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  • Journal article
    Cárdaba B, Moffatt MF, Fernández E, Jurado A, Rojo M, García M, Ansotegui IJ, Cortegano I, Arrieta I, Etxenagusia MA, del Pozo V, Urraca J, Aceituno E, Gallardo S, Palomino P, Cookson W, Lahoz Cet al., 2001,

    Allergy to dermatophagoides in a group of Spanish gypsies:: Genetic restrictions

    , INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol: 125, Pages: 297-306, ISSN: 1018-2438
  • Journal article
    Bidartondo MI, Ek H, Wallander H, Soderstrom Bet al., 2001,

    Do nutrient additions alter carbon sink strength of ectomycorrhizal fungi?

    , New Phytologist, Vol: 151, Pages: 543-550, ISSN: 0028-646X

    Carbon sink strength differences are examined here between ectomycorrhizal fungi in interaction with additions of ammonium and apatite (a phosphorus- and calcium-containing mineral).Pinus muricata associated with Paxillus involutus and four suilloid isolates (Suillus pungens and members of three Rhizopogon section Amylopogon species groups) were used in microcosm nutrient addition experiments.The associations differed in ectomycorrhizal biomass, mycelial growth rate, biomass and respiration. P. involutus produced the lowest biomass of ectomycorrhizal connections to P. muricata, but it consumed proportionally more carbon per connection and transferred more than twice as much ammonium to the host per unit mycorrhizal biomass. Paxillus also colonized the soil more rapidly and intensely than the other fungi, but its mycelial respiration was lowest. Ammonium and apatite addition resulted in a marked increase in respiration and mycelial biomass, respectively, by the suilloid fungi.The high carbon cost of ammonium uptake is suggested as one explanation for reduced sporocarp production and mycelial growth by ectomycorrhizal fungi commonly found after high levels of nitrogen addition.

  • Journal article
    Abecasis GR, Cherny SS, Cookson WO, Cardon LRet al., 2001,

    GRR: graphical representation of relationship errors.

    , Bioinformatics, Vol: 17, Pages: 742-743, ISSN: 1367-4803

    SUMMARY: A graphical tool for verifying assumed relationships between individuals in genetic studies is described. GRR can detect many common errors using genotypes from many markers. AVAILABILITY: GRR is available at http://bioinformatics.well.ox.ac.uk/GRR.

  • Thesis dissertation
    Georgiadis A, 2001,

    Interfacial Tension of Aqueous and Hydrocarbon Systems in the Presence of Carbon Dioxide at Elevated Pressures and Temperatures

    The interfacial tension of partially miscible phases, containing H2O andhydrocarbons in the presence of CO2 at elevated pressures and temperatures,has been studied within the context of producing cleaner fossil fuelsby simultaneously tackling greenhouse gas emissions. This is a most relevantproperty inuencing the multiphase reservoir ows associated withenhanced oil recovery (EOR), and carbon capture and storage (CCS). Themain core of the thesis focuses on the experimental investigation of thedependence of interfacial tension on pressure and temperature, for variousmixtures of pure substances relevant to oil- eld conditions and uids. Forthis purpose, a high pressure high temperature (HPHT) apparatus, comprisinga view cell, high pressure capillary tubing connections, and appropriateuid delivery syringe pumps, was used over an operating temperaturerange of (298 to 473)K and at pressures up to 60MPa. The apparatusimplemented the pendant drop method, well suited for the accuratedetermination of uid/liquid interfacial tensions at elevated pressures andtemperatures, linked to a computer-aided drop shape analysis (DSA) system.Measurements were made over a wide range of conditions for the twophasesystems (H2O+CO2), (n-decane+CO2), (n-dodecane+CO2), (n-hexadecane+CO2), (H2O+n-decane) and (H2O+[n-decane+CO2]). Thedi erent isotherms recorded for each system demonstrated systematic trendswith increasing pressure, while the decrease of interfacial tension with temperatureobserved at ambient pressures was usually reversed at elevatedpressures. For the (H2O+CO2) system in particular, the pressure dependenceof interfacial tension demonstrated abrupt changes at certain conditions,associated with the onset of the liquid or supercritical states, abovewhich the interfacial tension was less sensitive to changes in both pressureand temperature. This was not the case for the (n-alkane+CO2) systems,where the interfacial tension reduced with increasing pressure, vanishing asthe two phases be

