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• Journal article
  Chalmers JD, Singanayagam A, Akram AR, Choudhury G, Mandal P, Hill ATet al., 2011,

  Safety and efficacy of CURB65-guided antibiotic therapy in community-acquired pneumonia

  , JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 66, Pages: 416-423, ISSN: 0305-7453
  • Author Web Link
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  • Citations: 41
• Conference paper
  Cota E, 2011,

  Als adhesins - Structural basis for the broad specificity to host-cell ligands by Candida albicans

  , Host-fungal interactions: pathogenicity versus immunity, Pages: 149-151

  Als (agglutinin-like sequence) glycoproteins have been associated with binding of host-cell surface proteins and small peptides of random sequence, the formation of biofilms and amyloid fibers. High-resolution structures of N-terminal Als domains show that ligand recognition relies on a motif capable of binding flexible C termini of peptides in extended conformation. These data establish NT-Als adhesins as a separate family of peptide-binding proteins and an unexpected adhesion system for primary, widespread protein–protein interactions at the Candida/host-cell interface. The new structural information also provides potential templates for the design of novel antifungals.

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• Journal article
  Flower B, Armstrong-James D, Dance C, Bremner F, Doherty Tet al., 2011,

  Blind, breathless, and paralysed from benign malaria

  , LANCET, Vol: 377, Pages: 438-438, ISSN: 0140-6736
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  • Citations: 8
• Journal article
  Tsaprouni LG, Ito K, Powell JJ, Adcock IM, Punchard Net al., 2011,

  Differential patterns of histone acetylation in inflammatory bowel diseases

  , Journal of Inflammation, Vol: 8, ISSN: 1078-7852
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• Journal article
  Sonoda Y, Newstead S, Hu N-J, Alguel Y, Nji E, Beis K, Yashiro S, Lee C, Leung J, Cameron AD, Byrne B, Iwata S, Drew Det al., 2011,

  Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures

  , STRUCTURE, Vol: 19, Pages: 17-25, ISSN: 0969-2126
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  • Citations: 120
• Journal article
  Bajomo M, Robb I, Steinke JHG, Bismarck Aet al., 2011,

  Fully Reversible pH-Triggered Network Formation of Amphoteric Polyelectrolyte Hydrogels

  , ADVANCED FUNCTIONAL MATERIALS, Vol: 21, Pages: 172-176, ISSN: 1616-301X
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  • Citations: 11
• Conference paper
  Bai S, Ho KKC, Knox G, Bismarck Aet al., 2011,

  Atmospheric plasma polymerisation of carbon fibres: Impact on adhesion to polyurethane elastomer

  An atmospheric plasma polymerisation (APP) rout to enhance the adhesion properties of carbon fibres to elastomeric matrix was developed. In order to examine the impact of APP of acrylonitrile precursor on carbon fibres in regards to different parameters, the surface chemistry and physical properties of the modified fibres together with micromechanical characterisation of adhesion behaviour of carbon fibre and elastomeric matrix were characterised. The surface hydrophilicity of the carbon fibres and fibre matrix compatibility were increased. The interfacial behaviour of APP modified carbon fibres and polyurethane elastomers showed significant improvement as result of the introduction of chemical functionalities to the carbon fibre surface.

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• Journal article
  Ikem VO, Menner A, Bismarck A, Norman LRet al., 2011,

  Liquid screen: Pickering emulsion templating as an effective route for forming permeable and mechanically stable void-free barriers for hydrocarbon production in subterranean formations

  , Proceedings SPE International Symposium on Oilfield Chemistry, Vol: 1, Pages: 496-504, ISSN: 1046-1779

