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  • Journal article
    Palmer LJ, Paré PD, Faux JA, Moffatt MF, Daniels SE, LeSouëf PN, Bremner PR, Mockford E, Gracey M, Spargo R, Musk AW, Cookson WOet al., 1997,

    Fc epsilon R1-beta polymorphism and total serum IgE levels in endemically parasitized Australian aborigines.

    , Am J Hum Genet, Vol: 61, Pages: 182-188, ISSN: 0002-9297

    Endemic helminthic infection is a major public-health problem and affects a large proportion of the world's population. In Australia, helminthic infection is endemic in Aboriginal communities living in tropical northern regions of the continent. Such infection is associated with nonspecific (polyclonal) stimulation of IgE synthesis and highly elevated total serum IgE levels. There is evidence that worm-infection variance (i.e., human capacity of resistance) and total serum IgE levels may be related to the presence of a major codominant gene. The beta chain of the high-affinity IgE receptor, Fc epsilon R1-beta, has been previously identified as a candidate for the close genetic linkage of the 11q13 region to IgE responses in several populations. We show a biallelic RsaI polymorphism in Fc epsilon R1-beta to be associated with total serum IgE levels (P = .0001) in a tropical population of endemically parasitized Australian Aborigines (n = 234 subjects). The polymorphism explained 12.4% of the total residual variation in serum total IgE and showed a significant (P = .0000) additive relationship with total serum IgE levels, across the three genotypes. These associations were independent of familial correlations, age, gender, racial admixture, or smoking status. Alleles of a microsatellite repeat in intron 5 of the same gene showed similar associations. The results suggest that variation in Fc epsilon R1-beta may regulate IgE-mediated immune responses in this population.
  • Journal article
    Desai SR, Nicholson AG, Stewart S, Twentyman OM, Flower CDR, Hansell DMet al., 1997,

    Benign pulmonary lymphocytic infiltration and amyloidosis: Computed tomographic and pathologic features in three cases

    , JOURNAL OF THORACIC IMAGING, Vol: 12, Pages: 215-220, ISSN: 0883-5993
  • Journal article
    Davies JC, Stern M, Dewar A, Caplen NJ, Munkonge FM, Pitt T, Sorgi F, Huang L, Bush A, Geddes DM, Alton EWFWet al., 1997,

    CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium

    , AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 16, Pages: 657-663, ISSN: 1044-1549
  • Journal article
    Davidson SJ, Burman JF, Davies J, Bush Aet al., 1997,

    Cystic fibrosis and factor XII deficiency

    , THROMBOSIS AND HAEMOSTASIS, Pages: PS869-PS869, ISSN: 0340-6245
  • Journal article
    Dekker JW, Nizankowska E, Schmitz-Schumann M, Pile K, Bochenek G, Dyczek A, Cookson WO, Szczeklik Aet al., 1997,

    Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes.

    , Clin Exp Allergy, Vol: 27, Pages: 574-577, ISSN: 0954-7894

    BACKGROUND: Aspirin-induced asthma (AIA) affects one in 10 individuals with adult-onset asthma. It is not known if aspirin sensitivity is due to immune mechanisms or to interference with biochemical pathways. OBJECTIVE: The study aimed to test for possible involvement of the genes of the Major Histocompatibility Complex (MHC) in AIA. METHODS: HLA-DPB1 and HLA-DRB1 genotyping was carried out by DNA methods in 59 patients with positive challenge tests for AIA and in 48 normal and 57 asthmatic controls. RESULTS: The DPB1*0301 frequency was increased in AIA patients when compared with normal controls (19.5% vs 5.2%, Odds Ratio = 4.4, 95% Confidence Interval (CI) 1.6-12.1, P = 0.002), and compared with asthmatic controls (4.4%, OR = 5.3, 95% CI = 1.9-14.4, P = 0.0001). The frequency of DPB1*0401 in AIA subjects was decreased when compared with normal controls (28.8% vs 49.0%, OR = 0.42, 95% CI = 0.24-0.74, P = 0.003) and asthmatic controls (45.6%, OR = 0.48, 95% CI = 0.28-0.83, P = 0.008). The results remained significant when corrected for multiple comparisons. There were no significant HLA-DRB1 associations with AIA. CONCLUSION: The presence of an HLA association suggests that immune recognition of an unknown antigen may be part of the aetiology of AIA.
  • Journal article
    Arst HN, 1997,

    New evidence for old detective work

    , MICROBIOLOGY-UK, Vol: 143, Pages: 1481-1482, ISSN: 1350-0872
  • Journal article
    Faux JA, Moffatt MF, Lalvani A, Dekker J, Warrell DA, Cookson WOCet al., 1997,

    Sensitivity to bee and wasp venoms: Association with specific IgE responses to the bee and wasp venom and HLA DRB1 and DPB1

    , CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 27, Pages: 578-583, ISSN: 0954-7894
  • Journal article
    Desai SR, Hansell DM, 1997,

    Small airways disease: Expiratory computed tomography comes of age

    , CLINICAL RADIOLOGY, Vol: 52, Pages: 332-337, ISSN: 0009-9260
  • Journal article
    Davies J, Trindale M, Wallis C, Rosenthal M, Bush Aet al., 1997,

    The clinical use of rhDNAse.

    , Pediatr Pulmonol, Vol: 23 Suppl S16, Pages: 273-274
  • Journal article
    Davies J, Trindade MT, Wallis C, Rosenthal M, Crawford O, Bush Aet al., 1997,

    Retrospective review of the effects of rhDNase in children with cystic fibrosis

    , PEDIATRIC PULMONOLOGY, Vol: 23, Pages: 243-248, ISSN: 8755-6863

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