Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleSalgado PS, Yan R, Rowan F, et al., 2011,
Expression, crystallization and preliminary X-ray data analysis of NT-Als9-2, a fungal adhesin from <i>Candida albicans</i>
, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Vol: 67, Pages: 467-470- Author Web Link
- Cite
- Citations: 3
-
Journal articleFeary J, Britton J, Leonardi-Bee J, 2011,
Atopy and current intestinal parasite infection: a systematic review and meta-analysis
, ALLERGY, Vol: 66, Pages: 569-578, ISSN: 0105-4538- Author Web Link
- Cite
- Citations: 101
-
Conference paperBlaker JJ, Lee KY, Bismarck A, 2011,
All PLA matrix composites with anisotropic properties: Reinforcement with melt spun nanocomposite fibres of semi-crystalline PLA/bacterial cellulose nanowhiskers
, ISSN: 0065-7727 -
Conference paperLee K-Y, Blaker JJ, Bismarck A, 2011,
Why do cellulose nanofibrils behave differently when modifying freeze-dried or never-dried bacterial cellulose?
, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 -
Conference paperBlaker JJ, Lee K-Y, Bismarck A, 2011,
All PLA matrix composites with anisotropic properties: Reinforcement with melt spun nanocomposite fibres of semi-crystalline PLA/bacterial cellulose nanowhiskers
, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 -
Conference paperEichhorn SJ, Quero F, Lee K-Y, et al., 2011,
Mechanics of bacterial cellulose composite interfaces
, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 -
Conference paperWong LC, Ikem VO, Menner A, et al., 2011,
Hierarchically arranged pores in macroporous polymers synthesised using high internal phase emulsions stabilized by functionalized titania nanoparticles
, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 -
Conference paperLee K-Y, Bharadia P, Blaker JJ, et al., 2011,
Renewable hierarchical fibre reinforced bacterial cellulose nanocomposites with improved properties
, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 -
Journal articleMercado N, Thimmulappa R, Thomas CM, et al., 2011,
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
, Biochem Biophys Res Commun, Vol: 406, Pages: 292-298Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence against oxidative stress by inducing the expression of multiple anti-oxidant genes. However, where high levels of oxidative stress are observed, such as chronic obstructive pulmonary disease (COPD), Nrf2 activity is reduced, although the molecular mechanism for this defect is uncertain. Here, we show that down-regulation of histone deacetylase (HDAC) 2 causes Nrf2 instability, resulting in reduced anti-oxidant gene expression and increase sensitivity to oxidative stress. Although Nrf2 protein was clearly stabilized after hydrogen peroxide (H(2)O(2)) stimulation in a bronchial epithelial cell line (BEAS2B), Nrf2 stability was decreased and Nrf2 acetylation increased in the presence of an HDAC inhibitor, trichostatin A (TSA). TSA also reduced Nrf2-regulated heme-oxygenase-1 (HO-1) expression in these cells, and this was confirmed in acute cigarette-smoke exposed mice in vivo. HDAC2 knock-down by RNA interference resulted in reduced H(2)O(2)-induced Nrf2 protein stability and activity in BEAS2B cells, whereas HDAC1 knockdown had no effect. Furthermore, monocyte-derived macrophages obtained from healthy volunteers (non-smokers and smokers) and COPD patients showed a significant correlation between HDAC2 expression and Nrf2 expression (r=0.92, p<0.0001). Thus, reduced HDAC2 activity in COPD may account for increased Nrf2 acetylation, reduced Nrf2 stability and impaired anti oxidant defences.
-
Journal articleBidartondo MI, Read DJ, Trappe JM, et al., 2011,
The dawn of symbiosis between plants and fungi.
, Biology Letters, ISSN: 1744-957XThe colonization of land by plants relied on fundamental biological innovations, among which was symbiosis with fungi to enhance nutrient uptake. Here we present evidence that several species representing the earliest groups of land plants are symbiotic with fungi of the Mucoromycotina. This finding brings up the possibility that terrestrialization was facilitated by these fungi rather than, as conventionally proposed, by members of the Glomeromycota. Since the 1970s it has been assumed, largely from the observation that vascular plant fossils of the early Devonian (400 Ma) show arbuscule-like structures, that fungi of the Glomeromycota were the earliest to form mycorrhizas, and evolutionary trees have, until now, placed Glomeromycota as the oldest known lineage of endomycorrhizal fungi. Our observation that Endogone-like fungi are widely associated with the earliest branching land plants, and give way to glomeromycotan fungi in later lineages, raises the new hypothesis that members of the Mucoromycotina rather than the Glomeromycota enabled the establishment and growth of early land colonists.
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.
General enquiries
For any enquiries about the Fungal Science Network at Imperial, please contact: