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• Journal article
  Singanayagam A, Chalmers JD, Hill AT, 2010,

  Inhaled corticosteroids and risk of pneumonia: evidence for and against the proposed association

  , QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 103, Pages: 379-385, ISSN: 1460-2725
  • Author Web Link
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  • Citations: 23
• Conference paper
  Jayasena AS, Meng Y, Bindschedler L, Spanu P, Wise R, Bogdanove Aet al., 2010,

  <i>Xanthomonas</i> type III secretion system based analysis of candidate effectors from <i>Blumeria graminis</i> f. sp <i>hordei</i>

  , Annual Meeting of the American-Phytopathological-Society (APS), Publisher: AMER PHYTOPATHOLOGICAL SOC, Pages: S56-S56, ISSN: 0031-949X
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• Journal article
  Chotirmall SH, Flynn MG, Donegan CF, Smith D, O'Neill SJ, McElvaney NGet al., 2010,

  Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and legal perspectives

  , JOURNAL OF CRITICAL CARE, Vol: 25, ISSN: 0883-9441
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• Journal article
  Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier M-H, Duffy DL, Evans DM, Ferreira MAR, Kere J, Laitinen T, Malerba G, Meyers DA, Moffatt M, Martin NG, Ng MY, Pignatti PF, Wjst M, Kauffmann F, Demenais F, Lewis CMet al., 2010,

  Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.

  , Eur J Hum Genet, Vol: 18, Pages: 700-706

  Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (>or=3024 families with >or=10 027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21-p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3-q24 in all families for SPT and three other regions in European families (2q32-q34 for EOS, 5q23-q33 for SPTQ and 17q12-q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11-3q21, whereas between-study heterogeneity was detected for asthma in 2p22-p13 and 6p21, and for atopic asthma in 1q23-q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.

  • Abstract
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• Journal article
  Hsu Y-H, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, Hofman A, van Meurs JB, Pols HAP, Price RI, Nilsson O, Pastinen T, Cupples LA, Lusis AJ, Schadt EE, Ferrari S, Uitterlinden AG, Rivadeneira F, Spector TD, Karasik D, Kiel DPet al., 2010,

  An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

  , PLOS GENETICS, Vol: 6, ISSN: 1553-7404
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  • Citations: 156
• Journal article
  Barrett NA, Armstrong-James D, Edgeworth J, Wyncoll Det al., 2010,

  Novel H1N1 influenza and Panton-Valentine leukocidin <i>Staphylococcus aureus</i> necrotizing pneumonia

  , BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 71, Pages: 350-351, ISSN: 1750-8460
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  • Citations: 4
• Journal article
  Wu R, Menner A, Bismarck A, 2010,

  Tough Interconnected Polymerized Medium and High Internal Phase Emulsions Reinforced by Silica Particles

  , JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, Vol: 48, Pages: 1979-1989, ISSN: 0887-624X
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  • Citations: 61
• Journal article
  Armstrong-James D, Stebbing J, Scourfield A, Smit E, Ferns B, Pillay D, Nelson Met al., 2010,

  Clinical outcome in resistant HIV-2 infection treated with raltegravir and maraviroc

  , ANTIVIRAL RESEARCH, Vol: 86, Pages: 224-226, ISSN: 0166-3542
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  • Citations: 35
• Journal article
  Lin Y-M, Zhang A, Rippon HJ, Bismarck A, Bishop AEet al., 2010,

  Tissue Engineering of Lung: The Effect of Extracellular Matrix on the Differentiation of Embryonic Stem Cells to Pneumocytes

  , TISSUE ENGINEERING PART A, Vol: 16, Pages: 1515-1526, ISSN: 1937-3341
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  • Citations: 56
• Journal article
  Rahman NM, Singanayagam A, Davies HE, Wrightson JM, Mishra EK, Lee YCG, Benamore R, Davies RJO, Gleeson FVet al., 2010,

  Diagnostic accuracy, safety and utilisation of respiratory physician-delivered thoracic ultrasound

  , THORAX, Vol: 65, Pages: 449-453, ISSN: 0040-6376
  • Author Web Link
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  • Citations: 56

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