Publications

Search or filter publications

Search publications Search

Filter by type:

Filter by publication type

• Book
• Book chapter
• Conference paper
• Journal article
• Other
• Patent
• Poster
• Report
• Scholarly edition
• Software
• Thesis dissertation
• Working paper

Filter by year:

Filter from 2025202420232022202120202019201820172016201520142013201220112010200920082007200620052004200320022001200019991998199719961995199419931992199119901989198819871986198519841983198219811980197919781977197619751974197319721971197019691968 to Filter to 2025202420232022202120202019201820172016201520142013201220112010200920082007200620052004200320022001200019991998199719961995199419931992199119901989198819871986198519841983198219811980197919781977197619751974197319721971197019691968

---

Search results

• Journal article
  Taylor JW, Jacobson DJ, Kroken S, Kasuga T, Geiser DM, Hibbett DS, Fisher MCet al., 2000,

  Phylogenetic species recognition and species concepts in fungi

  , FUNGAL GENETICS AND BIOLOGY, Vol: 31, Pages: 21-32, ISSN: 1087-1845
  • Author Web Link
  • Cite
  • Citations: 1390
• Journal article
  Lonjou C, Barnes K, Chen H, Cookson WOCM, Deichmann KA, Hall IP, Holloway JW, Laitinen T, Palmer LJ, Wjst M, Morton NEet al., 2000,

  A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG)

  , Proceedings of the National Academy of Sciences of the United States of America, Vol: 97, Pages: 10942-10947, ISSN: 0027-8424

  The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in several ways. Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds (lod) = 2.61 near IL-4], but no evidence for atopy. The principal problems with retrospective collaboration on linkage appear to have been solved, providing far more information than a single study. A multipoint lod table evaluated at commonly agreed reference loci is required for both collaboration and metaanalysis, but variations in ascertainment, pedigree structure, phenotype definition, and marker selection are tolerated. These methods are invariant with statistical methods that increase the power of lods and are applicable to all diseases, motivating collaboration rather than competition. In contrast to linkage, positional cloning by allelic association has yet to be extended to multiple samples, a prerequisite for efficient combination with linkage and the greatest current challenge to genetic epidemiology.

  • Abstract
  • Cite
  • Citations: 38
• Journal article
  Cota E, Hamill SJ, Fowler SB, Clarke Jet al., 2000,

  Two proteins with the same structure respond very differently to mutation: The role of plasticity in protein stability

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 302, Pages: 713-725, ISSN: 0022-2836
  • Author Web Link
  • Cite
  • Citations: 66
• Journal article
  Palmer LJ, Cookson WO, 2000,

  Genomic approaches to understanding asthma.

  , Genome Res, Vol: 10, Pages: 1280-1287, ISSN: 1088-9051

  Asthma is the most common chronic childhood disease in developed nations, and it is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. The genetic aetiology of asthma offers a means of better understanding its pathogenesis and, thus, improving preventive strategies, diagnostic tools, and therapies. Considerable effort and expense have been expended in attempts to detect genetic loci contributing to asthma susceptibility, and extensive candidate gene studies and a number of whole-genome screens have been undertaken. This article reviews the current state of knowledge of the genetics of asthma, with a focus on genomic approaches to understanding allergic diseases.

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Ito K, Barnes PJ, Adcock IM, 2000,

  Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12

  , MOLECULAR AND CELLULAR BIOLOGY, Vol: 20, Pages: 6891-6903, ISSN: 0270-7306
  • Author Web Link
  • Cite
  • Citations: 543
• Journal article
  Byrne B, Abramson J, Jansson M, Holmgren E, Iwata Set al., 2000,

  Fusion protein approach to improve the crystal quality of cytochrome <i>bo</i>₃ ubiquinol oxidase from <i>Escherichia coli</i>

  , BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1459, Pages: 449-455, ISSN: 0005-2728
  • Author Web Link
  • Cite
  • Citations: 9
• Journal article
  Abramson J, Larsson G, Byrne B, Puustinen A, Garcia-Horsman A, Iwata Set al., 2000,

  Purification, crystallization and preliminary crystallographic studies of an integral membrane protein, cytochrome <i>bo</i>₃ ubiquinol oxidase from <i>Escherichia coli</i>

  , ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, Vol: 56, Pages: 1076-1078, ISSN: 2059-7983
  • Author Web Link
  • Cite
  • Citations: 11
• Journal article
  Fisher MC, Koenig G, White TJ, Taylor JWet al., 2000,

  A test for concordance between the multilocus genealogies of genes and microsatellites in the pathogenic fungus <i>Coccidioides immitis</i>

  , MOLECULAR BIOLOGY AND EVOLUTION, Vol: 17, Pages: 1164-1174, ISSN: 0737-4038
  • Author Web Link
  • Cite
  • Citations: 75
• Journal article
  Abecasis GR, Cookson WO, Cardon LR, 2000,

  Pedigree tests of transmission disequilibrium.

  , Eur J Hum Genet, Vol: 8, Pages: 545-551, ISSN: 1018-4813

  High-resolution mapping is essential for the positional cloning of complex disease genes. In outbred populations, linkage disequilibrium is expected to extend for short distances and could provide a powerful fine-mapping tool. Current family-based association tests use nuclear family members to define allelic transmission and controls, but ignore other types of relatives. Here we construct a general approach for scoring allelic transmission that accommodates families of any size and uses all available genotypic information. Family data allows for the construction of an expected genotype for every non-founder, and orthogonal deviates from this expectation are a measure of allelic transmission. These allelic transmission scores can be used to extend previously described tests of linkage disequilibrium for dichotomous or quantitative traits. Some of these tests are illustrated, together with a permutation framework for estimating exact significance levels. Simulation studies are used to investigate power and error rates of the approach. As a practical application, the method is used to investigate the relationship between circulating angiotensin-1 converting enzyme (ACE) levels and polymorphisms in the ACE gene using previously published data.

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Brown JS, Aufauvre-Brown A, Brown J, Jennings JM, Arst H, Holden DWet al., 2000,

  Signature-tagged and directed mutagenesis identify PABA synthetase as essential for <i>Aspergillus fumigatus</i> pathogenicity

  , MOLECULAR MICROBIOLOGY, Vol: 36, Pages: 1371-1380, ISSN: 0950-382X
  • Author Web Link
  • Cite
  • Citations: 111

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.