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• Journal article
  KUDLA B, CADDICK MX, LANGDON T, MARTINEZROSSI NM, BENNETT CF, SIBLEY S, DAVIES RW, ARST HNet al., 1990,

  THE REGULATORY GENE AREA MEDIATING NITROGEN METABOLITE REPRESSION IN ASPERGILLUS-NIDULANS - MUTATIONS AFFECTING SPECIFICITY OF GENE ACTIVATION ALTER A LOOP RESIDUE OF A PUTATIVE ZINC FINGER

  , EMBO JOURNAL, Vol: 9, Pages: 1355-1364, ISSN: 0261-4189
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  • Citations: 399
• Conference paper
  SPANU P, BONFANTEFASOLO P, BOLLER T, 1990,

  CHITINASE ACTIVITY AND VA-MYCORRHIZA DEVELOPMENT

  , 2ND EUROPEAN SYMP ON MYCORRHIZAE : ECOLOGICAL AND APPLIED ASPECTS OF ECTOMYCORRHIZAL AND ENDOMYCORRHIZAL ASSOCIATIONS, Publisher: ELSEVIER SCIENCE BV, Pages: 409-413, ISSN: 0167-8809
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  • Citations: 2
• Journal article
  de Klerk NH, Musk AW, James A, Glancy JJ, Cookson WOet al., 1990,

  Comparison of chest radiograph reading methods for assessing progress of pneumoconiosis over 10 years in Wittenoom crocidolite workers.

  , Br J Ind Med, Vol: 47, Pages: 127-131, ISSN: 0007-1072

  Thirty three pairs of chest radiographs taken up to 10 years apart were obtained for 33 subjects suffering from asbestosis who had applied for compensation to the Pneumoconiosis Medical Board of Western Australia. Multiple films from the period before the first radiograph in each pair, from the intervening period between the two, and from the period subsequent to the second radiograph were also available and all films were read by two independent readers according to the 1980 ILO classification of pneumoconiosis. Films were read twice as side by side pairs ten years apart, twice as two separate randomly ordered films ten years apart, and once as part of the full series of all available chest radiographs on each subject to assess which method provided the best consistency (between reader variation) and repeatability (within reader variation). Judging by consistency, the full series method performed as well as either of the other methods when assessing radiographic changes and significantly better when assessing the level of profusion of small opacities. There was little to choose between the other two methods either judging by consistency or repeatability, which could not be estimated for the full series method. Use of all available films for a subject is recommended for assessing single films, as in a prevalence study, as well as for documenting change in a longitudinal study.

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• Journal article
  ROSSI A, ARST HN, 1990,

  MUTANTS OF ASPERGILLUS-NIDULANS ABLE TO GROW AT EXTREMELY ACIDIC PH ACIDIFY THE MEDIUM LESS THAN WILD-TYPE WHEN GROWN AT MORE MODERATE PH

  , FEMS MICROBIOLOGY LETTERS, Vol: 66, Pages: 51-53, ISSN: 0378-1097
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  • Citations: 22
• Journal article
  Rossi A, Arst HN, 1990,

  Mutants of Aspergillus nidulans able to grow at extremely acidic pH acidify the medium less than wild type when grown at more moderate pH.

  , FEMS Microbiol Lett, Vol: 54, Pages: 51-53, ISSN: 0378-1097

  Mutations conferring the ability to grow on extremely acidic media have been selected in the fungus Aspergillus nidulans and map to at least four genes. The mutations fall into two classes: those that confer acid resistance in media of both high and low buffering capacity and those that confer resistance only in media of low buffering capacity. In growth media of more moderate pH mutations of both classes result in reduced acidification of the medium.

