mumol methacholine) or not, the POR for house-dust-positive subjects was 4.83 (95% CI 2.23-10.5, P less than 0.001), for moulds was 10.5 (95% CI 2.33-47.5, P less than 0.001), for epithelia was 4.79 (95% CI 1.91-12.0, P less than 0.001), and for grasses was 2.21 (95% CI 1.11-4.4, P = 0.022). The results show the risk of bronchial hyper-responsiveness is greater in subjects sensitive to house dust and mould than in those reactive to grasses, and suggests that the presence or absence of increased NSBR in atopic individuals may depend on the antigens to which they become sensitized.

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• Journal article
  CONNELLY JC, ARST HN, 1991,

  IDENTIFICATION OF A TELOMERIC FRAGMENT FROM THE RIGHT ARM OF CHROMOSOME-III OF ASPERGILLUS-NIDULANS

  , FEMS MICROBIOLOGY LETTERS, Vol: 80, Pages: 295-298, ISSN: 0378-1097
  • Author Web Link
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  • Citations: 10
• Journal article
  Connelly JC, Arst HN, 1991,

  Identification of a telomeric fragment from the right arm of chromosome III of Aspergillus nidulans.

  , FEMS Microbiol Lett, Vol: 64, Pages: 295-297, ISSN: 0378-1097

  A minimum of 11 bands hybridising to an oligonucleotide complementary to the putative telomeric repeat sequence (TTAGGG)n was visible in a Southern blot of EcoRI-digested Aspergillus nidulans genomic DNA. All 11 were sensitive to BAL 31 exonuclease digestion, consistent with telomeric locations. Blots of DNA from aneuploid strains deleted for a dispensable, extreme distal region on the right arm of chromosome III lack a 1.3-kb EcoRI band, indicating that this fragment is located at or near the chromosome III right arm telomere.

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• Journal article
  SHAH AJ, TILBURN J, ADLARD MW, ARST HNet al., 1991,

  PH REGULATION OF PENICILLIN PRODUCTION IN ASPERGILLUS-NIDULANS

  , FEMS MICROBIOLOGY LETTERS, Vol: 77, Pages: 209-212, ISSN: 0378-1097
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  • Citations: 55
• Journal article
  Shah AJ, Tilburn J, Adlard MW, Arst HNet al., 1991,

  pH regulation of penicillin production in Aspergillus nidulans.

  , FEMS Microbiol Lett, Vol: 61, Pages: 209-212, ISSN: 0378-1097

  As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pacC which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the palA, palB, palC, palE or palF genes which mimic the effects of growth at acid pH.

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• Journal article
  Hopkin JM, Cookson WO, Young RP, 1991,

  Asthma, atopy, and genetic linkage.

  , Ann N Y Acad Sci, Vol: 629, Pages: 26-30, ISSN: 0077-8923
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• Journal article
  CADDICK MX, ARST HN, 1990,

  NITROGEN REGULATION IN ASPERGILLUS - ARE 2 FINGERS BETTER THAN ONE

  , GENE, Vol: 95, Pages: 123-127, ISSN: 0378-1119
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  • Citations: 12
• Journal article
  Gardiner M, Sandford A, Deadman M, Poulton J, Cookson W, Reeders S, Jokiaho I, Peltonen L, Eiberg H, Julier Cet al., 1990,

  Batten disease (Spielmeyer-Vogt disease, juvenile onset neuronal ceroid-lipofuscinosis) gene (CLN3) maps to human chromosome 16.

  , Genomics, Vol: 8, Pages: 387-390, ISSN: 0888-7543

  The ceroid-lipofuscinoses are a group of inherited neurodegenerative disorders characterized by the accumulation of autofluorescent lipopigment in neurons and other cell types. The underlying biochemical defect is unknown. Batten disease (Spielmeyer-Vogt disease, juvenile onset neuronal ceroid-lipofuscinosis) displays autosomal recessive inheritance. Genetic linkage studies were undertaken to determine the chromosomal location of the Batten disease mutation (CLN3). Following identification of linkage to the haptoglobin locus, linkage analysis has been carried out in 42 families by using DNA markers for loci on the long arm of human chromosome 16. The maximal lod score between Batten disease and the locus D16S148 calculated for combined sexes is 6.05 at a recombination fraction theta = 0.00. Multilocus analysis using five loci indicated the most likely order to be HP-D16S151-D16S150-CLN3-D16S148-D16S147. The maximal location score for CLN3 was 48 (equivalent to a lod score of 10.4) in that interval within this fixed marker map.

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• Journal article
  ARST HN, HONDMANN DHA, VISSER J, 1990,

  A TRANSLOCATION ACTIVATING THE CRYPTIC NITROGEN REGULATION GENE AREB INACTIVATES A PREVIOUSLY UNIDENTIFIED GENE INVOLVED IN GLYCEROL UTILIZATION IN ASPERGILLUS-NIDULANS

  , MOLECULAR & GENERAL GENETICS, Vol: 223, Pages: 134-137, ISSN: 0026-8925
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  • Citations: 12
• Journal article
  SPANU P, FELIX G, BOLLER T, 1990,

  INACTIVATION OF STRESS-INDUCED 1-AMINOCYCLOPROPANE CARBOXYLATE SYNTHASE INVIVO DIFFERS FROM SUBSTRATE-DEPENDENT INACTIVATION INVITRO

  , PLANT PHYSIOLOGY, Vol: 93, Pages: 1482-1485, ISSN: 0032-0889
  • Author Web Link
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  • Citations: 28

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