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  • Journal article
    Espeso EA, Roncal T, Díez E, Rainbow L, Bignell E, Alvaro J, Suárez T, Denison SH, Tilburn J, Arst HN, Peñalva MAet al., 2000,

    On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction

    , EMBO JOURNAL, Vol: 19, Pages: 719-728, ISSN: 0261-4189
  • Journal article
    Arst HN, 2000,

    Apathy rewards misconduct - and everybody suffers

    , NATURE, Vol: 403, Pages: 478-478, ISSN: 0028-0836
  • Journal article
    Chaure P, Gurr SJ, Spanu P, 2000,

    Stable transformation of <i>Erysiphe graminis</i>, an obligate biotrophic pathogen of barley

    , NATURE BIOTECHNOLOGY, Vol: 18, Pages: 205-207, ISSN: 1087-0156
  • Journal article
    Fisher MC, Koenig GL, White TJ, Taylor JWet al., 2000,

    Pathogenic clones versus environmentally driven population increase:: Analysis of an epidemic of the human fungal pathogen <i>Coccidioides immitis</i>

    , JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 38, Pages: 807-813, ISSN: 0095-1137
  • Journal article
    Abecasis GR, Cookson WO, 2000,

    GOLD--graphical overview of linkage disequilibrium.

    , Bioinformatics, Vol: 16, Pages: 182-183, ISSN: 1367-4803

    SUMMARY: We describe a software package that provides a graphical summary of linkage disequilibrium in human genetic data. It allows for the analysis of family data and is well suited to the analysis of dense genetic maps. AVAILABILITY: http://www.well.ox.ac.uk/asthma/GOLD CONTACT: goncalo@well.ox.ac.uk
  • Journal article
    Paterson S, Fisher MC, Viney ME, 2000,

    Inferring infection processes of a parasitic nematode using population genetics

    , PARASITOLOGY, Vol: 120, Pages: 185-194, ISSN: 0031-1820
  • Journal article
    Marshall RP, Puddicombe A, Cookson WO, Laurent GJet al., 2000,

    Adult familial cryptogenic fibrosing alveolitis in the United Kingdom.

    , Thorax, Vol: 55, Pages: 143-146, ISSN: 0040-6376

    BACKGROUND: Familial cases of cryptogenic fibrosing alveolitis (CFA) have previously been reported; however, the prevalence and genetic background of this disorder are not known. The clinical and epidemiological findings of 25 families identified within the UK are reported. METHODS: Adult pulmonary physicians in the UK were asked to identify all families under their care in which two or more individuals had been diagnosed with fibrosing alveolitis of unknown cause. A detailed structured questionnaire was sent to each proband to delineate possible environmental/occupational exposures and to obtain complete pedigree data. Physicians were also asked to provide clinical and diagnostic information. RESULTS: Twenty five families were identified comprising 67 cases. Suitable data for analysis were available for 21 families (57 cases). The male:female ratio was 1. 75:1 (p<0.05). A high resolution computed tomographic (HRCT) scan was performed in 93% and a diagnosis of CFA confirmed on biopsy specimens in 32%. The mean age at diagnosis was 55.5 (2.5) years. Fifty percent of cases were ever smokers and 18% had been diagnosed as asthmatic. Exposure to known fibrogenic agents was recorded by 36% of patients. Clinical signs/symptoms and histological findings were indistinguishable from non-familial cases. CONCLUSIONS: This study represents the largest cohort of familial CFA cases reported to date and confirms a prevalence of 1.34 cases per 10(6) in the UK population. Although rare, such cases represent an important subgroup in which a genetic susceptibility to pulmonary fibrosis is particularly evident. Familial patients are younger at diagnosis but otherwise indistinguishable from non-familial cases. The mode of inheritance is as yet unclear but a number of genetic loci are likely to be involved and are the subject of ongoing studies.
  • Journal article
    Hamill SJ, Cota E, Chothia C, Clarke Jet al., 2000,

    Conservation of folding and stability within a protein family: The tyrosine corner as an evolutionary cul-de-sac

    , JOURNAL OF MOLECULAR BIOLOGY, Vol: 295, Pages: 641-649, ISSN: 0022-2836
  • Journal article
    Greene DR, Koenig G, Fisher MC, Taylor JWet al., 2000,

    Soil isolation and molecular identification of <i>Coccidioides immitis</i>

    , MYCOLOGIA, Vol: 92, Pages: 406-410, ISSN: 0027-5514
  • Journal article
    Sanderson E, Desai SR, 2000,

    Non-vascular thoracic intervention

    , Imaging, Vol: 12, Pages: 178-192, ISSN: 0965-6812

    · Radiologically guided percutaneous needle biopsy is a safe and well tolerated procedure, which can often be performed as an outpatient procedure. · Transthoracic needle biopsy is most effective in the diagnosis of malignancy, but has limitations since the likelihood of obtaining a specific benign diagnosis is often low. · Percutaneous image-guided aspiration and drainage are fast becoming the ″first line″ treatments for the management of pleural and mediastinal collections; percutaneous drainage of lung abscess is an acceptable alternative to surgery where medical therapy has failed. · Tracheobronchial stenting is a valuable (often palliative) technique in the management of airway narrowing.

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