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• Book chapter
  Arst HN, 1990,

  Wide domain regulation of gene expression in Aspergillus nidulans with special attention to the role of the meaB gene

  , 6th International Symposium on Genetics of Industrial Microorganisms (GIM 90) Proceedings, Editors: Heslot, Davies, Florent, Bobichon, Durand, Penasse, Paris, Publisher: Societe Francaise de Microbiologie, Pages: 555-556
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• Journal article
  ARST HN, KUDLA B, MARTINEZROSSI N, CADDICK MX, SIBLEY S, DAVIES RWet al., 1989,

  ASPERGILLUS AND MOUSE SHARE A NEW CLASS OF ZINC FINGER PROTEIN

  , TRENDS IN GENETICS, Vol: 5, Pages: 291-291, ISSN: 0168-9525
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  • Citations: 21
• Journal article
  SPANU P, BOLLER T, 1989,

  ETHYLENE BIOSYNTHESIS IN TOMATO PLANTS INFECTED BY PHYTOPHTHORA-INFESTANS

  , JOURNAL OF PLANT PHYSIOLOGY, Vol: 134, Pages: 533-537, ISSN: 0176-1617
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  • Citations: 41
• Journal article
  Durham SR, Keenan J, Cookson WO, Craddock CF, Benson MKet al., 1989,

  Diurnal variation in serum cortisol concentrations in asthmatic subjects after allergen inhalation.

  , Thorax, Vol: 44, Pages: 582-585, ISSN: 0040-6376

  To assess whether differences in the adrenal response to allergen are important in determining the magnitude of the allergen induced late responses in asthmatic subjects, we measured serum cortisol concentrations after inhalation challenge with allergen or control solution (phosphate buffered saline). The two challenges were performed in random order with an interval of 14 days. A normal diurnal decrease in serum cortisol concentrations was observed on both days. Mean blood cortisol concentrations three hours after inhalation of allergen (before the late response), nine hours afterwards (at the time of the late response), and 24 hours afterwards were virtually identical to those observed after inhalation of phosphate buffered saline. Serum cortisol concentrations before challenge and three, nine, and 24 hours after challenge were not related to the diurnal increase in blood eosinophils on the control day, or to the size of the late asthmatic response or accompanying changes in blood eosinophils after allergen challenge. It is concluded that serum cortisol concentrations show normal diurnal variation after allergen challenge and are unrelated to the size of the late response or associated changes in blood eosinophil counts.

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• Journal article
  de Klerk NH, Cookson WO, Musk AW, Armstrong BK, Glancy JJet al., 1989,

  Natural history of pleural thickening after exposure to crocidolite.

  , Br J Ind Med, Vol: 46, Pages: 461-467, ISSN: 0007-1072

  Serial plain chest radiographs of 384 men who worked at the Wittenoom crocidolite mine and mill between 1943 and 1966 and who applied for pneumoconiosis compensation between 1948 and 1982 have been examined independently by two trained observers for pleural disease using the 1980 ILO-UICC classification of radiographs to record width and extent of pleural disease. Radiographs covering follow up periods of from two to 38 years were examined (median number of films per subject was nine). The degree of crocidolite exposure was estimated from employment records and a survey of airborne fibre concentrations performed in 1966. Agreement between the observers on the presence and degree of pleural disease in the final film for each subject was moderately close (Kendall's tau B = 0.62) and was least for subjects with thickening less than 5 mm in width. Diffuse pleural thickening extending for greater than 50% of the lateral chest wall was the most common type recorded by both observers. Minor pleural thickening frequently progressed in extent along the lateral chest wall but progression beyond 5 mm in thickness was less common. Pleural plaques were not seen to progress beyond their initial thickness or extent. The rate of onset of thickening in this population increased continually from the time of first exposure and also increased slightly with age. There was evidence that the level of total cumulative exposure to crocidolite increased the rate of onset of pleural thickening in the period between five and 15 years after first exposure. Rate of progression of established thickening was greatest in subjects who first developed thickening early after first exposure. The relative rate of progression decreased slowly with time from first signs of thickening and there was no evidence of any progression more than 15 years after onset.

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