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Journal articleTomita K, Caramori G, Lim S, et al., 2002,
Increased p21<SUP>CIP1/WAF1</SUP> and B cell lymphoma leukemia-x<sub>L</sub> expression and reduced apoptosis in alveolar macrophages from smokers
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 166, Pages: 724-731, ISSN: 1073-449X- Author Web Link
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- Citations: 100
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Journal articleHarris RS, 2002,
Acute respiratory distress syndrome: imaging of the injured lung.
, Clin Radiol, Vol: 57, ISSN: 0009-9260 -
Journal articleWhiteford JR, Spanu PD, 2002,
Hydrophobins and the interactions between fungi and plants
, MOLECULAR PLANT PATHOLOGY, Vol: 3, Pages: 391-400, ISSN: 1464-6722- Author Web Link
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- Citations: 108
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Journal articlePeñalva MA, Arst HN, 2002,
Regulation of gene expression by ambient pH in filamentous fungi and yeasts.
, Microbiol Mol Biol Rev, Vol: 66, Pages: 426-446, ISSN: 1092-2172Life, as we know it, is water based. Exposure to hydroxonium and hydroxide ions is constant and ubiquitous, and the evolutionary pressure to respond appropriately to these ions is likely to be intense. Fungi respond to their environments by tailoring their output of activities destined for the cell surface or beyond to the ambient pH. We are beginning to glimpse how they sense ambient pH and transmit this information to the transcription factor, whose roles ensure that a suitable collection of gene products will be made. Although relatively little is known about pH signal transduction itself, its consequences for the cognate transcription factor are much clearer. Intriguingly, homologues of components of this system mediating the regulation of fungal gene expression by ambient pH are to be found in the animal kingdom. The potential applied importance of this regulatory system lies in its key role in fungal pathogenicity of animals and plants and in its control of fungal production of toxins, antibiotics, and secreted enzymes.
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Journal articleSheehan RE, Wells AU, Copley SJ, et al., 2002,
A comparison of serial computed tomography and functional change in bronchiectasis
, EUROPEAN RESPIRATORY JOURNAL, Vol: 20, Pages: 581-587, ISSN: 0903-1936- Author Web Link
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- Citations: 99
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Journal articleBruns T, Tan J, Bidartondo M, et al., 2002,
Survival of Suillus pungens and Amanita francheti ectomycorrhizal genets was rare or absent after a stand-replacing wildfire
, New Phytologist, Vol: 155, Pages: 517-523, ISSN: 0028-646XWe looked for evidence of mycelial survival by Suillus pungens and Amanita francheti following a stand-replacing wildfire. These species were selected because we had previously mapped and genotyped their fruiting bodies in the pre-fire forest.Mycelial survival was investigated in two ways. First, we sampled seedlings in areas where these species had fruited abundantly before the fire, and second, we collected and genotyped mushrooms of S. pungens.Neither species was detected on seedlings within the areas sampled, and A. francheti was not detected in any above- or below-ground samples after the fire. Genetic evidence from S. pungens revealed that post-fire genets were small and numerous, and none were found to be identical to the genets sampled prior to the fire.From these results we conclude that A. francheti was not a common survivor or an early colonist of the post-fire forest, and that spores are the primary means by which S. pungens recolonized. If mycelial survival occurred in either species, it must have been relatively rare.
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Journal articlePeñalva MA, Arst HN, 2002,
Regulation of gene expression by ambient pH in filamentous fungi and yeasts
, MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Vol: 66, Pages: 426-+, ISSN: 1092-2172- Author Web Link
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- Citations: 239
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Journal articleIto K, Caramori G, Lim S, et al., 2002,
Expression and activity of histone deacetylases in human asthmatic airways
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 166, Pages: 392-396, ISSN: 1073-449X- Author Web Link
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- Citations: 244
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Journal articleWaring MJ, Ben-Hadda T, Kotchevar AT, et al., 2002,
2,3-bifunctionalized quinoxalines: Synthesis, DNA interactions and evaluation of anticancer, anti-tuberculosis and antifungal activity
, MOLECULES, Vol: 7, Pages: 641-656, ISSN: 1420-3049- Author Web Link
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- Citations: 86
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Journal articleCookson WOCM, Harper JI, Moffatt MF, 2002,
Genetics of atopic dermatitis
, Immunology and Allergy Clinics of North America, Vol: 22, Pages: 199-209, ISSN: 0889-8561Even though the comprehension of the genetics of AD is at an early stage, further studies offer the promise of a greater understanding. The preliminary findings emphasize the importance of the skin as a barrier and suggest that the atopy that accompanies AD might be as much a secondary phenomenon as a primary phenomenon. The barrier function of the skin is not merely passive, and the skin maintains a specific immunologic environment, referred to as the skin immune system [76]. The skin immune system is characterized by the presence of a dense network of dendritic, antigen-presenting cells (Langerhan's cells) in the epidermis and perivascular localization of T lymphocytes that are activated even in the skin of normal individuals [76,77]. The polymorphic nature of genes and gene families expressed in the skin suggest a polyvalent response to a number of different stimuli, including infections. It is possible that some of these proteins might have unrecognized anti-infective properties. The recognition of the importance of genetic effects to AD, together with advances in the understanding and technology of complex genetics, will result in a new understanding of AD.
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