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  • Journal article
    Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN, Haynes Ket al., 2007,

    Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection

    , PLoS Pathogens, Vol: 3

    Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen. We have previously demonstrated that A. fumigatus excretes fusarinine C and triacetylfusarinine C to capture extracellular iron, and uses ferricrocin for hyphal iron storage. Here, we delineate pathways of intra- and extracellular siderophore biosynthesis and show that A. fumigatus synthesizes a developmentally regulated fourth siderophore, termed hydroxyferricrocin, employed for conidial iron storage. By inactivation of the nonribosomal peptide synthetase SidC, we demonstrate that the intracellular siderophores are required for germ tube formation, asexual sporulation, resistance to oxidative stress, catalase A activity, and virulence. Restoration of the conidial hydroxyferricrocin content partially rescues the virulence of the apathogenic siderophore null mutant DeltasidA, demonstrating an important role for the conidial siderophore during initiation of infection. Abrogation of extracellular siderophore biosynthesis following inactivation of the acyl transferase SidF or the nonribosomal peptide synthetase SidD leads to complete dependence upon reductive iron assimilation for growth under iron-limiting conditions, partial sensitivity to oxidative stress, and significantly reduced virulence, despite normal germ tube formation. Our findings reveal distinct cellular and disease-related roles for intra- and extracellular siderophores during mammalian Aspergillus infection.
  • Journal article
    Menner A, Ikem V, Salgueiro M, Shaffer MSP, Bismarck Aet al., 2007,

    High internal phase emulsion templates solely stabilised by functionalised titania nanoparticles

    , CHEMICAL COMMUNICATIONS, Pages: 4274-4276, ISSN: 1359-7345
  • Journal article
    Gray RD, Horsley A, Macleod K, Imrie M, Dewar M, Voase N, Donovan J, Hyde S, Gill D, Griesenbach U, Davies JC, Alton E, Boyd AC, Porteous D, Cunningham S, Innes JA, Greening APet al., 2007,

    UKCF gene therapy consortium tracking study: Sputum and serum calprotectin are useful novel measurements in CF exacerbation

    , PEDIATRIC PULMONOLOGY, Pages: 338-338, ISSN: 8755-6863
  • Book chapter
    Fisher MC, 2007,

    The evolutionary implications of an asexual lifestyle manifested by Penicillium marneffei.

    , Sex in fungi: molecular determination and evolutionary implications, Editors: Heitman, Kronstad, Taylor, Casselton, Publisher: ASM Press
  • Conference paper
    Davies JC, 2007,

    Invasive and non-invasive markers of airway inflammation

    , 21st Annual North American Cystic Fibrosis Conference, Publisher: WILEY-LISS, Pages: 177-178, ISSN: 8755-6863
  • Journal article
    Tintelnot K, De Hoog GS, Antweiler E, Losert H, Seibold M, Brandt MA, Van den Ende AHGG, Fisher MCet al., 2007,

    Taxonomic and diagnostic markers for identification of <i>Coccidioides immitis</i> and <i>Coccidioides posadasii</i>

    , MEDICAL MYCOLOGY, Vol: 45, Pages: 385-393, ISSN: 1369-3786
  • Journal article
    Juntaro J, Pommet M, Mantalaris A, Shaffer M, Bismarck Aet al., 2007,

    Nanocellulose enhanced interfaces in truly green unidirectional fibre reinforced composites

    , COMPOSITE INTERFACES, Vol: 14, Pages: 753-762, ISSN: 0927-6440
  • Journal article
    Reizarney N, Tsartsali L, Hilliard TN, Cornish N, Zhu J, Jeffery PK, Alton EW, Bush A, Davies JCet al., 2007,

    Airway mucosa inflammation in children with cystic fibrosis

    , PEDIATRIC PULMONOLOGY, Pages: 262-263, ISSN: 8755-6863
  • Journal article
    Regamey N, Ochs M, Hilliard TN, Muehlfeld C, Cornish N, Fleming L, Saglani S, Alton EW, Bush A, Jeffery P, Davies JCet al., 2007,

    Airway smooth muscle remodeling in children with cystic fibrosis

    , PEDIATRIC PULMONOLOGY, Pages: 349-350, ISSN: 8755-6863
  • Conference paper
    Ryall B, Davies JC, Wilson R, Shoemark A, Williams HDet al., 2007,

    Cyanide accumulates in the sputum of Pseudomonas aeruginosa-infected cystic fibrosis and non-cystic, fibrosis bronchiectasis patients and is associated with impaired lung function

    , Publisher: WILEY-LISS, Pages: 327-327, ISSN: 8755-6863

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