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Conference paperCoutts D, To Y, Ito M, et al., 2007,
Theophylline restores corticosteroid sensitivity in COPD cells via an inhibitory effect on PI3K signalling
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A28-A28, ISSN: 0040-6376 -
Conference paperHorsley AR, Aziz Z, Macleod KA, et al., 2007,
Functional and structural changes in the cystic fibrosis lung following antibiotic treatment for exacerbation
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A31-A31, ISSN: 0040-6376 -
Conference paperDavies JC, Voase N, Dewar M, et al., 2007,
Uk CF gene therapy consortium tracking study: Response of clinically available assays to intravenous antibiotics
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A30, ISSN: 0040-6376 -
Conference paperAziz ZA, Wells A, Meister M, et al., 2007,
Computed tomography in infective exacerbations in cystic fibrosis: Serial change and observer agreement
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A30-A31, ISSN: 0040-6376- Author Web Link
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- Citations: 1
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Journal articleCalcagno-Pizarelli AM, Negrete-Urtasun S, Denison SH, et al., 2007,
Establishment of the ambient pH signaling complex in <i>Aspergillus nidulans</i>:: PalI assists plasma membrane localization of PalH
, EUKARYOTIC CELL, Vol: 6, Pages: 2365-2375, ISSN: 1535-9778- Author Web Link
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- Citations: 72
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Conference paperKumar V, Charron CE, Barnes PJ, et al., 2007,
Hypoxia decreases HDAC2 in U937 cells as a possible mechanism for glucocorticoid resistance in COPD
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A27-A27, ISSN: 0040-6376 -
Journal articleHilliard TN, Regamey N, Shute JK, et al., 2007,
Airway remodelling in children with cystic fibrosis
, THORAX, Vol: 62, Pages: 1074-1080, ISSN: 0040-6376- Author Web Link
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- Citations: 109
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Journal articleBarkoulas M, Galinha C, Grigg SP, et al., 2007,
From genes to shape: regulatory interactions in leaf development
, CURRENT OPINION IN PLANT BIOLOGY, Vol: 10, Pages: 660-666, ISSN: 1369-5266- Cite
- Citations: 103
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Journal articleAdcock IM, Tsaprouni L, Bhavsar P, et al., 2007,
Epigenetic regulation of airway inflammation
, CURR OPIN IMMUNOL, Vol: 19, Pages: 694-700, ISSN: 0952-7915Diverse cellular functions including the regulation of inflammatory gene expression, DNA repair and cell proliferation are regulated by epigenetic changes. Transcriptional co-activators possess intrinsic histone acetyltransferase (HAT) activity, and histone acetylation plays a major role in inflammatory gene expression. Other marks such as histone methylation are also associated with gene induction and gene repression. Recent evidence implicates histone acetylation and methylation as being crucial for the development of tolerance in macrophages and CpG methylation for T regulatory cell development and function. The expression of the enzymes that lay down or remove these epigenetic marks have not been well studied in human airways disease, but reduced HDAC2 expression and activity is reported in lung macrophages, biopsies and blood cells from patients with COPD, severe asthma and smoking asthma. In vitro, inhibitors of histone deacetylases (HDAC) often lead to a further induction of inflammatory gene expression. This is not always the case, however, as HATs and HDACs also target non-histone proteins particularly transcription factors to alter their activity. Furthermore, trichostatin A, an HDAC inhibitor, can reduce inflammation in a murine model of allergic asthma. This effect of HDAC inhibitors may be due to their effects on cell death acting through acetylation of non-histone proteins. The role of epigenetic modifications in inflammatory gene expression and in the control of cell function in the airways is becoming clearer. Targeting specific enzymes involved in this process may lead to new therapeutic agents, in particular, in situations where current anti-inflammatory therapies are currently suboptimal.
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Journal articleGutmann DAP, Mizohata E, Newstead S, et al., 2007,
A high-throughput method for membrane protein solubility screening: The ultracentrifugation dispersity sedimentation assay (vol 16, pg 1422, 2007)
, PROTEIN SCIENCE, Vol: 16, Pages: 2775-2775, ISSN: 0961-8368
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