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• Journal article
  James ES, Harney S, Wordsworth BP, Cookson WOCM, Davis SJ, Moffatt MFet al., 2005,

  PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders.

  , Genes Immun, Vol: 6, Pages: 430-437, ISSN: 1466-4879

  Variation in genes encoding costimulatory molecules expressed on lymphocytes has been expected to contribute to the genetic component of inflammatory disease, but only the gene encoding the inhibitory protein, CTLA-4, seems consistently to confer disease susceptibility. Studies in murine models implicate the inhibitory product of the pd1 gene, programmed death-1, in the maintenance of peripheral tolerance to self-antigens. We identify 22 single-nucleotide polymorphisms (SNPs) in the equivalent human gene, PDCD1, a number of which show significant associations with the specific immunoglobulin E response to grass allergens in atopic individuals. Stepwise analyses indicate that four of the disease-associated SNPs have independent effects. The two most common haplotypes show positive and negative associations but rarer haplotypes are also likely to be of influence. In a case-control study, multiple regression analysis of genotypic data implies that PDCD1 also confers susceptibility to rheumatoid arthritis. Along with work linking PDCD1 with susceptibility to another autoimmune condition, systemic lupus erythematosus, our data identify PDCD1 as a second immunomodulatory gene with pleiotropic effects in human disease. Genes encoding negative regulators may generally confer a significant fraction of the genetic risk associated with inherited inflammatory disorders.

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• Conference paper
  Maeda K, Bismarck A, Briscoe BJ, 2005,

  Mechanisms of scratching frictions and damage maps for rubber compounds

  , 15th International Conference on Wear of Materials, Publisher: ELSEVIER SCIENCE SA, Pages: 651-660, ISSN: 0043-1648
  • Cite
  • Citations: 26
• Journal article
  Both M, Csukai M, Stumpf MPH, Spanu PDet al., 2005,

  Gene expression profiles of <i>Blumeria graminis</i> indicate dynamic changes to primary metabolism during development of an obligate biotrophic pathogen

  , PLANT CELL, Vol: 17, Pages: 2107-2122, ISSN: 1040-4651
  • Cite
  • Citations: 126
• Journal article
  Bismarck A, Pfaffernoschke M, Springer J, Schulz Eet al., 2005,

  Polystyrene-grafted carbon fibers: Surface properties and adhesion to polystyrene

  , JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS, Vol: 18, Pages: 307-331, ISSN: 0892-7057
  • Author Web Link
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  • Citations: 12
• Journal article
  Brindicci C, Ito K, Resta O, Pride NB, Barnes PJ, Kharitonov SAet al., 2005,

  Exhaled nitric oxide from lung periphery is increased in COPD

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 26, Pages: 52-59, ISSN: 0903-1936
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  • Citations: 167
• Journal article
  Wada H, Kagoshima M, Ito K, Barnes PJ, Adcock IMet al., 2005,

  5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene

  , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 331, Pages: 93-99, ISSN: 0006-291X
  • Author Web Link
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  • Citations: 15
• Journal article
  McGovern DPB, Hysi P, Ahmad T, van Heel DA, Moffatt MF, Carey A, Cookson WOC, Jewell DPet al., 2005,

  Association between a complex insertion/deletion polymorphism in <i>NOD1</i> (<i>CARD4</i>) and susceptibility to inflammatory bowel disease

  , HUMAN MOLECULAR GENETICS, Vol: 14, Pages: 1245-1250, ISSN: 0964-6906
  • Author Web Link
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  • Citations: 253
• Journal article
  Moffatt M, Hysi P, Cookson W, 2005,

  Haplotypes and asthma

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 1066-1067, ISSN: 1073-449X
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• Journal article
  Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC, Barnes PJet al., 2005,

  Decreased histone deacetylase activity in chronic obstructive pulmonary disease

  , NEW ENGLAND JOURNAL OF MEDICINE, Vol: 352, Pages: 1967-1976, ISSN: 0028-4793
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  • Citations: 722
• Journal article
  Davies JC, Davies M, McShane D, Smith S, Chadwick S, Jaffe A, Farley R, Collins L, Bush A, Scallon M, Pepper J, Geddes DM, Alton EWFWet al., 2005,

  Potential difference measurements in the lower airway of children with and without cystic fibrosis

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 1015-1019, ISSN: 1073-449X
  • Cite
  • Citations: 30

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