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  • Conference paper
    Cookson WOCM, Abeçasis GR, 2001,

    Oxford genome screen for asthma-associated traits

    , Pages: S1-S3, ISSN: 0741-0395

    A genome screen for linkage of quantitative traits underlying asthma has been carried out previously by our group on 80 families sub-selected for discordant phenotypes from a general population sample. The families contained a total of 203 offspring forming 172 sib-pairs. Genotypic data for at a total of 296 markers were available. This paper describes the ascertainment, phenotypic data, and genotypic data made available for Genetic Analysis Workshop 12. © 2001 Wiley-Liss, Inc.
  • Journal article
    Denison SH, Negrete-Urtasun S, Mingot JM, Tilburn J, Mayer WA, Goel A, Espeso EA, Peñalva MA, Arst HNet al., 2001,

    Putative membrane components of signal transduction pathways for ambient pH regulation in <i>Aspergillus</i> and meiosis in <i>Saccharomyces</i> are homologous (vol 30, pg 259, 1998)

    , MOLECULAR MICROBIOLOGY, Vol: 39, Pages: 211-211, ISSN: 0950-382X
  • Journal article
    Nicholas HB, Arst HN, Caddick MX, 2001,

    Evaluating low level sequence identities - Are <i>Aspergillus</i> QUTA and AROM homologous?

    , EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 268, Pages: 414-419, ISSN: 0014-2956
  • Journal article
    Nicholas HB, Arst HN, Caddick MX, 2001,

    Evaluating low level sequence identities

    , European Journal of Biochemistry, Vol: 268, Pages: 414-419, ISSN: 0014-2956

    <jats:p>A review published several years ago [Hawkins, A.R. &amp; Lamb, H.K. (1995) <jats:italic>Eur. J. Biochem</jats:italic>. <jats:bold>232</jats:bold>, 7–18] proposed that genetic, biochemical and physiological data can override sequence comparison in the determination of homology in instances where structural information is unavailable. Their lead example was the hypothesis that the transcriptional activator protein for quinate catabolism in <jats:italic>Aspergillus nidulans</jats:italic>, QUTA, is derived from the pentafunctional AROM protein by a gene duplication followed by cleavage [Hawkins, A.R., Lamb, H.K., Moore, J.D. &amp; Roberts, C.F. (1993) <jats:italic>Gene</jats:italic><jats:bold>136</jats:bold>, 49–54]. We tested this hypothesis by a sensitive combination of position‐specific log‐odds scoring matrix methods. The position‐specific log‐odds scoring matrices were derived from a large number of 3‐dehydroquinate synthase and 5‐<jats:italic>enol</jats:italic>pyruvylshikimate‐3‐phosphate synthase domains that were proposed to be the domains from the AROM protein that gave rise to the transcriptional activator protein for quinate metabolism. We show that the degree and pattern of similarity between these position‐specific log‐odds scoring matrices and the transcriptional activator protein for quinate catabolism in <jats:italic>A. nidulans</jats:italic> is that expected for random sequences of the same composition. This level of similarity provides no support for the suggested gene duplication and cleavage. The lack of any trace of evidence for homology following a comprehensive sequence analysis indicates that the homology hypothesis is without foundation, underlining the necessity to accept only similarity of sequence and/or structure as evidence of evolutionary relatedness. Further, QUTA is homologous throughout its entire length
  • Journal article
    Scheid P, Kempster L, Griesenbach U, Davies JC, Dewar A, Weber PP, Colledge WH, Evans MJ, Geddes DM, Alton EWFWet al., 2001,

    Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 17, Pages: 27-35, ISSN: 0903-1936
  • Conference paper
    Wielage B, Lampke T, Bismarck A, 2001,

    Oberflächensensitive Methoden zur Einschätzung des Verstärkungspotenzials von Naturfasern

    , Verbundwerkstoffe und Werkstoffverbunde, Tagung, Chemnitz, Germany, September 2001, Publisher: Wiley-VCH, Pages: 454-460
  • Journal article
    Ramanathan T, Bismarck A, Schulz E, Subramanian Ket al., 2001,

    Investigation of the influence of surface-activated carbon fibres on debonding energy and frictional stress in polymer-matrix composites by the micro-indentation technique

    , COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 61, Pages: 2511-2518, ISSN: 0266-3538
  • Journal article
    Davies J, Turner M, Klein N, 2001,

    The role of the collectin system in pulmonary defence

    , Paediatr Respir Rev, Pages: 70-75, ISSN: 1526-0542
  • Journal article
    Nielsen PS, Clark AJ, Oliver RP, Huber M, Spanu PDet al., 2001,

    HCf-6, a novel class II hydrophobin from <i>Cladosporium fulvum</i>

    , MICROBIOLOGICAL RESEARCH, Vol: 156, Pages: 59-63, ISSN: 0944-5013
    • Cite
    • Citations: 22
  • Journal article
    Ramanathan T, Bismarck A, Schulz E, Subramanian Ket al., 2001,

    Investigation of the influence of acidic and basic surface groups on carbon fibres on the interfacial shear strength in an epoxy matrix by means of single-fibre pull-out test

    , COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 61, Pages: 599-605, ISSN: 0266-3538

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