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Journal articleUsmani OS, Ito K, Maneechotesuwan K, et al., 2005,
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 704-712, ISSN: 1073-449X- Author Web Link
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- Citations: 166
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Conference paperMoffatt MF, Allen MH, Reynolds NJ, et al., 2005,
A case-control study investigating candidate genes in adult eczema
, 35th Annual Meeting of the European-Society-for-Dermatological-Research, Publisher: BLACKWELL PUBLISHING, Pages: A22-A22, ISSN: 0022-202X -
Conference paperMorar N, Bowcock AM, Harper J, et al., 2005,
Investigation of the chromosome 17q25 <i>PSORS2</i> locus in atopic dermatitis
, 35th Annual Meeting of the European-Society-for-Dermatological-Research, Publisher: BLACKWELL PUBLISHING, Pages: A25-A25, ISSN: 0022-202X -
Journal articleAbou Neel EA, Ahmed I, Blaker JJ, et al., 2005,
Effect of iron on the surface, degradation and ion release properties of phosphate-based glass fibres
, ACTA BIOMATERIALIA, Vol: 1, Pages: 553-563, ISSN: 1742-7061- Author Web Link
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- Citations: 108
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Journal articleSpencer H, Kozlowska W, Davies JC, et al., 2005,
Measurement of tobramycin and gentamicin in saliva is not suitable for therapeutic drug monitoring of patients with cystic fibrosis.
, J Cyst Fibros, Vol: 4, ISSN: 1569-1993 -
Journal articleHerranz S, Rodríguez JM, Bussink HJ, et al., 2005,
Arrestin-related proteins mediate pH signaling in fungi
, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 12141-12146, ISSN: 0027-8424- Author Web Link
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- Citations: 117
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Journal articleBarnes PJ, Adcock IM, Ito K, 2005,
Histone deacetylase activity and COPD - Reply
, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 353, Pages: 528-529, ISSN: 0028-4793 -
Journal articleJames ES, Harney S, Wordsworth BP, et al., 2005,
PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders.
, Genes Immun, Vol: 6, Pages: 430-437, ISSN: 1466-4879Variation in genes encoding costimulatory molecules expressed on lymphocytes has been expected to contribute to the genetic component of inflammatory disease, but only the gene encoding the inhibitory protein, CTLA-4, seems consistently to confer disease susceptibility. Studies in murine models implicate the inhibitory product of the pd1 gene, programmed death-1, in the maintenance of peripheral tolerance to self-antigens. We identify 22 single-nucleotide polymorphisms (SNPs) in the equivalent human gene, PDCD1, a number of which show significant associations with the specific immunoglobulin E response to grass allergens in atopic individuals. Stepwise analyses indicate that four of the disease-associated SNPs have independent effects. The two most common haplotypes show positive and negative associations but rarer haplotypes are also likely to be of influence. In a case-control study, multiple regression analysis of genotypic data implies that PDCD1 also confers susceptibility to rheumatoid arthritis. Along with work linking PDCD1 with susceptibility to another autoimmune condition, systemic lupus erythematosus, our data identify PDCD1 as a second immunomodulatory gene with pleiotropic effects in human disease. Genes encoding negative regulators may generally confer a significant fraction of the genetic risk associated with inherited inflammatory disorders.
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Journal articleBignell E, Negrete-Urtasun S, Calcagno AM, et al., 2005,
Virulence comparisons of <i>Aspergillus nidulans</i> mutants are confounded by the inflammatory response of p47<SUP><i>phox</i>-/-</SUP> mice
, INFECTION AND IMMUNITY, Vol: 73, Pages: 5204-5207, ISSN: 0019-9567- Author Web Link
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- Citations: 24
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Journal articleBismarck A, Lee AF, Saraç AS, et al., 2005,
Electrocoating of carbon fibres:: A route for interface control in carbon fibre reinforced poly methylmethacrylate?
, COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 65, Pages: 1564-1573, ISSN: 0266-3538- Author Web Link
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- Citations: 24
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