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Journal articleCookson WO, 1993,
Genetic aspects of atopy., Monogr Allergy, Vol: 31, Pages: 171-189, ISSN: 0077-0760
Journal articleMoffatt MF, Sharp PA, Faux JA, et al., 1992,
The results of testing for linkage between atopy and the chromosome 11 marker D11S97 is shown for all the 723 subjects genotyped by us up to January 1992. Lod score estimations were confounded by the high population prevalence of atopy, maternal inheritance of atopy at the 11q locus, genetic heterogeneity, and excess of atopy in families not ascertained through a single proband. Affected sib-pair analysis shows evidence for linkage which is not dependent on the definition of atopy or model specification. We suggest that presentation of sib-pair data will be suitable for meta-analysis of the different studies of genetic linkage and atopy.
Journal articleHUNTER GD, BAILEY CR, ARST HN, 1992,
Journal articleCook JT, Hattersley AT, Christopher P, et al., 1992,
NIDDM has a strong genetic component, as evidenced by the high level of concordance between identical twins. The nature of the genetic predisposition has remained largely unknown. Recently, the glucokinase gene locus on chromosome 7p has been shown to be linked to a subtype of NIDDM known as MODY in French and British pedigrees, and glucokinase mutations have been identified. To study the relationship between the glucokinase gene and NIDDM, we performed a linkage analysis in 12 Caucasian pedigrees ascertained through a proband with classical NIDDM. The LINKAGE program was used under four models, including autosomal dominant and recessive, with individuals with glucose intolerance counted as either affected or of unknown status. Linkage was significantly rejected with the dominant models (LOD scores -4.65, -4.25), and was unlikely with the recessive model when glucose intolerance was considered as affected (LOD score -1.38). These findings suggest that mutations in or near the glucokinase gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but do not exclude a role for this locus with a polygenic model, or a major role in some pedigrees.
Journal articleCOOKSON W, YOUNG RP, SANDFORD AJ, et al., 1992,
Journal articleMusk AW, Ryan G, James A, et al., 1992,
Factors in job decisions., J Occup Med, Vol: 34, Pages: 593-594, ISSN: 0096-1736
Journal articleYOUNG RP, SHARP PA, LYNCH JR, et al., 1992,
Journal articleDANIELS RJ, THOMAS NH, MACKINNON RN, et al., 1992,
Journal articleARST HN, 1992,
Journal articleCookson WOCM, 1992,
Erratum: Maternal inheritance of atopic IgE responsiveness on chromosomes (The Lancet (Aug 15) p 381), Lancet, Vol: 340, ISSN: 0140-6736
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