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  • Journal article
    Arst HN, 1997,

    Cosying up to MoCo

    , MICROBIOLOGY-UK, Vol: 143, Pages: 1037-1037, ISSN: 1350-0872
  • Journal article
    Moffatt MF, Cookson WO, 1997,

    Tumour necrosis factor haplotypes and asthma.

    , Hum Mol Genet, Vol: 6, Pages: 551-554, ISSN: 0964-6906

    Airway inflammation is a prominent feature of asthma. The pro-inflammatory cytokine Tumour Necrosis Factor shows constitutional variation in its level of secretion, which is linked to polymorphisms within the TNF gene complex and the surrounding MHC. In this study, 413 subjects in 88 nuclear families from a general population sample were examined for association with asthma and TNF polymorphisms. Ninety-two subjects were asthmatic, as defined by questionnaire. Asthma was significantly more common in subjects with allele 1 of the LT alpha NcoI polymorphism (LT alpha NcoI*1) (p = 0.005), and allele 2 of the TNF-308 polymorphism (TNF-308*2) (p = 0.004). The association was confined to the LT alpha NcoI*1/TNF-308*2 haplotype, so that it was not possible to differentiate between the effects of LT alpha NcoI and TNF-308 alleles. The HLA-DR locus was excluded as a cause of this association. The results suggest that genetic influences on inflammation may be important in the pathogenesis of asthma.
  • Journal article
    NegreteUrtasun S, Denison SH, Arst HN, 1997,

    Characterization of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologs

    , JOURNAL OF BACTERIOLOGY, Vol: 179, Pages: 1832-1835, ISSN: 0021-9193
  • Journal article
    Cookson WO, Moffatt MF, 1997,

    Asthma: an epidemic in the absence of infection?

    , Science, Vol: 275, Pages: 41-42, ISSN: 0036-8075
  • Conference paper
    Moffatt MF, Cookson WOCM, 1997,

    Linkage and candidate gene studies in asthma

    , ISSN: 1073-449X
    • Cite
    • Citations: 25
  • Journal article
    Desai SR, Hansell DM, 1997,

    Lung imaging in the adult respiratory distress syndrome: Current practice and new insights

    , INTENSIVE CARE MEDICINE, Vol: 23, Pages: 7-15, ISSN: 0342-4642
  • Journal article
    Sidhu PS, Desai SR, 1997,

    A simple and reproducible method for assessing intimal-medial thickness of the common carotid artery

    , BRITISH JOURNAL OF RADIOLOGY, Vol: 70, Pages: 85-89, ISSN: 0007-1285
  • Journal article
    Moffatt MF, Schou C, Faux JA, Cookson WOet al., 1997,

    Germline TCR-A restriction of immunoglobulin E responses to allergen.

    , Immunogenetics, Vol: 46, Pages: 226-230, ISSN: 0093-7711

    Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1(*)2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1(*)1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1(*)2 and HLA-DRB1(*)1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.
  • Journal article
    Davies J, Trindale M, Wallis C, Rosenthal M, Bush Aet al., 1997,

    The clinical use of rhDNAse

    , PEDIATRIC PULMONOLOGY, Pages: 273-274, ISSN: 8755-6863
  • Journal article
    Bismarck A, Tahhan R, Springer J, Schulz A, Klapotke TM, Zell H, Michaeli Wet al., 1997,

    Influence of fluorination on the properties of carbon fibers

    , Journal of Fluorine Chemistry, Vol: 84, Pages: 127-134

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