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Journal articleIto K, Herbert C, Siegle JS, et al., 2008,
Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma
, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 543-550, ISSN: 1044-1549- Author Web Link
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- Citations: 111
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Journal articleDavies F, Faulkner L, Kearns A, et al., 2008,
NON-MENSTRUAL TOXIC SHOCK AND THE <i>IN VIVO</i> ROLES OF SEB AND IVIG
, JOURNAL OF INFECTION, Vol: 57, Pages: 426-426, ISSN: 0163-4453 -
Journal articleWeinmayr G, Forastiere F, Weiland SK, et al., 2008,
International variation in prevalence of rhinitis and its relationship with sensitisation to perennial and seasonal allergens
, EUROPEAN RESPIRATORY JOURNAL, Vol: 32, Pages: 1250-1261, ISSN: 0903-1936- Author Web Link
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- Citations: 62
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Journal articleChalmers JD, Singanayagam A, Murray MP, et al., 2008,
Prior Statin Use Is Associated with Improved Outcomes in Community-acquired Pneumonia
, AMERICAN JOURNAL OF MEDICINE, Vol: 121, Pages: 1002-U78, ISSN: 0002-9343- Author Web Link
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- Citations: 131
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PosterEllis T, Wang X, Collins JJ, 2008,
Diversity-Based Design of Synthetic Gene Networks with Desired Functions
, Synthetic Biology 4.0Constructing predictable gene networks with desired functions remains hampered by the lack of well-characterized components and the fact that assembled networks often require extensive, iterative retrofitting for optimization. Here we present an approach where network components are synthesized with random sequences incorporated into their design, giving rapid parallel production of component libraries with inherent diversity. When coupled with in silico modeling, libraries present a choice of characterized parts for gene network design, and those optimal for the desired function can be selected for network assembly, without the need for post-hoc tweaking. We validated our approach in yeast (S.cerevisiae) by synthesizing a regulatory promoter library and using it to construct negative feedforward loop networks with different, desired input-output characteristics. We then implemented the method to produce a synthetic gene network that acts as a timer, tunable by component choice. We utilize this network to control the timing of the yeast flocculation phenotype, which is crucial to brewing, illustrating a practical application of our approach.
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Journal articleSingh S, Gras A, Fiez-Vandal C, et al., 2008,
Large-scale functional expression of WT and truncated human adenosine A<sub>2A</sub> receptor in <i>Pichia pastoris</i> bioreactor cultures
, MICROBIAL CELL FACTORIES, Vol: 7, ISSN: 1475-2859- Author Web Link
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- Citations: 33
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Journal articleMoffatt MF, 2008,
Genes in asthma: new genes and new ways
, CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 8, Pages: 411-417, ISSN: 1528-4050- Author Web Link
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- Citations: 29
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Conference paperBismarck A, Brostow W, Chiu R, et al., 2008,
Effects of surface plasma treatment on tribology of thermoplastic polymers
, 15th Annual Polychar World Forum on Advanced Materials, Publisher: WILEY, Pages: 1971-1976, ISSN: 0032-3888- Author Web Link
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- Citations: 56
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Journal articleBismarck A, 2008,
Are hierarchical composite structures the way forward to improve the properties of truly green composites?
, EXPRESS POLYMER LETTERS, Vol: 2, Pages: 687-687, ISSN: 1788-618X- Author Web Link
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- Citations: 9
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Journal articleWalker SF, Bosch J, James TY, et al., 2008,
Invasive pathogens threaten species recovery programs
, CURR BIOL, Vol: 18, Pages: R853-R854, ISSN: 0960-9822
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