Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    STAFFORD AN, RIDER SH, HOPKIN JM, COOKSON WO, MONACO APet al., 1994,

    A 2.8 MB YAC CONTIG IN 11Q12-Q13 LOCALIZES CANDIDATE GENES FOR ATOPY - FC-EPSILON-RI-BETA AND CD20

    , HUMAN MOLECULAR GENETICS, Vol: 3, Pages: 779-785, ISSN: 0964-6906
  • Journal article
    Young RP, Dekker JW, Wordsworth BP, Schou C, Pile KD, Matthiesen F, Rosenberg WM, Bell JI, Hopkin JM, Cookson WOet al., 1994,

    HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens.

    , Clin Exp Allergy, Vol: 24, Pages: 431-439, ISSN: 0954-7894

    In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR1 was found in subjects who were responsive to Fel d I compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1.9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phl p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.
  • Journal article
    DESAI SR, WELLS AU, CHEAH FK, COLE PJ, HANSELL DMet al., 1994,

    THE REPRODUCIBILITY OF BRONCHIAL CIRCUMFERENCE MEASUREMENTS USING COMPUTED-TOMOGRAPHY

    , BRITISH JOURNAL OF RADIOLOGY, Vol: 67, Pages: 257-262, ISSN: 0007-1285
  • Journal article
    Fowler PA, Fraser M, Cunningham P, Knight PG, Byrne B, McLaughlin EA, Wardle PG, Hull MG, Templeton Aet al., 1994,

    Higher gonadotrophin surge-attenuating factor bioactivity is found in small follicles from superovulated women

    , Journal of Endocrinology, Vol: 143, Pages: 33-44

    Ovine and rat pituitary bioassays for gonadotrophin surge-attenuating factor (GnSAF) were utilized to determine whether the level of GnSAF bioactivity in pooled human follicular fluid (hFF) from superovulated women varied according to follicle diameter (< or = 11 mm, 12-15 mm and 16-21 mm follicles examined using the ovine bioassay, or < or = 10 mm, 11-13 mm, 14-17 mm, 18-20 mm, 21-24 mm and > or = 25 mm follicles examined using the rat bioassay). When tested using dispersed ovine pituitary cells, GnSAF bioactivity, expressed in terms of the reduction in gonadotrophin-releasing hormone (GnRH)-induced LH secretion, was inversely related to follicle diameter (P < 0.01). In response to 5 microliters hFF/well from follicles of < or = 11, 12-15 and 16-21 mm diameter, GnRH-induced LH secretion was reduced to 40.5 +/- 6.9%, 65.2 +/- 6.6% and 83.7 +/- 7.9% of control respectively. A similar inverse relationship was observed when a second batch of hFF samples from different sized follicles was tested using rat pituitary cell monolayers. Expressing GnSAF bioactivity in terms of the dose required to suppress GnRH-induced LH secretion by rat pituitary cells to 50% of the maximal suppression observed (ED50), the three smallest follicle size pools contained the most GnSAF (ED50 values of 0.13, 2.79 and 5.36 microliters hFF/well from follicles of < or = 10, 11-13 and 14-17 mm respectively). The ED50 values for follicles of 18-20, 21-24 and > or = 25 mm were 8.81, 27.1 and 60.0 microliters hFF/well respectively. Thus hFF from follicles < or = 11 mm was over 450 times more potent than hFF from follicles > or = 25 mm in suppressing GnRH-induced LH release. The ED50 values for inhibin bioactivity (measured as the suppression of basal FSH secretion from rat pituitary monolayers) were much less variable than those for GnSAF bioactivity (between 0.85 and 0.13 microliters hFF/well). Inhibin immunoreactivity, measured by a two-site immunoradiometric assay, follow
  • Journal article
    DIALLINAS G, GORFINKIEL L, ARST HN, CECCHETTO G, SCAZZOCCHIO Cet al., 1994,

    GENETIC AND MOLECULAR CHARACTERIZATION OF PURINE PERMEASE GENES OF ASPERGILLUS-NIDULANS REVEALS A NOVEL FAMILY OF TRANSPORTERS CONSERVED IN PROKARYOTES AND EUKARYOTES

    , FOLIA MICROBIOLOGICA, Vol: 39, Pages: 513-514, ISSN: 0015-5632
  • Journal article
    Arst HN, 1994,

    Regulation of gene expression by oxygen, phosphorus and pH.

