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Journal articleIto K, Adcock IM, 2002,
Histone acetylation and histone deacetylation
, Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology, Vol: 20, Pages: 99-106, ISSN: 1073-6085Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation - increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II. In contrast hypoacetylation of histones leads to tighter winding of DNA and reduced gene transcription. In this article we describe methods for measuring the histone acetyltransferase (HAT) and deacetylase (HDAC) activity of A549 cells. We initially describe methods examine whole cell HAT and HDAC activities and subsequently describe a technique for examining HAT activity associated with a specific co-activator CBP isolated by immunoprecipitation. These methods can also be applied to protein extracts from primary cells and from biopsy samples.
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Journal articleFisher MC, Koenig GL, White TJ, et al., 2002,
Molecular and phenotypic description of <i>Coccidioides Posadasii</i> sp nov., previously recognized as the non-California population of <i>Coccidioides immitis</i>
, MYCOLOGIA, Vol: 94, Pages: 73-84, ISSN: 0027-5514- Author Web Link
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- Citations: 353
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Journal articleChambers RJ, Tibballs J, Shaw AS, et al., 2002,
Picture quiz
, Imaging, Vol: 14, ISSN: 0965-6812 -
Journal articleCookson W, Moffatt M, 2002,
Immunological and genetic mechanisms of asthma
, Annales Nestle, Vol: 60, Pages: 56-65, ISSN: 0517-8606 -
Journal articleYu DFQC, Desai SR, 2002,
Lung complications in patients undergoing bone marrow transplantation
, Imaging, Vol: 14, Pages: 272-277, ISSN: 0965-6812• Pulmonary complications are common following bone marrow transplantation. • Infectious complications are the most problematic; aspergillus is the most common fungal pathogen to cause pneumonia and usually occurs in the first 100 days following transplantation. • Pulmonary oedema also occurs early in the post-transplantation period and may be cardiogenic or non-cardiogenic. • Cytomegalovirus pneumonitis tends to occur in the early phase and is associated with high mortality. • The incidence of significant Pneumocystis carinii pneumonia has decreased because of the early institution of prophylactic chemotherapy. • Constrictive obliterative bronchiolitis (a manifestation of chronic graft-versus-host disease in the lungs) can be particularly problematic; there may be severe airflow limitation leading in some patients, to respiratory failure and death. © 2002 The British Institute of Radiology.
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Journal articleDesai SR, 2002,
Acute respiratory distress syndrome: Imaging of the injured lung
, CLINICAL RADIOLOGY, Vol: 57, Pages: 8-17, ISSN: 0009-9260- Author Web Link
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- Citations: 57
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Journal articleJormakka M, Törnroth S, Abramson J, et al., 2002,
Purification and crystallization of the respiratory complex formate dehydrogenase-N from <i>Escherichia coli</i>
, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Vol: 58, Pages: 160-162, ISSN: 0907-4449- Author Web Link
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- Citations: 28
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Journal articleIto K, Adcock IM, 2002,
Histone acetylation and histone deacetylation
, MOLECULAR BIOTECHNOLOGY, Vol: 20, Pages: 99-106, ISSN: 1073-6085- Author Web Link
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- Citations: 44
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Journal articleAbecasis GR, Cherny SS, Cookson WO, et al., 2002,
Merlin-rapid analysis of dense genetic maps using sparse gene flow trees
, NATURE GENETICS, Vol: 30, Pages: 97-101, ISSN: 1061-4036- Author Web Link
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- Citations: 2743
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Conference paperJormakka M, Toernroth S, Byrne B, et al., 2002,
STRUCTURAL STUDIES ON FORMATE DEHYDROGENASE-N FROM <i>E</i>. <i>COLI</i>
, Publisher: INT UNION CRYSTALLOGRAPHY, Pages: C207-C207, ISSN: 2053-2733
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