Publications

Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Yankovskaya V, Horsefield R, Törnroth S, Luna-Chavez C, Miyoshi H, Léger C, Byrne B, Cecchini G, Iwata Set al., 2003,

    Architecture of succinate dehydrogenase and reactive oxygen species generation

    , SCIENCE, Vol: 299, Pages: 700-704, ISSN: 0036-8075
  • Conference paper
    Kagoshima M, Ito K, Cosio B, Adcock IMet al., 2003,

    Glucocorticoid suppression of nuclear factor-κB: A role for histone modifications

    , Pages: 60-65, ISSN: 0300-5127

    Corticosteroids are by far the most effective treatment for chronic inflammatory diseases such as asthma. Inflammation in asthma is characterized by the increased expression of multiple inflammatory genes, including those that encode cytokines, chemokines, adhesion molecules, and inflammatory enzymes and receptors. Increased expression of inflammatory genes is regulated by pro-inflammatory transcription factors, such as nuclear factor κB (NF-κB). These bind to, and activate, co-activator molecules that then acetylate core histones resulting in elevated gene transcription. Corticosteroids reverse histone acetylation at the site of inflammatory gene transcription, either by direct binding of the activated glucocorticoid receptor to NF-κB-associated co-activators or by recruitment of histone deacetylases to the activated transcription complex. Understanding how corticosteroids work in asthma may help in designing novel corticosteroids with fewer systemic effects, as well as novel anti-inflammatory approaches.
  • Journal article
    McShane D, Davies JC, Davies MG, Bush A, Geddes DM, Alton EWFWet al., 2003,

    Airway surface pH in subjects with cystic fibrosis

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 21, Pages: 37-42, ISSN: 0903-1936
  • Book chapter
    Bush A, Davies JC, 2003,

    Cystic Fibrosis in Childhood

    , Respiratory Medicene 3rd Edition, Editors: Gibson, Geddes, Costabel, Sterk, Corrin, Gibson, Geddes, Costabel, Sterk, Corrin, Publisher: Saunders, Pages: 1477-1494, ISBN: 9780702026133
  • Book chapter
    Byrne B, Iwata S, 2003,

    Generating antibody fragments for structural studies: a guide

    , Publisher: International University Line, Pages: 89-100
  • Book chapter
    Abramson J, Byrne B, Iwata S, 2003,

    Crystallization of cytochrome bo3 ubiquinol oxidase from E. coli

    , Publisher: International University Line, Pages: 227-238
  • Journal article
    Safinia L, Blaker JJ, Lim J, Maquet V, Boccaccini AR, Bismarck A, Mantalaris Aet al., 2003,

    In vitro evaluation and surface characterisation of bioresorbable polylactide foams, surface coated with fibronectin and collagen (Poster)

    , European Cells and Materials Journal, Vol: 5, Pages: 84-85, ISSN: 1473-2262
  • Journal article
    Aranberri I, Bismarck A, 2003,

    Etekin handiko materialak biharko gizartean

    , Elhuyar, Vol: 187, Pages: 20-23, ISSN: 0213-3687
  • Journal article
    Iwata M, Abramson J, Byrne B, Iwata Set al., 2003,

    Structure and function of quinone binding membrane proteins

    , MEMBRANE PROTEINS, Vol: 63, Pages: 151-176, ISSN: 0065-3233
  • Book chapter
    Davies, Geddes, Alton, 2003,

    Pulmonary Gene Therapy

    , Pharmaceutical Gene Delivery Systems, Editors: Rolland, Sullivan, New York, Publisher: Marcel Dekker Inc., Pages: 363-396, ISBN: 9780824742355

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1255&limit=10&resgrpMemberPubs=true&resgrpMemberPubs=true&page=333&respub-action=search.html Current Millis: 1713994002750 Current Time: Wed Apr 24 22:26:42 BST 2024