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  • Journal article
    Tilburn J, Sanchez-Ferrero JC, Reoyo E, Arst HN Jr, Penalva MAet al., 2005,

    Mutational analysis of the pH signal transduction component PalC of Aspergillus nidulans supports distant similarity to BRO1 family members

    , Genetics, Vol: 171, Pages: 393-401
  • Journal article
    Davies JC, Alton E, Griesenbach U, 2005,

    Cystic fibrosis modifier genes

    , Journal of the Royal Society of Medicine, Vol: 98, Pages: 47-54
  • Journal article
    Adcock IM, Ito K, 2005,

    Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.

    , Proc Am Thorac Soc, Vol: 2, Pages: 313-319, ISSN: 1546-3222

    Lung function measures in patients with chronic obstructive pulmonary disease remain insensitive to corticosteroid actions, in contrast to the clinical improvements observed in most patients with asthma. By uncovering the reason for this paradox, physicians should be able to implement treatment regimens that restore corticosteroid sensitivity. Corticosteroids exert their effects by binding to a cytoplasmic glucocorticoid receptor, which is subjected to post-translational modification by phosphorylation. Receptor phosphorylation may influence hormone binding and nuclear translocation, as well as alter other glucocorticoid receptor interactions, its protein half-life, and downregulation processes. This suggests that a "phosphorylation code" may exist for glucocorticoid receptor function. Oxidative stress due to cigarette smoke may also be a mechanism for the corticosteroid resistance observed in chronic obstructive pulmonary disease, as it enhances proinflammatory transcription. Reduced glucocorticoid nuclear translocation along with attenuated histone deacetylase activity may be partially responsible for this effect. Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease.
  • Journal article
    Bailly C, Kluza J, Martin C, Ellis T, Waring MJet al., 2005,

    DNase I footprinting of small molecule binding sites on DNA.

    , Methods Mol Biol, Vol: 288, Pages: 319-342, ISSN: 1064-3745

    Nuclease footprinting techniques were initially developed to investigate protein-deoxyribonucleic acid (DNA) interactions but these tools of molecular biology have also become instrumental for probing sequence-selective binding of small molecules to DNA. Here, the method is described and technical details are given for performing deoxyribonuclease (DNase) I footprinting with DNA-binding drugs. An example is presented where DNase I is used (as well as DNase II and micrococcal nuclease) to probe the patterns of sequence-selective recognition of DNA by the anticancer antibiotic actinomycin D. DNase I is a convenient endonuclease for detecting and locating the position of actinomycin-binding sites within GC-rich sequences.
  • Report
    Bismarck A, Hofmeier M, Jannerfeldt G, Meier Cet al., 2005,

    NAMAS project 2001 final report

    , Sulzer Composite Report, SCO_TB2002_001
  • Journal article
    Espeso EA, Cobeno L, Arst HN Jr, 2005,

    Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identification

    , Genetics, Vol: 171, Pages: 835-838
  • Journal article
    Davies JC, Alton EWFW, 2005,

    Airway Gene Therapy

    , NON-VIRAL VECTORS FOR GENE THERAPY, SECOND EDITION: PART 2, Vol: 54, Pages: 291-314, ISSN: 0065-2660
  • Report
    Bismarck A, Hofmeier M, 2005,

    Effect of thermal desizing of T1000GB fibers on the mechanical properties of carbon fiber/poly (ether ether ketone) (PEEK) composite tapes

    , Gurit Suprem Report, GS_TB2002_010
  • Journal article
    Green SJ, Khan SS, Desai SR, 2004,

    "Aunt Minnies" of thoracic high-resolution CT

    , Radiology Now, Vol: 21, Pages: 20-24, ISSN: 1461-4650

    The present review has discussed the characteristic HRCT appearances of some diffuse lung disease. The relationship of HRCT patterns with histopathological appearances have been also been stressed. There can be little doubt that HRCT is a vital component of the investigation of patients with suspected DILD and it is clear that accurate diagnoses can be made on the basis of HRCT findings in some patients, without the need for more invasive procedures.
  • Journal article
    Blaker JJ, Bismarck A, Nazhat SN, Maquet V, Lim J, Boccaccini ARet al., 2004,

    In vitro degradation behaviour of bioglass®-filled polylactide foams: Surface, thermal and mechanical analysis

    , Transactions 7th World Biomaterials Congress

    The thermal, mechanical and degradation behavior of Bioglass®-filled polyactide foams were investigated. The preparation of Bioglass-filled foams involved a thermally induced phase separation (TIPS) process and were incubated in both PBS and SBF solutions at 37°C for varying time periods to six months. The foams were examined using scanning electron microscopy (SEM), X-ray diffraction (XRD) and Raman Spectroscopy to verify the formation and crystallization of HA on their surfaces. The foams show high porosities, with a bimodal pore size distribution, macropores of ∼100μm diameter and interconnected micropores of 10-50 μm diameter.

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