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• Journal article
  Martino E, Murat C, Vallino M, Bena A, Perotto S, Spanu Pet al., 2007,

  Imaging mycorrhizal fungal transformants that express EGFP during ericoid endosymbiosis

  , CURRENT GENETICS, Vol: 52, Pages: 65-75, ISSN: 0172-8083
  • Author Web Link
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  • Citations: 26
• Journal article
  Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SAG, Wong KCC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WOCet al., 2007,

  Genetic variants regulating <i>ORMDL3</i> expression contribute to the risk of childhood asthma

  , NATURE, Vol: 448, Pages: 470-U5, ISSN: 0028-0836
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  • Citations: 1270
• Journal article
  Bajomo M, Steinke JHG, Bismarck A, 2007,

  Inducing pH responsiveness via ultralow thiol content in polyacrylamide (Micro)Gels with labile crosslinks

  , JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 111, Pages: 8655-8662, ISSN: 1520-6106
  • Author Web Link
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  • Citations: 18
• Conference paper
  Morar N, Edster P, Street T, Weidinger S, Di W-L, Dixon A, Taylor M, Holt R, Broxholme J, Kloop N, Novak N, Bockelbrinck A, Ragoussis J, Illig T, Harper J, Cookson W, Moffatt Met al., 2007,

  Fine mapping of susceptibility genes for atopic dermatitis in the epidermal differentiation complex on chromosome 1q21

  , 87th Annual Meeting of the British-Association-of-Dermatologists, Publisher: BLACKWELL PUBLISHING, Pages: 3-3, ISSN: 0007-0963
  • Author Web Link
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  • Citations: 3
• Journal article
  Gutmann DAP, Mizohata E, Newstead S, Ferrandon S, Henderson PJF, Van Veen HW, Byrne Bet al., 2007,

  A high-throughput method for membrane protein solubility screening: The ultracentrifugation dispersity sedimentation assay

  , PROTEIN SCIENCE, Vol: 16, Pages: 1422-1428, ISSN: 0961-8368
  • Author Web Link
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  • Citations: 52
• Journal article
  Bush A, Davies J, 2007,

  Response to mallory: You are civilized, but still wrong, Dr. Mallory

  , PEDIATRIC PULMONOLOGY, Vol: 42, Pages: 658-658, ISSN: 8755-6863
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  • Citations: 2
• Journal article
  Morar N, Cookson WOCM, Harper JI, Moffatt MFet al., 2007,

  Filaggrin mutations in children with severe atopic dermatitis

  , JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 127, Pages: 1667-1672, ISSN: 0022-202X
  • Author Web Link
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  • Citations: 161
• Journal article
  Ellis T, Evans DA, Martin CRH, Hartley JAet al., 2007,

  A 96-well DNase I footprinting screen for drug-DNA interactions

  , Nucleic Acids Research, Vol: 35, Pages: 1-8, ISSN: 0305-1048

  The established protocol for DNase I footprinting has been modified to allow multiple parallel reactions to be rapidly performed in 96-well microtitre plates. By scrutinizing every aspect of the traditional method and making appropriate modifications it has been possible to considerably reduce the time, risk of sample loss and complexity of footprinting, whilst dramatically increasing the yield of data (30-fold). A semi-automated analysis system has also been developed to present footprinting data as an estimate of the binding affinity of each tested compound to any base pair in the assessed DNA sequence, giving an intuitive ‘one compound–one line’ scheme. Here, we demonstrate the screening capabilities of the 96-well assay and the subsequent data analysis using a series of six pyrrolobenzodiazepine-polypyrrole compounds and human Topoisomerase II alpha promoter DNA. The dramatic increase in throughput, quantified data and decreased handling time allow, for the first time, DNase I footprinting to be used as a screening tool to assess DNA-binding agents.

  • Abstract
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• Journal article
  Marwick JA, Ito K, Adcock IM, Kirkham PAet al., 2007,

  Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

  , EXPERT OPINION ON THERAPEUTIC TARGETS, Vol: 11, Pages: 745-755, ISSN: 1472-8222
  • Author Web Link
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  • Citations: 59
• Journal article
  Davies JC, Rubin BK, 2007,

  Emerging and unusual gram-negative infections in cystic fibrosis

  , SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 28, Pages: 312-321, ISSN: 1069-3424
  • Author Web Link
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  • Citations: 68

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