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  • Conference paper
    Goldstein DB, Foote SJ, Hafler DA, Daly MJ, Kere J, Abbas AK, Goodnow CC, Seed B, Rioux JD, Wakeland EK, Cookson Wet al., 2005,

    Discussion

    , Pages: 39-45, ISSN: 1528-2511
  • Conference paper
    Abbas AK, Wijmenga C, Rioux JD, Seed B, Cookson W, Goodnow CC, Bowcock A, Umetsu D, Hafler DA, Kuchroo VK, Wakeland EK, Lindgren C, Ting J, Wicker LS, Vyse TJet al., 2005,

    Discussion

    , Pages: 134-144, ISSN: 1528-2511
  • Conference paper
    Wakeland EK, Goodnow CC, Kuchroo VK, Seed B, Hafler DA, Cookson W, Abbas AK, Behrens TW, Rioux JD, Umetsu D, Foote SJ, Bowcock A, Kere J, Wicker LS, Rao Aet al., 2005,

    Discussion

    , Pages: 212-218, ISSN: 1528-2511
  • Conference paper
    Goldstein DB, Abbas AK, Wijmenga C, Cookson W, Goodnow CC, Rioux JD, Hafler DA, Kere J, Daly MJ, Bowcock A, Behrens TW, Foote SJ, Worthington Jet al., 2005,

    Discussion

    , Pages: 8-13, ISSN: 1528-2511
  • Conference paper
    Wakeland EK, Goodnow CC, Cookson W, Abbas AK, Rioux JD, Foote SJ, Bowcock A, Kere J, Ting Jet al., 2005,

    Discussion

    , Pages: 239-241, ISSN: 1528-2511
  • Conference paper
    Hafler DA, Rao A, Ting J, Rioux JD, Goodnow CC, Abbas AK, Wicker LS, Wakeland EK, Behrens TW, Goldstein DB, Kere J, Cookson W, Seed B, Lindgren C, Bowcock A, Kuchroo VKet al., 2005,

    Discussion

    , Pages: 174-179, ISSN: 1528-2511
  • Journal article
    Hollax EJ, Davies J, Griesenbach U, Burgess J, Alton EW, Armour JAet al., 2005,

    Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis

    , J Negat Results Biomed, Vol: 7
  • Journal article
    Hilliard T, Edwards S, Buchdahl R, Francis J, Rosenthal M, Balfour-Lynn I, Bush A, Davies Jet al., 2005,

    Voriconazole therapy in children with cystic fibrosis.

    , J Cyst Fibros, Vol: 4, Pages: 215-220, ISSN: 1569-1993

    BACKGROUND: There is increasing evidence for the efficacy of the antifungal voriconazole, particularly in immunosuppression. We describe our experience of using voriconazole in children with CF. METHODS: We performed a retrospective case note review of children with CF treated with voriconazole in a single centre over an 18 month period. RESULTS: A total of 21 children aged 5 to 16 years (median 11.3) received voriconazole for between 1 and 50 (22) weeks. Voriconazole was used as monotherapy in 2 children with recurrent allergic bronchopulmonary aspergillosis (ABPA); significant and sustained improvements in clinical and serological parameters for up to 13 months were observed, without recourse to oral steroids. Voriconazole was used in combination with an immunomodulatory agent in a further 11 children with ABPA, with significant improvement in pulmonary function and serology. 8 children without ABPA but who had recurrent Aspergillus fumigatus isolates and increased symptoms also received voriconazole; this group did not improve with treatment. Adverse effects occurred in 7 children (33%: photosensitivity reaction 3, nausea 2, rise in hepatic enzymes 1, hair loss 1). CONCLUSIONS: Voriconazole may be a useful adjunctive therapy for ABPA in CF. Voriconazole monotherapy appears to be an alternative treatment strategy when oral corticosteroids may not be suitable.

  • Journal article
    Aziz ZA, Wells AU, Desai SR, Ellis SM, Walker AE, MacDonald S, Hansell DMet al., 2005,

    Functional impairment in emphysema: Contribution of airway abnormalities and distribution of parenchymal disease

    , AMERICAN JOURNAL OF ROENTGENOLOGY, Vol: 185, Pages: 1509-1515, ISSN: 0361-803X
  • Journal article
    Safinia L, Datan N, Höhse M, Mantalaris A, Bismarck Aet al., 2005,

    Towards a methodology for the effective surface modification of porous polymer scaffolds

    , BIOMATERIALS, Vol: 26, Pages: 7537-7547, ISSN: 0142-9612

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