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Journal articleRamanathan T, Bismarck A, Schulz E, et al., 2001,
The use of a single-fibre pull-out test to investigate the influence of acidic and basic surface groups on carbon fibres on the adhesion to poly(phenylene sulfide) and matrix-morphology-dependent fracture behaviour
, COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 61, Pages: 1703-1710, ISSN: 0266-3538- Author Web Link
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- Citations: 32
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Journal articleCherny SS, Abecasis GR, Cookson WOC, et al., 2001,
The effect of genotype and pedigree error on linkage analysis: Analysis of three asthma genome scans
, GENETIC EPIDEMIOLOGY, Vol: 21, Pages: S117-S122, ISSN: 0741-0395- Author Web Link
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- Citations: 18
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Journal articleDavies JC, Geddes DM, Alton EWFW, 2001,
Gene therapy for cystic fibrosis
, JOURNAL OF GENE MEDICINE, Vol: 3, Pages: 409-417, ISSN: 1099-498X- Author Web Link
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- Citations: 45
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Journal articleBhattacharyya S, Leaves NI, Wiltshire S, et al., 2000,
A high-density genetic map of the chromosome 13q14 atopy locus
, GENOMICS, Vol: 70, Pages: 286-291, ISSN: 0888-7543- Cite
- Citations: 12
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Journal articleDavies MG, Davies JC, Geddes DM, et al., 2000,
Nasal epithelial pH is lower in patients with cystic fibrosis.
, THORAX, Vol: 55, Pages: A66-A66, ISSN: 0040-6376 -
Journal articleEwig S, Schäfer H, Torres A, 2000,
Severity assessment in community-acquired pneumonia.
, Eur Respir J, Vol: 16, Pages: 1193-1201, ISSN: 0903-1936In current guidelines for the management of adults with community-acquired pneumonia (CAP), the triaging decision about hospitalization or intensive care unit (ICU) admission, and, as a consequence, selection of initial antimicrobial treatment is largely based on the assessment of pneumonia severity. The proposed severity criteria are mainly derived from studies determining predictors of adverse outcome. These include age, male sex, comorbidity, acute respiratory failure, severe sepsis and septic shock, extension of radiographic infiltrates, bacteraemia and CAP through several different pathogens such as Streptococcus pneumoniae, Staphylococcus aureus, Gram-negative enteric bacilli (GNEB), and signs of disease progression within the first 48-72 h. In addition, prediction rules and need for a complicated course in ambulatory and hospitalized patients, for the individual risk of death have been developed which may be helpful in determining the patient who might require hospitalization or intensive care, respectively. Risk classifications such as the scores developed by FINE et al. [40] are not only useful for identifying low risk patients who might safely be treated as outpatients, but apparently they will also play a major role in the evaluation of processes and outcomes of care for patients with CAP. Recent investigations have provided objective criteria for the definition of severe CAP requiring ICU admission. Whether the detection of infiltrates in the chest radiographs of patients with acute lower respiratory tract infection (LRTI) suggestive of mild pneumonia has an independent prognostic impact which fundamentally affects the concept of mild LRTI remains to be seen. Based on objective criteria for severity assessment it will be possible to define interventions aimed at reducing hospital admission rates, define a risk-adapted antimicrobial treatment regimen, reduce costs for antimicrobial treatment and supportive measures, shorten hospital stay, and, thereby, im
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Journal articleEwig S, Schäfer H, Torres A, 2000,
Severity assessment in community-acquired pneumonia
, EUROPEAN RESPIRATORY JOURNAL, Vol: 16, Pages: 1193-1201, ISSN: 0903-1936- Author Web Link
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- Citations: 33
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Journal articleKretzer AM, Bidartondo MI, Grubisha LC, et al., 2000,
Regional specialization of Sarcodes sanguinea (Ericaceae) on a single fungal symbiont from the Rhizopogon ellenae (Rhizopogonaceae) species complex
, American Journal of Botany, Vol: 87, Pages: 1778-1782, ISSN: 0002-9122We have sampled the mycorrhizal roots of 76 snow plants (Sarcodes sanguinea, Monotropoideae, Ericaceae) in two areas of the Sierra Nevada of California that are similar to 180 km apart. To identify the fungal symbionts associated with these plants, we first analyzed restriction fragment length polymorphisms (RFLPs) of the internal transcribed spacer region (TTS) of the Fun ai nuclear ribosomal repeat. Fungal ITS-RFLPs were successfully produced from 57 of the 76 plants sampled, and all symbionts shared the same DNA fragment pattern. The morphology of S. sanguinea mycorrhizae was consistent with that expected from a Rhizopogon species in section Amylopogon. To confirm and refine this identification, a total of six fungal ITS sequences were determined from S. sanguinea mycorrhizae. These sequences were analyzed together with right existing and eight newly determined ITS sequences from Rhizopogon section Amylopogon. The newly determined sequences include an ITS sequence from the fungal symbiont of pine drops (Pterospora andromedea, Monotropoideae, Ericaceae), a plant that was previously reported to he exclusively associated with the Rhizopogon subcaerulescens group. When these sequences were analyzed together the Sarcodes symbionts grouped tightly with several collections of R. ellenae including the holotype, one collection of R. idahoensis, and one collection of R. semireticulatus. A different lineage comprised collections of R. subgelatinosus. R. subcaerulescens, another collection of R. semireticulatus, and the Pterospora symbiont. We conclude that S. sanguinea associates exclusively with a single species in the R. ellenae species complex throughout our sampling range. These results indicate a much higher level of specificity in S. sanguinea than was previously reported and confirm the emerging pattern that nonphotosynthetic, monotropoid plants generally associate very specifically with a narrow range of ectomycorhizal fungi.
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Journal articleDavies JC, Davies MG, Smith S, et al., 2000,
Confirmation of abnormal chloride ion secretion in the lower airway of children with cystic fibrosis
, THORAX, Vol: 55, Pages: A67-A67, ISSN: 0040-6376 -
Journal articleBidartondo MI, Kretzer AM, Pine EM, et al., 2000,
High root concentration and uneven ectomycorrhizal diversity near Sarcodes sanguinea (Ericaceae): A cheater that stimulates its victims?
, American Journal of Botany, Vol: 87, Pages: 1783-1788, ISSN: 0002-9122Sarcodes sanguinea is a nonphotosynthetic mycoheterotrophic plant that obtains all of its fixed carbon from neighboring trees through a shared ectomycorrhizal fungus. We studied the spatial structuring of this tripartite symbiosis in a forest where Sa,codes is abundant, and its only fungal and photosynthetic plant associates are Rhizopogon ellenae and Abies magnifica, respectively. We found disproportionately high concentrations of Abies roots adjacent to Sarcodes roots compared to the surrounding soil. Rhizopogon ellenae colonizes the vast majority of those Abies roots (86-98%), and its abundance tends to decrease with increasing distance from Sarcodes plants. At 500 cm from Sarcodes plants we did not detect R, ellenae, and the ectomycorrhizal community instead was dominated by members of the Russulaceae and Thelephoraceae, which are commonly dominant in other California pinaceous forests. The highly clumped distribution of Abies-R. ellenae ectomycorrhizas indicates that Sarcodes plants either establish within pre-existing clumps, or they stimulate clump formation. Several lines of evidence favor the latter interpretation, suggesting an unexpected mutualistic aspect to the symbiosis. However, the mechanism involved remains unknown.
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