Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Palmer LJ, Rye PJ, Gibson NA, Moffatt MF, Goldblatt J, Burton PR, Cookson WO, Lesouëf PNet al., 1999,

    Association of FcepsilonR1-beta polymorphisms with asthma and associated traits in Australian asthmatic families.

    , Clin Exp Allergy, Vol: 29, Pages: 1555-1562, ISSN: 0954-7894

    BACKGROUND: Asthma is a genetically complex disease, and is characterized by elevated serum immunoglobulin E (IgE) levels, elevated blood eosinophil counts and increased airway responsiveness. Polymorphisms in the beta subunit of the high affinity receptor for IgE (FcepsilonR1-beta) have been previously associated with these phenotypes and with an increased risk of asthma. OBJECTIVE: To investigate the association of all known bi-allelic polymorphisms in FcepsilonR1-beta to asthma and quantitative traits associated with asthma in a selected sample of Australian asthmatic children and their nuclear families. METHODS: Australian Caucasian nuclear families (n = 134 subjects) were recruited on the basis of a child proband with current, severe, symptomatic asthma. The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts and the dose-response slope of the forced expiratory volume in 1 s to histamine provocation. RESULTS: Neither the Leu181 nor the E237G mutations were detected in this population. Allele B of RsaI intron 2 (RsaI_in2*B) was significantly associated with physician-diagnosed asthma (ever) (P = 0.002). Alleles of both the RsaI_in2 and RsaI exon 7 (RsaI_ex7) polymorphisms were significantly associated with loge total serum IgE levels and the combined RAST index. RsaI_ex7 was also associated with loge blood eosinophil counts. These associations were independent of age, sex and familial correlations. CONCLUSION: This study supports a role for the FcepsilonR1-beta gene or a nearby gene in the pathogenesis of asthma.
  • Journal article
    Clarke J, Cota E, Fowler SB, Hamill SJet al., 1999,

    Folding studies of immunoglobulin-like β-sandwich proteins suggest that they share a common folding pathway

    , STRUCTURE WITH FOLDING & DESIGN, Vol: 7, Pages: 1145-1153, ISSN: 0969-2126
  • Journal article
    Negrete-Urtasun S, Reiter W, Diez E, Denison SH, Tilburn J, Espeso EA, Peñalva MA, Arst HNet al., 1999,

    Ambient pH signal transduction in <i>Aspergillus</i>:: completion of gene characterization

    , MOLECULAR MICROBIOLOGY, Vol: 33, Pages: 994-1003, ISSN: 0950-382X
  • Journal article
    Moffatt MF, James A, Ryan G, Musk AW, Cookson WOet al., 1999,

    Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample.

    , Thorax, Vol: 54, Pages: 757-761, ISSN: 0040-6376

    BACKGROUND: Tumour necrosis factor (TNF) is a potent pro-inflammatory cytokine which is prominent in asthmatic airways. TNF shows genetic variations in secretion which are linked to polymorphisms in the TNF gene complex and the surrounding major histocompatibility (MHC) locus. These polymorphisms do not seem to be themselves functionally important. In these circumstances, the identification of disease associated haplotypes (combination of alleles on individual chromosomes) may narrow the search for polymorphisms which alter gene function. METHODS: TNF-308, LTalpha NcoI, and HLA-DRB1 polymorphisms were investigated for association with asthma, bronchial responsiveness, and medication use in 1004 subjects in 230 families from a general population sample. RESULTS: The common LTalpha NcoI*1/TNF-308*2/HLA-DRB1*03 haplotype, which was present in 11% of unrelated individuals, was weakly associated with asthma (OR = 1.38, p = 0.016, corrected for familial correlation). The rarer LTalpha NcoI*1/TNF-308*2/HLA-DRB1*02 haplotype, which was found in 0.6% of unrelated subjects, was more strongly associated with asthma (OR = 6.68, p = 0.002). This haplotype also showed association with bronchial hyperresponsiveness (OR = 21.9, p = 0. 0000) and the use of inhaled or oral steroids (OR 8.0, p = 0.04). CONCLUSIONS: The results of this study show only two extended TNF/HLA-DR haplotypes to be associated with asthma. The search for functional alleles responsible for an increased risk of asthma should concentrate on the LTalpha NcoI*1/TNF-308*2/HLA-DRB1*02 haplotype.
  • Journal article
    Segers GC, Hamada W, Oliver RP, Spanu PDet al., 1999,

    Isolation and characterisation of five different hydrophobin-encoding cDNAs from the fungal tomato pathogen <i>Cladosporium fulvum</i>

    , MOLECULAR AND GENERAL GENETICS, Vol: 261, Pages: 644-652, ISSN: 0026-8925
  • Journal article
    Anderson GG, Cookson WO, 1999,

    Recent advances in the genetics of allergy and asthma.

    , Mol Med Today, Vol: 5, Pages: 264-273, ISSN: 1357-4310

    Asthma is a common condition that results from the interaction of an unknown number of genes with environmental factors. About 10% of children have asthma, usually as part of a syndrome of atopy, which is characterized by the presence of allergy, asthma, seasonal rhinitis and eczema, and tends to occur in familial clusters. The incidence of asthma is lower in adults (5%) and a significant proportion is seen without an atopic background. The prevalence of asthma has increased substantially over the past decades, particularly in the western world. Allergy and asthma are not inherited as single-gene disorders and do not show a simple pattern of inheritance. Environmental and genetic factors interact in a complex fashion to produce disease susceptibility and expression. Here, we describe the recent advances in the understanding of the inherited susceptibility to asthma and atopy and discuss their potential implications.
  • Journal article
    Fisher MC, White TJ, Taylor JW, 1999,

    Primers for genotyping single nucleotide polymorphisms and microsatellites in the pathogenic fungus <i>Coccidioides immitis</i>

    , MOLECULAR ECOLOGY, Vol: 8, Pages: 1082-1084, ISSN: 0962-1083
  • Journal article
    Hutchings H, Stahmann KP, Roels S, Espeso EA, Timberlake WE, Arst HN, Tilburn Jet al., 1999,

    The multiply-regulated <i>gabA</i> gene encoding the GABA permease of <i>Aspergillus nidulans</i>:: a score of exons

    , MOLECULAR MICROBIOLOGY, Vol: 32, Pages: 557-568, ISSN: 0950-382X
  • Journal article
    Moffatt MF, Cookson WO, 1999,

    Gene therapy for peanut allergy.

    , Nat Med, Vol: 5, Pages: 380-381, ISSN: 1078-8956
  • Journal article
    Alton EWFW, Stern M, Farley R, Jaffe A, Chadwick SL, Phillips J, Davies J, Smith SN, Browning J, Davies MG, Hodson ME, Durham SR, Li D, Jeffery PK, Scallan M, Balfour R, Eastman SJ, Cheng SH, Smith AE, Meeker D, Geddes DMet al., 1999,

    Cationic lipid-mediated <i>CFTR</i> gene transfer to the lungs and nose of patients with cystic fibrosis:: a double-blind placebo-controlled trial

    , LANCET, Vol: 353, Pages: 947-954, ISSN: 0140-6736

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1255&limit=10&resgrpMemberPubs=true&resgrpMemberPubs=true&page=420&respub-action=search.html Current Millis: 1748042887859 Current Time: Sat May 24 00:28:07 BST 2025

General enquiries

 For any enquiries about the Fungal Science Network at Imperial, please contact:

fungalnetwork@imperial.ac.uk