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  • Conference paper
    Eichhorn SJ, Quero F, Lee K-Y, Mantalaris A, Bismarck Aet al., 2011,

    Mechanics of bacterial cellulose composite interfaces

    , 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
  • Conference paper
    Wong LC, Ikem VO, Menner A, Bismarck Aet al., 2011,

    Hierarchically arranged pores in macroporous polymers synthesised using high internal phase emulsions stabilized by functionalized titania nanoparticles

    , 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
  • Conference paper
    Lee K-Y, Bharadia P, Blaker JJ, Bismarck Aet al., 2011,

    Renewable hierarchical fibre reinforced bacterial cellulose nanocomposites with improved properties

    , 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
  • Journal article
    Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJet al., 2011,

    Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.

    , Biochem Biophys Res Commun, Vol: 406, Pages: 292-298

    Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence against oxidative stress by inducing the expression of multiple anti-oxidant genes. However, where high levels of oxidative stress are observed, such as chronic obstructive pulmonary disease (COPD), Nrf2 activity is reduced, although the molecular mechanism for this defect is uncertain. Here, we show that down-regulation of histone deacetylase (HDAC) 2 causes Nrf2 instability, resulting in reduced anti-oxidant gene expression and increase sensitivity to oxidative stress. Although Nrf2 protein was clearly stabilized after hydrogen peroxide (H(2)O(2)) stimulation in a bronchial epithelial cell line (BEAS2B), Nrf2 stability was decreased and Nrf2 acetylation increased in the presence of an HDAC inhibitor, trichostatin A (TSA). TSA also reduced Nrf2-regulated heme-oxygenase-1 (HO-1) expression in these cells, and this was confirmed in acute cigarette-smoke exposed mice in vivo. HDAC2 knock-down by RNA interference resulted in reduced H(2)O(2)-induced Nrf2 protein stability and activity in BEAS2B cells, whereas HDAC1 knockdown had no effect. Furthermore, monocyte-derived macrophages obtained from healthy volunteers (non-smokers and smokers) and COPD patients showed a significant correlation between HDAC2 expression and Nrf2 expression (r=0.92, p<0.0001). Thus, reduced HDAC2 activity in COPD may account for increased Nrf2 acetylation, reduced Nrf2 stability and impaired anti oxidant defences.
  • Journal article
    Bidartondo MI, Read DJ, Trappe JM, Merckx V, Ligrone R, Duckett JGet al., 2011,

    The dawn of symbiosis between plants and fungi.

    , Biology Letters, ISSN: 1744-957X

    The colonization of land by plants relied on fundamental biological innovations, among which was symbiosis with fungi to enhance nutrient uptake. Here we present evidence that several species representing the earliest groups of land plants are symbiotic with fungi of the Mucoromycotina. This finding brings up the possibility that terrestrialization was facilitated by these fungi rather than, as conventionally proposed, by members of the Glomeromycota. Since the 1970s it has been assumed, largely from the observation that vascular plant fossils of the early Devonian (400 Ma) show arbuscule-like structures, that fungi of the Glomeromycota were the earliest to form mycorrhizas, and evolutionary trees have, until now, placed Glomeromycota as the oldest known lineage of endomycorrhizal fungi. Our observation that Endogone-like fungi are widely associated with the earliest branching land plants, and give way to glomeromycotan fungi in later lineages, raises the new hypothesis that members of the Mucoromycotina rather than the Glomeromycota enabled the establishment and growth of early land colonists.
  • Journal article
    Cosgrove S, Chotirmall SH, Greene CM, McElvaney NGet al., 2011,

    Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 7692-7704
  • Journal article
    Chotirmall SH, Low TB, Hassan T, Branagan P, Kernekamp C, Flynn MG, Gunaratnam C, McElvaney NGet al., 2011,

    Cystic fibrosis, common variable immunodeficiency and Aspergers syndrome: an immunological and behavioural challenge

    , IRISH JOURNAL OF MEDICAL SCIENCE, Vol: 180, Pages: 607-609, ISSN: 0021-1265
  • Journal article
    Griesenbach U, Soussi S, Larsen MB, Casamayor I, Dewar A, Regamey N, Bush A, Shah PL, Davies JC, Alton EWFWet al., 2011,

    Quantification of Periciliary Fluid Height in Human Airway Biopsies Is Feasible, but Not Suitable as a Biomarker

    , AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 44, Pages: 309-315, ISSN: 1044-1549
  • Journal article
    Ho KKC, Shamsuddin S-R, Riaz S, Lamorinere S, Tran MQ, Javaid A, Bismarck Aet al., 2011,

    Wet impregnation as route to unidirectional carbon fibre reinforced thermoplastic composites manufacturing

    , PLASTICS RUBBER AND COMPOSITES, Vol: 40, Pages: 100-107, ISSN: 1465-8011
  • Journal article
    Desai SR, Copley SJ, Barker RD, Elston CM, Miller RF, Wells AU, Munyati S, Nathoo K, Corbett EL, Ferrand RAet al., 2011,

    Chest radiography patterns in 75 adolescents with vertically-acquired human immunodeficiency virus (HIV) infection

    , CLINICAL RADIOLOGY, Vol: 66, Pages: 257-263, ISSN: 0009-9260
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    • Citations: 12

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