  Gravel packs, most commonly occurring as sand slurries, are conventionally employed as a permeable solid layer in the annulus between a production screen and walls of the wellbore in weakly consolidated subterranean formations (Powell et al. 2006). Gravel packing is a well-known technique for sand control, whereby unconsolidated fines produced from the soft formation are filtered away from the production fluids (Penberthy and Shaughnessy 1992; Saucier 1974; Powell et al. 2006; Tiffin et al. 1998). Unconsolidated fines are highly challenging, as they are expensive to dispose of and can cause erosion of surface equipment, casing failure, clogging of production pipes, and production loss (Penberthy and Shaughnessy 1992; Sparlin and Hagen 1985). However, gravel packs can be problematic. Bridging of sand particles within the gravel pack can create voids, which can result in mechanical failures or significantly reduce the effectiveness of gravel packs to restrain fines from flowing along with the hydrocarbons produced (Suman 1974; Tiffin et al. 1998; Powell et al. 2006). As an alternative, this paper presents a pioneering method to prepare void-free and mechanically sound permeable barriers in subterranean formations as an alternative to gravel packing. The method of preparation involves the curing of Pickering water-in-oil medium- or high-internal-phase emulsions containing monomers in the annular space between a rock formation and pipe. The emulsions were prepared by simply adding low amounts of nonionic surfactant and dispersant to premade Pickering emulsions, which were stabilized by oleic-acid (OA) modified silica particles (Ikem et al. 2008). The resulting solid materials, known as "poly-Pickering-M/HIPE," have a gas permeability of up to 2.6 darcies and are highly interconnected and permeable to hydrocarbons (Ikem et al. 2010b). This paper shows that it is possible to tailor the gas permeability and mechanical performance of the permeable barrier by alter

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  • Citations: 2
• Journal article
  Kot E, Bismarck A, Saini RK, Norman LRet al., 2011,

  Novel drag-reducing agents for fracturing treatments based on polyacrylamide containing weak labile links in the polymer backbone

  , Proceedings SPE International Symposium on Oilfield Chemistry, Vol: 2, Pages: 505-515, ISSN: 1046-1779

  Water-soluble polymers have found extensive use in the oil and gas industry. For instance, high molecular-weight polymers are very efficient drag/friction-reducing agents and viscosifiers. Unfortunately, the adsorption of the polymer on the reservoir formation reduces the effectiveness of the recovery of oil and gas from tight low-permeability formations, such as shale. The availability of water-soluble polymers containing weak links in the backbone of the polymer that can be degraded upon experiencing a certain trigger, such as temperature, pH, or reducing agent, would be very advantageous. Because of the ability of weak links to degrade under certain conditions, such polymers can be used for their intended application and afterwards be degraded in a controlled and predetermined way. The resulting lower molecular-weight fractions of that polymer lead to reduced viscosity, quick partitioning in the water phase, and they are also less likely to adsorb onto formation surfaces. Additionally, no oxidizers need to be pumped to break or clean the deposited polymer, thus, saving time and money. It has been proved that using a bifunctional reducing agent containing degradable groups and oxidizing metal ion as a redox couple is a facile method to initiate the free-radical polymerisation and build degradable groups into the backbone of the vinyl polymers. Temperature-degradable but hydrolytically stable azo groups showed the most desirable results. The presence of azo groups in the backbone of the synthesized Polyacrylamide (PAM) was confirmed by H¹-NMR spectra and differential scanning calorimetry (DSC). The degradation behavior of the PAM with temperature-sensitive azo groups was characterised using gel permeation chromatography (GPC) system and proved the multiple labile links were built into the polymer backbone. It was also found that PAM with azo links in the polymer backbone is as good a drag-reducing agent as pure PAM. However, PAM with azo link

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  • Citations: 1
• Journal article
  El Mouden EH, Slimani T, Donaire D, Fernández-Beaskoetxea S, Fisher MC, Bosch Jet al., 2011,

  First record of the chytrid fungus Batrachochytrium dendrobatidis in North Africa

  , Herpetological Review, Vol: 42, Pages: 71-75, ISSN: 0018-084X
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  • Citations: 24

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