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  • Journal article
    Cookson WO, Hopkin JM, 1988,

    Dominant inheritance of atopic immunoglobulin-E responsiveness.

    , Lancet, Vol: 1, Pages: 86-88, ISSN: 0140-6736

    The familial occurrence of atopy, defined by skin prick test responses and serum immunoglobulin-E (IgE) titres to common inhaled allergens, was studied in 239 members of 40 nuclear and 3 extended families. 90% of the atopic children in the nuclear families had at least one demonstrably atopic parent. In each extended family, atopy was vertically transmitted, and 31 of 47 (66%) offspring of marriages between atopic and unaffected parents were atopic. Of the designated atopic subjects, 83% admitted to symptoms suggesting atopic disease but only 30% regarded themselves as having any such disorder. It is suggested that atopy, the propensity to produce IgE in response to common, usually inhaled, allergens, is inherited as an autosomal dominant character but that its clinical expression depends on interaction with other factors.

  • Journal article
    Higgins RM, Cookson WO, Lane DJ, John SM, McCarthy GL, McCarthy STet al., 1987,

    Cardiac arrhythmias caused by nebulised beta-agonist therapy.

    , Lancet, Vol: 2, Pages: 863-864, ISSN: 0140-6736
  • Journal article
    Cookson WO, 1987,

    Bronchodilator action of the anti-histaminic terfenadine.

    , Br J Clin Pharmacol, Vol: 24, Pages: 120-121, ISSN: 0306-5251
  • Journal article
    ARST HN, 1987,

    FIXING ON AN ENIGMA

    , MICROBIOLOGICAL SCIENCES, Vol: 4, Pages: 58-58, ISSN: 0265-1351
  • Journal article
    Arst HN, 1987,

    Fixing on an enigma.

    , Microbiol Sci, Vol: 4, ISSN: 0265-1351
  • Journal article
    Kingsbury AC, Frost F, Cookson WO, 1987,

    Dysgerminoma, gonadoblastoma, and testicular germ cell neoplasia in phenotypically female and male siblings with 46 XY genotype.

    , Cancer, Vol: 59, Pages: 288-291, ISSN: 0008-543X

    46 XY gonadal dysgenesis is a syndrome characterized by a female phenotype with streak gonads and complicated by the frequent occurrence of germ cell tumors. The syndrome and the risk of malignant disease occur in female siblings sharing the XY genotype, and screening of female siblings and prophylactic gonadectomy in those affected is generally recommended. A family of four siblings is described in which two phenotypically female XY children and one male each have developed germ cell tumors, demonstrating that brothers of affected sisters may also be at risk.

  • Journal article
    Higgins RM, Cookson WOCM, Lane DJ, John SM, McCarthy GL, McCarthy STet al., 1987,

    Cardiac arrhythmias caused by nebulised beta-agonist therapy

    , Lancet, Vol: 2, ISSN: 0140-6736
  • Journal article
    Higgins RM, Cookson WO, Chadwick GA, 1987,

    Changes in blood gas levels after nebuhaler and nebulizer administration of terbutaline in severe chronic airway obstruction.

    , Bull Eur Physiopathol Respir, Vol: 23, Pages: 261-264, ISSN: 0395-3890

    It has been suggested that patients with severe chronic airway obstruction might suffer dangerous hypoxia after administration of a beta-agonist through an air driven nebulizer. Twenty patients with severe chronic airway obstruction (12 male, mean age 71.1 (SEM 1.5) yr) were monitored with a Biox oximeter and Hewlett-Packard capnometer before and after 4 mg terbutaline was delivered through an air driven nebulizer or Nebuhaler. The eight patients with chronic hypoxia (mean PaO2 6.76 kPa, PaCO2 7.47 kPa. FEV1 0.53 l) experienced a 4.7% increase in oxygen saturation (SaO2) and 2.9% fall in transcutaneous carbon dioxide tension (PtcCO2) (p less than 0.05) during all treatments, followed by a return to initial levels. These changes were attributable to increased ventilation whilst breathing through a mouthpiece. A similar trend was seen in the SaO2 of the twelve normoxic patients (mean PaO2 9.32 kPa, PaCO2 5.34 kPa, FEV1 0.8 l), but there was a sustained fall in PtcCO2 of 3.7% (p less than 0.001) after administration of terbutaline. Inhaled terbutaline in the dosage given did not cause hypoxia in patients with severe chronic airflow obstruction, but nebulizer and Nebuhaler use was associated with a rise in SaO2 related to increased ventilation whilst breathing through a mouthpiece.

  • Journal article
    Shale DJ, Wiseman MS, Cookson WO, 1986,

    Effect of monocrotaline ingestion on the distribution of protein and angiotensin converting enzyme activity in the rat lung.

    , Thorax, Vol: 41, Pages: 914-918, ISSN: 0040-6376

    The alveolar accumulation of protein and angiotensin converting enzyme activity was compared with the development of right ventricular hypertrophy in male rats after different periods of monocrotaline exposure. Total doses of monocrotaline were varied by dividing the animals into three groups in which ingestion was limited to three, seven, and 15 days. These groups were studied 21 days after the start of monocrotaline exposure and compared with a group treated continuously for 28 days. The total lung weight increased after three or more days of treatment, while after seven days there was significant alveolar accumulation of protein, which was paralleled by an increase in angiotensin converting enzyme activity in alveolar lavage fluid. Identical changes also occurred after 15 and 28 days of exposure to monocrotaline. Lung angiotensin converting enzyme activity was decreased after three days' ingestion of monocrotaline and did not alter further with longer periods of exposure. None of these effects of monocrotaline in the three and seven day treatment groups was associated with right ventricular hypertrophy, which occurred only in animals treated for 15 or more days. The effects of monocrotaline ingestion on the lung were dose related and had no causal relationship to the development of right ventricular hypertrophy.

  • Journal article
    James AL, Cookson WO, Buters G, Lewis S, Ryan G, Hockey R, Musk AWet al., 1986,

    Symptoms and longitudinal changes in lung function in young seasonal grain handlers.

    , Br J Ind Med, Vol: 43, Pages: 587-591, ISSN: 0007-1072

    A total of 119 seasonal grain handlers (mean age 23) were assessed before and towards the end (mean work period 18 days) of the 1983 Western Australian grain harvest to determine if respiratory symptoms that occur with exposure to grain dust are associated with changes in ventilatory capacity or non-specific bronchial reactivity to methacholine. Eighteen per cent of subjects had wheeze, breathlessness, or chest tightness and 18% had cough or sputum production at work. Subjects complaining of wheeze, chest tightness, or breathlessness at work had a significantly greater decline in FEV1 than subjects who did not experience these symptoms (p less than 0.05). Symptoms were not associated with changes in bronchial reactivity. In young grain handlers who develop respiratory symptoms on short term exposure to grain dust changes in FEV1 but not in non-specific bronchial reactivity have been demonstrated.

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