    , Prog Ind Microbiol, Vol: 29, Pages: 369-380, ISSN: 0079-6352
  • Journal article
    Fowler PA, Cunningham P, Fraser M, MacGregor F, Byrne B, Pappas A, Messinis IE, Templeton Aet al., 1994,

    Ciruclating gonadotrphin surge attenuating factor from superovulated women suppresses in vitro gonadotrophin-releasing hormone self-priming

    , Journal of Endocrinology, Vol: 143, Pages: 45-54

    A perifusion system based on ovine pituitary tissue explants was used to investigate the effects of follicular fluid (hFF) and serum from superovulated women on pituitary responsiveness to gonadotrophin-releasing hormone (GnRH). The specific aims of the study were to determine both if gonadotrophin surge-attenuating factor (GnSAF) bioactivity is present in the peripheral circulation as well as in the follicles of superovulated women and if GnSAF suppresses GnRH self-priming in vitro. Two pulses of GnRH, 1 h apart, produced marked peaks in LH secreted from control chambers, with GnRH self-priming evident in the significant difference between the first (134.4 +/- 1.7 - 232.1 +/- 24.0% of basal secretion) and second (183.9 +/- 15.8 - 313.9 +/- 14.0% of basal secretion) LH peaks. Both follicular fluid and serum pooled from two different groups of women produced marked suppression of the first (unprimed) and second (primed) LH peaks. The hFF reduced the first LH peak to 69.6 +/- 7.8 and 60.2 +/- 9.7% and the second LH peak to 57.4 +/- 6.7 and 42.6 +/- 6.5% of control LH secretion. Overall, the serum reduced the first and second LH peaks to 76.8 +/- 4.2 and 62.9 +/- 3.6% of control respectively. These results demonstrated that GnSAF bioactivity suppresses GnRH self-priming, and is present in both the peripheral circulation and hFF. The same material administered to dispersed ovine pituitary monolayers produced similar marked suppression of GnRH-induced LH secretion, with approximately 50-fold less GnSAF bioactivity in serum compared with hFF. Combined doses of oestradiol and progesterone, or hFF from large follicles containing little GnSAF, produced stimulation of GnRH-induced LH secretion and GnRH self-priming (second peaks 78.1 +/- 38.9 and 27.4 +/- 15.7% respectively higher than first peaks). Thus, in conclusion, GnSAF in hFF and serum markedly attenuated both unprimed and primed pituitary response to GnRH, virtually abolishing the GnRH self-priming effect.
  • Journal article
    ESPESO EA, TILBURN J, ARST HN, PENALVA MAet al., 1993,

    PH REGULATION IS A MAJOR DETERMINANT IN EXPRESSION OF A FUNGAL PENICILLIN BIOSYNTHETIC GENE

    , EMBO JOURNAL, Vol: 12, Pages: 3947-3956, ISSN: 0261-4189
  • Journal article
    de Klerk NH, Musk AW, Cookson WO, Glancy JJ, Hobbs MSet al., 1993,

    Radiographic abnormalities and mortality in subjects with exposure to crocidolite.

    , Br J Ind Med, Vol: 50, Pages: 902-906, ISSN: 0007-1072

    Plain chest radiographs from a one in six random sample of the workforce of the asbestos industry at Wittenoom, Western Australia between 1943 and 1966 have been classified for degree of profusion and pleural thickening by two independent observers according to the 1980 UICC-ILO Classification of Radiographs for the pneumoconioses to clarify the effect of degree of radiological abnormality on survival. A total of 1106 subjects were selected. Each subject's age, cumulative exposure to crocidolite, and time since first exposure were determined from employment records, the results of a survey of airborne concentrations of fibres > 5 mu in length conducted in 1966, and an exposure rating by an industrial hygienist and an ex-manager of the mine and mill at Wittenoom. By the end of 1986 193 subjects had died. Conditional logistic regression was used to model the relative risk of death in five separate case-control analyses in which the outcomes were deaths from: (1) all causes, (2) malignant mesothelioma, (3) lung cancer, (4) asbestosis, and (5) other causes excluding cancer and asbestosis. Up to 20 controls per case were randomly chosen from all men of the same age who were not known to have died before the date of death of the index case. After adjustment for exposure and time since first exposure, there were significant and independent effects of radiographic profusion and pleural thickening on all cause mortality. The effect of profusion was largely a result of the effect on mortality from malignant mesothelioma and asbestosis but not lung cancer. The effect of pleural thickening was greatest on mortality from other causes, mainly ischaemic heart disease. This study has shown that degree of radiographic abnormality has an independent effect on mortality from malignant mesothelioma, asbestosis, and all causes even after allowing for the effects of age, degree of exposure, and time since first exposure.
  • Journal article
    MACRAE WD, BUXTON FP, SIBLEY S, GARVEN S, GWYNNE DI, ARST HN, DAVIES RWet al., 1993,

    CHARACTERIZATION OF AN ASPERGILLUS-NIDULANS GENOMIC DNA FRAGMENT CONFERRING PHOSPHATE-NON-REPRESSIBLE ACID-PHOSPHATASE-ACTIVITY

    , GENE, Vol: 130, Pages: 247-251, ISSN: 0378-1119

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1255&limit=10&resgrpMemberPubs=true&resgrpMemberPubs=true&page=462&respub-action=search.html Current Millis: 1765368656992 Current Time: Wed Dec 10 12:10:56 GMT 2025

General enquiries

 For any enquiries about the Fungal Science Network at Imperial, please contact:

fungalnetwork@imperial.ac.uk