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• Journal article
  Tanabe M, Atkins HS, Harland DN, Elvin SJ, Stagg AJ, Mirza O, Titball RW, Byrne B, Brown KAet al., 2006,

  The ABC transporter protein OppA provides protection against experimental <i>Yersinia pestis</i> infection

  , INFECTION AND IMMUNITY, Vol: 74, Pages: 3687-3691, ISSN: 0019-9567
  • Author Web Link
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  • Citations: 58
• Journal article
  Adcock IM, Caramori G, Ito K, 2006,

  New insights into the molecular mechanisms of corticosteroids actions

  , CURRENT DRUG TARGETS, Vol: 7, Pages: 649-660, ISSN: 1389-4501
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  • Citations: 33
• Journal article
  Higuchi T, Reed A, Oto T, Holsworth L, Ellis S, Bailey MJ, Williams TJ, Snell GIet al., 2006,

  Relation of interlobar collaterals to radiological heterogeneity in severe emphysema.

  , Thorax, Vol: 61, Pages: 409-413, ISSN: 0040-6376

  BACKGROUND: A study was undertaken to assess the prevalence of interlobar collateral ventilation in patients with severe emphysema to identify factors that may help to predict patients with significant collateral ventilation. METHODS: Between April 2002 and August 2003, ex vivo assessment of the lungs 17 consecutive patients with smoking related severe emphysema was performed. To assess collateral flow, all lobes of explanted specimens were selectively intubated using a wedged cuffed microlaryngeal intubation tube and then manually ventilated using a bagging circuit. Interlobar collateral ventilation was defined as the ability to easily inflate a non-intubated lobe at physiological pressures. Pre-transplant demographic characteristics, physiological data, radiological results, and explant histology were assessed for retrospective relationships with the degree of interlobar collateral ventilation in the explanted lung. RESULTS: A total of 23 lungs were evaluated, 15 of which (66%) had significant collateral interlobar airflow. There were no significant differences in any demographic, physiological, or pathological variables between patients with collateral ventilation and those with no collateral ventilation. However, there was a significant relationship between the presence of interlobar collateral ventilation and radiological scores (p<0.05). CONCLUSIONS: Interlobar collateral ventilation occurs to a much greater extent in patients with radiologically homogeneous emphysema than in those with heterogeneous emphysema. Heterogeneity of emphysema may predict patients with a significantly reduced risk of interlobar collateral ventilation.

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• Journal article
  Menner A, Powell R, Bismarck A, 2006,

  A new route to carbon black filled polyHIPEs

  , SOFT MATTER, Vol: 2, Pages: 337-342, ISSN: 1744-683X
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  • Citations: 62
• Conference paper
  Lamoriniere S, Greenhalgh E, Shaffer M, Bismarck Aet al., 2006,

  On Route to Hierarchical Composites

  , PolyCHAR-14 World Forum of Advanced Materials
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• Journal article
  Fujitani Y, Nakajima N, Ishihara K, Oikawa T, Ito K, Sugimoto Met al., 2006,

  Molecular and biochemical characterization of a serine racemase from Arabidopsis thaliana.

  , Phytochemistry, Vol: 67, Pages: 668-674, ISSN: 0031-9422

  A cDNA encoding a homolog of mammalian serine racemase, a unique enzyme in eukaryotes, was isolated from Arabidopsis thaliana and expressed in Escherichia coli cells. The gene product, of which the amino acid residues for binding pyridoxal 5'-phosphate (PLP) are conserved in this as well as mammalian serine racemases, catalyzes not only serine racemization but also dehydration of serine to pyruvate. The enzyme is a homodimer and requires PLP and divalent cations, Ca2+, Mg2+, Mn2+, Fe2+, or Ni2+, at alkaline pH for both activities. The racemization process is highly specific toward L-serine, whereas L-alanine, L-arginine, and L-glutamine were poor substrates. The Vmax/Km values for racemase activity of L- and D-serine are 2.0 and 1.4 nmol/mg/min/mM, respectively, and those values for L- and D-serine on dehydratase activity are 13 and 5.3 nmol/mg/min/mM, i.e. consistent with the theory of racemization reaction and the specificity of dehydration toward L-serine. Hybridization analysis showed that the serine racemase gene was expressed in various organs of A. thaliana.

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• Journal article
  Equi AC, Davies JC, Painter H, Hyde S, Bush A, Geddes DM, Alton EWFWet al., 2006,

  Exploring the mechanisms of macrolides in cystic fibrosis

  , RESPIRATORY MEDICINE, Vol: 100, Pages: 687-697, ISSN: 0954-6111
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  • Citations: 20
• Journal article
  Bayram H, Ito K, Issa R, Ito M, Sukkai M, Chung KFet al., 2006,

  Regulation of human lung epithelial cell numbers by diesel exhaust particles

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 27, Pages: 705-713, ISSN: 0903-1936
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  • Citations: 67
• Journal article
  Ingram W, Desai SR, Gibbs JSR, Mufti Get al., 2006,

  Reduced-intensity conditioned allogeneic haematopoietic transplantation in an adult with Langerhans cell histiocytosis and thrombocytopenia with absent radii

  , BONE MARROW TRANSPLANTATION, Vol: 37, Pages: 713-715, ISSN: 0268-3369
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  • Citations: 11
• Journal article
  Safinia L, Mantalaris A, Bismarck A, 2006,

  Nondestructive technique for the characterization of the pore size distribution of soft porous constructs for tissue engineering

  , LANGMUIR, Vol: 22, Pages: 3235-3242, ISSN: 0743-7463
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  • Citations: 45

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