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• Journal article
  Holt RJ, Zhang Y, Binia A, Dixon AL, Vandiedonck C, Cookson WO, Knight JC, Moffatt MFet al., 2011,

  Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1).

  , Journal of Allergy and Clinical Immunology, Vol: 127, Pages: 1054-1062.e2, ISSN: 0091-6749

  Asthma is a common, chronic inflammatory airway disease of major public health importance with multiple genetic determinants. Previously, we found by positional cloning that PHD finger protein 11 (PHF11) on chromosome 13q14 modifies serum immunoglobulin E (IgE) concentrations and asthma susceptibility. No coding variants in PHF11 were identified.ObjectiveHere we investigate the 3 single nucleotide polymorphisms (SNPs) in this gene most significantly associated with total serum IgE levels—rs3765526, rs9526569, and rs1046295—for a role in transcription factor binding.MethodsWe used electrophoretic mobility shift assays to examine the effect of the 3 SNPs on transcription factor binding in 3 cell lines relevant to asthma pathogenesis. Relative preferential expression of alleles was investigated by using the allelotyping method.ResultsElectrophoretic mobility shift assays show that rs1046295 modulates allele-specific binding by the octamer-binding transcription factor 1 (Oct-1). Analysis of the relative expression levels of the 2 alleles of this SNP in heterozygous individuals showed a modest, but highly significant (P = 6.5 × 10−16), preferential expression of the A allele consistent with a functional role for rs1046295.ConclusionThese results suggest a mechanism by which rs1046295 may act as a regulatory variant modulating transcription at this locus and altering asthma susceptibility.

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• Journal article
  Hardwick KA, Fiedler P, Lee LC, Pavlik B, Hobbs RJ, Aronson J, Bidartondo M, Black E, Coates D, Daws MI, Dixon K, Elliott S, Ewing K, Gann G, Gibbons D, Gratzfeld J, Hamilton M, Hardman D, Harris J, Holmes PM, Jones M, Mabberley D, Mackenzie A, Magdalena C, Marrs R, Milliken W, Mills A, Lughadha EN, Ramsay M, Smith P, Taylor N, Trivedi C, Way M, Whaley O, Hopper SDet al., 2011,

  The role of botanic gardens in the science and practice of ecological restoration.

  , Conservation Biology, ISSN: 1523-1739

  Many of the skills and resources associated with botanic gardens and arboreta, including plant taxonomy, horticulture, and seed bank management, are fundamental to ecological restoration efforts, yet few of the world's botanic gardens are involved in the science or practice of restoration. Thus, we examined the potential role of botanic gardens in these emerging fields. We believe a reorientation of certain existing institutional strengths, such as plant-based research and knowledge transfer, would enable many more botanic gardens worldwide to provide effective science-based support to restoration efforts. We recommend botanic gardens widen research to include ecosystems as well as species, increase involvement in practical restoration projects and training practitioners, and serve as information hubs for data archiving and exchange.

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• Journal article
  Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HYK, Leng J, Li R, Li Y, Lin C-Y, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stuetz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JOet al., 2011,

  Mapping copy number variation by population-scale genome sequencing

  , NATURE, Vol: 470, Pages: 59-65, ISSN: 0028-0836
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  • Citations: 792
• Journal article
  Fainleib A, Grigoryeva O, Youssef B, Saiter JM, Bismarck Aet al., 2011,

  Modification of polycyanurate network by reactive rubbers with hydrazide, acylhydrazone and isocyanate terminal groups

  , Pages: 321-352

  First, chemical interactions between hydrazide, acylhydrazone and isocyanate groups from one side with cyanate groups from other side have been studied using methods of FTIR spectroscopy and NMR 1H analysis. The formation of the substituted cyanurate (triazine) cycles has been found. These results were confirmed on polymer systems at modification of polycyanurate network (PCN) by reactive rubbers, possessing the above mentioned functional groups, where the chemical reactions found led to incorporation of the rubbers into the PCN network. The partial chemical incorporation of the rubber modifiers' fragments into the PCN network structure has been found. The structure of the final hybrid networks was found to be depended on reactivity of the rubber modifier's functional groups toward cyanate groups and the modifier content in the system. It has been established that the unreacted part of the modifier forms the own separated microphase. The most pronounced two phase structure has been observed for OIDAH rubber with the lowest reactivity towards cyanate groups of the growing PCN network. © 2010 Nova Science Publishers, Inc. All rights reserved.

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• Journal article
  Quero F, Nogi M, Lee K-Y, Vanden Poel G, Bismarck A, Mantalaris A, Yano H, Eichhorn SJet al., 2011,

  Cross-Linked Bacterial Cellulose Networks Using Glyoxalization

  , ACS APPLIED MATERIALS & INTERFACES, Vol: 3, Pages: 490-499, ISSN: 1944-8244
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  • Citations: 51
• Journal article
  Garner TWJ, Rowcliffe JM, Fisher MC, 2011,

  Climate change, chytridiomycosis or condition: an experimental test of amphibian survival

  , GLOBAL CHANGE BIOLOGY, Vol: 17, Pages: 667-675, ISSN: 1354-1013
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  • Citations: 68
• Journal article
  Chotirmall SH, Mann AK, McElvaney NG, 2011,

  Invited commentary: The decision to withdraw treatment and its optimal method are not mutually exclusive (vol 25, pg 652, 2010)

  , JOURNAL OF CRITICAL CARE, Vol: 26, Pages: 109-109, ISSN: 0883-9441
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• Journal article
  Singanayagam A, Scally C, Al-Khairalla MZ, Leitch L, Hill LE, Chalmers JD, Hill ATet al., 2011,

  Are biomarkers additive to pulmonary embolism severity index for severity assessment in normotensive patients with acute pulmonary embolism?

  , QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 104, Pages: 125-131, ISSN: 1460-2725
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  • Citations: 28
• Journal article
  Chalmers JD, Singanayagam A, Akram AR, Choudhury G, Mandal P, Hill ATet al., 2011,

  Safety and efficacy of CURB65-guided antibiotic therapy in community-acquired pneumonia

  , JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 66, Pages: 416-423, ISSN: 0305-7453
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  • Citations: 41
• Conference paper
  Cota E, 2011,

  Als adhesins - Structural basis for the broad specificity to host-cell ligands by Candida albicans

  , Host-fungal interactions: pathogenicity versus immunity, Pages: 149-151

  Als (agglutinin-like sequence) glycoproteins have been associated with binding of host-cell surface proteins and small peptides of random sequence, the formation of biofilms and amyloid fibers. High-resolution structures of N-terminal Als domains show that ligand recognition relies on a motif capable of binding flexible C termini of peptides in extended conformation. These data establish NT-Als adhesins as a separate family of peptide-binding proteins and an unexpected adhesion system for primary, widespread protein–protein interactions at the Candida/host-cell interface. The new structural information also provides potential templates for the design of novel antifungals.

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