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  • Journal article
    Cookson WO, Musk AW, Ryan G, 1986,

    Associations between asthma history, atopy, and non-specific bronchial responsiveness in young adults.

    , Clin Allergy, Vol: 16, Pages: 425-432, ISSN: 0009-9090

    In 105 subjects taken from a student population and aged between 15 and 30 there was a strong positive association between the presence of the atopic state, defined by skin tests, and a high level of non-specific bronchial responsiveness to methacholine (chi 2 = 10.5, d.f. = 2, P = 0.01). Regression analysis showed a history of asthma, and the symptom of wheeze, to be predominantly predicted by the degree of bronchial responsiveness (R2 = 31%), with only a minor independent contribution from the degree of atopy (R2 a further 5%). The genetic or other reasons for the association between bronchial responsiveness and atopy may have importance in understanding the aetiology of allergic asthma.

  • Journal article
    ARST HN, 1986,

    COMING UP FOR AIR - A REQUIREMENT FOR SUPEROXIDE-DISMUTASE

    , MICROBIOLOGICAL SCIENCES, Vol: 3, Pages: 247-248, ISSN: 0265-1351
  • Journal article
    Arst HN, 1986,

    Exploiting classical genetics to clone a eukaryotic regulatory gene.

    , Microbiol Sci, Vol: 3, ISSN: 0265-1351
  • Journal article
    Cookson WO, De Klerk NH, Musk AW, Armstrong BK, Glancy JJ, Hobbs MSet al., 1986,

    Prevalence of radiographic asbestosis in crocidolite miners and millers at Wittenoom, Western Australia.

    , Br J Ind Med, Vol: 43, Pages: 450-457, ISSN: 0007-1072

    An estimate has been made of the prevalence of unrecognised pneumoconiosis in former crocidolite workers from Wittenoom, Western Australia. All plain chest radiographs relating to a one in six random sample (1025 men) of all former Wittenoom workers who had never entered a compensation claim to the Pneumoconiosis Medical Board of Western Australia were sought from Perth teaching hospitals and from the Perth Chest Clinic where compulsory examination of all workers in the mining industry takes place. Radiographs were recovered for 83% of the men and read independently by two observers. By means of logistic regression analysis a current prevalence of parenchymal abnormality (defined as a radiographic profusion of small opacities of category 1/0 or greater on the ILO classification) of nearly 20% was calculated after adjustment for age, time since first exposure, and cumulative exposure level. One hundred men randomly selected from those known to be alive in the sample were invited to attend for a new radiographic examination. Seventy four men attended and the predicted prevalence was confirmed. It is estimated from these data that there were between 450 and 900 former Wittenoom workers in Australia at the end of 1980 who had radiographic abnormality consistent with pneumoconiosis but had not claimed compensation or had asbestosis diagnosed. The data are consistent with there being no threshold dose of crocidolite exposure for the development of radiographic abnormality in this group.

  • Journal article
    ARST HN, 1986,

    PH AND THE CONTROL OF GENE-EXPRESSION

    , MICROBIOLOGICAL SCIENCES, Vol: 3, Pages: 189-190, ISSN: 0265-1351
  • Journal article
    Cookson WO, Ryan G, MacDonald S, Musk AWet al., 1986,

    Atopy, non-allergic bronchial reactivity, and past history as determinants of work related symptoms in seasonal grain handlers.

    , Br J Ind Med, Vol: 43, Pages: 396-400, ISSN: 0007-1072

    One hundred and five young subjects with little or no previous exposure to grain dust were studied before and after a seven week period of grain handling work to determine if there was an association between symptoms experienced at work and pre-employment respiratory symptoms, allergy skin test responses, and non-allergic bronchial reactivity. The incidence of work related symptoms was cough 18%, wheeze 13%, and dyspnoea 14%. The results showed that pre-employment history of respiratory symptoms, positive allergy skin test responses, and a high level of non-allergic bronchial reactivity were significantly associated with these symptoms. These measurements may be useful to predict symptoms associated with exposure to grain dust in new employees and the results suggest that these work related symptoms may be due to allergen induced asthma.

  • Journal article
    Cookson W, De Klerk N, Musk AW, Glancy JJ, Armstrong B, Hobbs Met al., 1986,

    The natural history of asbestosis in former crocidolite workers of Wittenoom Gorge.

    , Am Rev Respir Dis, Vol: 133, Pages: 994-998, ISSN: 0003-0805

    The course of pulmonary asbestosis and its determinants have been examined in 280 applicants for compensation among former workers of the crocidolite mine and mill at Wittenoom Gorge, Western Australia. Serial chest radiographs accrued over more than 3 decades were graded for parenchymal disease separately by two observers according to the 1980 ILO Classification of Radiographs for Pneumoconioses and without knowledge of exposure histories or compensation details. In 136 subjects whose median duration of exposure was 37 months, radiographic asbestosis appeared between 1 and 34 yr after initial exposure and then progressed continuously. Total exposure to asbestos and time from first exposure to the appearance of definite radiographic asbestosis were significant determinants of the rate of progression of profusion of radiographic abnormality. Asbestosis should be considered to be an active disease even 3 decades after exposure has ended.

  • Journal article
    CADDICK MX, ARST HN, TAYLOR LH, JOHNSON RI, BROWNLEE AGet al., 1986,

    CLONING OF THE REGULATORY GENE AREA MEDIATING NITROGEN METABOLITE REPRESSION IN ASPERGILLUS-NIDULANS

    , EMBO JOURNAL, Vol: 5, Pages: 1087-1090, ISSN: 0261-4189
  • Journal article
    CADDICK MX, BROWNLEE AG, ARST HN, 1986,

    PHOSPHATASE REGULATION IN ASPERGILLUS-NIDULANS - RESPONSES TO NUTRITIONAL STARVATION

    , GENETICAL RESEARCH, Vol: 47, Pages: 93-102, ISSN: 0016-6723
  • Journal article
    ARST HN, 1986,

    FOR THE WANT OF ZWISCHENFERMENT

    , MICROBIOLOGICAL SCIENCES, Vol: 3, Pages: 114-115, ISSN: 0265-1351

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