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  • Journal article
    Caramori G, Adcock IM, Casolari P, Ito K, Jazrawi E, Tsaprouni L, Villetti G, Civelli M, Carnini C, Chung KF, Barnes PJ, Papi Aet al., 2011,

    Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

    , THORAX, Vol: 66, Pages: 521-527, ISSN: 0040-6376
    • Cite
    • Citations: 149
  • Journal article
    Lee K-Y, Quero F, Blaker JJ, Hill CAS, Eichhorn SJ, Bismarck Aet al., 2011,

    Surface only modification of bacterial cellulose nanofibres with organic acids

    , CELLULOSE, Vol: 18, Pages: 595-605, ISSN: 0969-0239
  • Conference paper
    Freidin MB, Nicholson AG, Lim E, Moffatt MF, Cookson WOet al., 2011,

    GLOBAL GENE EXPRESSION PROFILING TO IDENTIFY COMMON NETWORKS UNDERLYING LUNG CANCER AND SPECIFIC MARKERS OF DIFFERENT LUNG CANCER HISTOLOGICAL TYPES

    , Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S455-S455, ISSN: 1556-0864
  • Conference paper
    Ege M, Mayer M, Normand A, Genuneit J, Cookson W, Braun-Fahrlander C, Heederik D, Piarroux R, von Mutius E, Gabriela Set al., 2011,

    Exposure to environmental microorganisms and its inverse relation to childhood asthma

    , 30th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 57-57, ISSN: 0105-4538
  • Conference paper
    Kotta-Loizou I, Vassilaki N, Mavromara P, 2011,

    Characterization of the translational mechanism that controls the synthesis of HCV core+1/ARF protein

    , 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Publisher: WILEY-BLACKWELL, Pages: 87-87, ISSN: 1742-464X
  • Journal article
    Katsumata Y, Kawaguchi Y, Baba S, Hattori S, Tahara K, Ito K, Iwasaki T, Yamaguchi N, Oyama M, Kozuka-Hata H, Hattori H, Nagata K, Yamanaka H, Hara Met al., 2011,

    Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches.

    , Mol Cell Proteomics, Vol: 10

    Our objective was to identify new serum autoantibodies associated with systemic lupus erythematosus (SLE), focusing on those found in patients with central nervous system (CNS) syndromes. Autoantigens in human brain proteins were screened by multiple proteomic analyses: two-dimensional polyacrylamide gel electrophoresis/Western blots followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and immunoprecipitation followed by liquid chromatography-tandem mass spectrometry shotgun analysis. The presence of serum IgG autoantibodies against 11 selected recombinant antigens was assessed by Western blot and enzyme-linked immunosorbent assay (ELISA) in the sera of 106 SLE patients and 100 normal healthy controls. The O.D. values in sera from SLE patients were significantly higher than those of controls for the antigens crystallin αB (p = 0.0002), esterase D (p = 0.0002), APEX nuclease 1 (p < 0.0001), ribosomal protein P0 (p < 0.0001), and PA28γ (p = 0.0005); the first three are newly reported. The anti-esterase D antibody levels were significantly higher in the CNS group than in the non-CNS group (p = 0.016). Moreover, when the SLE patients were categorized using CNS manifestations indicating neurologic or psychiatric disorders, the anti-APEX nuclease 1 antibody levels were significantly elevated in SLE patients with psychiatric disorders (p = 0.037). In conclusion, the association of SLE with several new and previously reported autoantibodies has been demonstrated. Statistically significant associations between anti-esterase D antibodies and CNS syndromes as well as between anti-APEX nuclease 1 antibodies and psychiatric disorders in SLE were also demonstrated. The combined immunoproteomic approaches used in this study are reliable and effective methods for identifying SLE autoantigens.
  • Journal article
    Mercado N, To Y, Ito K, Barnes PJet al., 2011,

    Nortriptyline Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ

    , JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 337, Pages: 465-470, ISSN: 0022-3565
    • Cite
    • Citations: 74
  • Journal article
    Simmonds NJ, D'Souza L, Roughton M, Alton EWFW, Davies JC, Hodson MEet al., 2011,

    Cystic fibrosis and survival to 40 years: a study of cystic fibrosis transmembrane conductance regulator function

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 37, Pages: 1076-1082, ISSN: 0903-1936
  • Journal article
    Ho KKC, Shamsuddin S-R, Laffan M, Bismarck Aet al., 2011,

    Unidirectional carbon fibre reinforced poly (vinylidene fluoride): Impact of atmospheric plasma on composite performance

    , COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, Vol: 42, Pages: 453-461, ISSN: 1359-835X
  • Journal article
    Cookson WOC, Moffatt MF, 2011,

    Genetics of complex airway disease.

    , Proc Am Thorac Soc, Vol: 8, Pages: 149-153

    The past 3 years have seen highly significant genetic effects identified for a wide variety of common complex diseases, including the airway disorders of asthma and chronic obstructive pulmonary disease. It appears that only a portion of the genetically mediated susceptibility to complex diseases has been identified, and there is much left to be discovered. This review briefly describes the results of the genome-wide association studies of asthma and gives an overview of the parallel and increasingly large-scale studies that are taking place with chronic obstructive pulmonary disease. The future impact is discussed of technological advances that allow increasingly large-scale gene expression studies, next-generation sequencing, and genome-wide testing for epigenetic effects. The use of genetic technology to examine the airway microbiota that interact with the mucosa in health and disease is described.

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