  • Journal article
    Davies JC, Geddes DM, Alton EW, 2001,

    Prospects for gene therapy in lung disease.

    , Curr Opin Pharmacol, Vol: 1, Pages: 272-277, ISSN: 1471-4892

    The past decade has brought significant advances in the field of gene therapy for both inherited and acquired diseases, especially with regard to respiratory disease. Barriers to gene transfer posed by the lung have led to the development of modifications of both vector and host in an attempt to increase the efficiency of transfer. Recently, progress has been made in both laboratory and clinical studies of gene therapy for cystic fibrosis, alpha1-antitrypsin deficiency and lung cancer.

  • Journal article
    Abecasis GR, Cookson WO, Cardon LR, 2001,

    The power to detect linkage disequilibrium with quantitative traits in selected samples.

    , Am J Hum Genet, Vol: 68, Pages: 1463-1474, ISSN: 0002-9297

    Results from power studies for linkage detection have led to many ongoing and planned collections of phenotypically extreme nuclear families. Given the great expense of collecting these families and the imminent availability of a dense diallelic marker map, the families are likely to be used in allelic-association as well as linkage studies. However, optimal selection strategies for linkage may not be equally powerful for association. We examine the power to detect linkage disequilibrium for quantitative traits after phenotypic selection. The results encompass six selection strategies that are in widespread use, including single selection (two designs), affected sib pairs, concordant and discordant pairs, and the extreme-concordant and -discordant design. Selection of sibships on the basis of one extreme proband with high or low trait scores provides as much power as discordant sib pairs but requires the screening and phenotyping of substantially fewer initial families from which to select. Analysis of the role of allele frequencies within each selection design indicates that common trait alleles generally offer the most power, but similarities between the marker- and trait-allele frequencies are much more important than the trait-locus frequency alone. Some of the most widespread selection designs, such as single selection, yield power gains only when both the marker and quantitative trait loci (QTL) are relatively rare in the population. In contrast, discordant pairs and the extreme-proband design provide power for the broadest range of QTL-marker-allele frequency differences. Overall, proband selection from either tail provides the best balance of power, robustness, and simplicity of ascertainment for family-based association analysis.

  • Journal article
    Moffatt MF, Schou C, Faux JA, Abecasis GR, James A, Musk AW, Cookson WOCMet al., 2001,

    Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample

    , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 9, Pages: 341-346, ISSN: 1018-4813
  • Journal article
    Nagasawa T, Kudo N, Hida Y, Ito K, Ohba Yet al., 2001,

    Syntheses of chiral solid catalysts using menthol and application to the asymmetric Dials-Alder reaction

    , BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Vol: 74, Pages: 989-990, ISSN: 0009-2673
  • Journal article
    Fisher MC, Koenig GL, White TJ, San-Blas G, Negroni R, Alvarez IG, Wanke B, Taylor JWet al., 2001,

    Biogeographic range expansion into South America by <i>Coccidioides immitis</i> mirrors New World patterns of human migration

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 98, Pages: 4558-4562, ISSN: 0027-8424
  • Journal article
    Palmer LJ, Barnes KC, Burton PR, Chen H, Cookson WOCM, Deichmann KA, Elston RC, Holloway JW, Jacobs KB, Laitinen T, Wjst Met al., 2001,

    Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region

    , HUMAN MOLECULAR GENETICS, Vol: 10, Pages: 891-899, ISSN: 0964-6906

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