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• Conference paper
  Blanco TM, Mantalaris A, Santiapillai J, Bismarck A, Panoskaltsis Net al., 2010,

  Effects of Single-Agent, Low Dose Exogenous Erythropoietin In a Long Term In Vitro serum Free 3D Culture of Human Cord Blood Mononuclear Cells for Directed Erythropoiesis

  , Pages: 154-154, ISSN: 0006-4971
  • Cite
• Conference paper
  George PM, Mehta M, Dhariwal J, Singanayagam A, Raphael C, Salmasi M, Connell DW, Molyneaux P, Jepson A, Wickremasinghe M, Kon OMet al., 2010,

  Post bronchoscopy sputum: Increasing the diagnostic yield in smear negative pulmonary tuberculosis.

  , Winter meeting of the British Thoracic Society
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• Journal article
  Blaker JJ, Lee K-Y, Mantalaris A, Bismarck Aet al., 2010,

  Ice-microsphere templating to produce highly porous nanocomposite PLA matrix scaffolds with pores selectively lined by bacterial cellulose nano-whiskers

  , COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 70, Pages: 1879-1888, ISSN: 0266-3538
  • Author Web Link
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  • Citations: 36
• Journal article
  Singh S, Hedley D, Kara E, Gras A, Iwata S, Ruprecht J, Strange PG, Byrne Bet al., 2010,

  A purified C-terminally truncated human adenosine A_2A receptor construct is functionally stable and degradation resistant

  , PROTEIN EXPRESSION AND PURIFICATION, Vol: 74, Pages: 80-87, ISSN: 1046-5928
  • Author Web Link
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  • Citations: 21
• Journal article
  Humphreys CP, Franks PJ, Rees M, Bidartondo MI, Leake JR, Beerling DJet al., 2010,

  Mutualistic mycorrhiza-like symbiosis in the most ancient group of land plants.

  , Nature Communications, Vol: 1, ISSN: 2041-1723

  Over 35 years ago, it was hypothesized that mutualistic symbiotic soil fungi assisted land plants in their initial colonization of terrestrial environments. This important idea has become increasingly established with palaeobotanical and molecular investigations dating the interactions between arbuscular mycorrhizal fungi (AMF) and land plants to at least 400 Ma, but the functioning of analogous partnerships in 'lower' land plants remains unknown. In this study, we show with multifactorial experiments that colonization of a complex thalloid liverwort, a member of the most ancient extant clade of land plants, with AMF significantly promotes photosynthetic carbon uptake, growth and asexual reproduction. Plant fitness increased through fungal-enhanced acquisition of phosphorus and nitrogen from soil, with each plant supporting 100-400 m of AMF mycelia. A simulated CO(2)-rich atmosphere, similar to that of the Palaeozoic when land plants originated, significantly amplified the net benefits of AMF and likely selection pressures for establishment of the symbiosis. Our analyses provide essential missing functional evidence supporting AMF symbionts as drivers of plant terrestrialization in early Palaeozoic land ecosystems.

  • Abstract
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• Journal article
  Bush A, Davies J, 2010,

  Cystic fibrosis: to ion transport and beyond

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 36, Pages: 991-992, ISSN: 0903-1936
  • Author Web Link
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  • Citations: 3
• Journal article
  Davies JC, Alton EWFW, 2010,

  Gene therapy for cystic fibrosis.

  , Proc Am Thorac Soc, Vol: 7, Pages: 408-414

  The report of the first patients with cystic fibrosis (CF) to receive cystic fibrosis transmembrane conductance regulator gene (CFTR) therapy appeared in 1993, and since then there have been more than 20 clinical trials of both viral and nonviral gene transfer agents. These have largely been single dose to either nose or lower airway and have been designed around molecular or bioelectrical outcome measures. Both transgene mRNA and partial correction of chloride secretion have been reported, although sodium hyperabsorption has not been improved. The U.K. Cystic Fibrosis Gene Therapy Consortium is focused on a clinical program to establish whether these proof-of-principle measures translate into clinical benefit. Here, we review the published literature, discuss the limitations to gene therapy in the CF airway, and consider issues influencing the design of clinical trial programs.

  • Abstract
  • Author Web Link
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• Journal article
  Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Maegi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpelaeinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga J-J, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JRB, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proenca C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo M-L, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson J-O, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day INM, Dei M, Doerr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJC, Gjesing AP, Grallert H, Graessler J, Groves CJ, Guiducci C, Hartikainen A-L, Hassanali N, Havulinna AS, Herzig K-H, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki M-L, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Pare G, Parker AN, Peden JF, Pichler I, Pietilainen KH, Platou CGP, Pouta A, Ridderstrale M, Samani NJ, Saramies J, Sinisalo J Set al., 2010,

  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

  , NATURE GENETICS, Vol: 42, Pages: 949-U160, ISSN: 1061-4036
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  • Citations: 748
• Journal article
  Feary JR, Rodrigues LC, Smith CJ, Hubbard RB, Gibson JEet al., 2010,

  Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care

  , THORAX, Vol: 65, Pages: 956-962, ISSN: 0040-6376
  • Author Web Link
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  • Citations: 338
• Journal article
  Menzel R, Tran MQ, Menner A, Kay CWM, Bismarck A, Shaffer MSPet al., 2010,

  A versatile, solvent-free methodology for the functionalisation of carbon nanotubes

  , CHEMICAL SCIENCE, Vol: 1, Pages: 603-608, ISSN: 2041-6520
  • Author Web Link
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  • Citations: 36

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