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• Journal article
  Weiland SK, Björkstén B, Brunekreef B, Cookson WOC, von Mutius E, Strachan DPet al., 2004,

  Phase II of the international study of asthma and allergies in childhood (ISAAC II): rationale and methods

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 406-412, ISSN: 0903-1936
  • Cite
  • Citations: 363
• Journal article
  Caramori G, Ito K, Adcock IM, 2004,

  Targeting Th2 cells in asthmatic airways.

  , Curr Drug Targets Inflamm Allergy, Vol: 3, Pages: 243-255, ISSN: 1568-010X

  The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients. The current asthma therapies are not cures and symptoms return soon after the treatment is stopped even after long-term therapy. In addition, severe glucocorticoid-dependent and -resistant asthma still represents a great clinical burden accounting for approximately 50% of the health care costs of asthma and reducing the side-effects of glucocorticoids using novel dissociated steroids, soft steroids or with steroid-sparing agents will prove beneficial. Furthermore, the mechanisms involved in the persistence of inflammation are poorly understood and the reasons why some patients have severe life threatening asthma and others have very mild disease are still unknown. Hopefully, it will soon be possible to identify and manipulate the molecular switches that result in asthmatic inflammation. This may lead to the treatment of susceptible individuals at birth or in the early years and thus prevent the disease from becoming established. Drug development for asthma has been directed at improving currently available drugs and finding new compounds that usually target the Th2-driven airway inflammatory response. Several new drugs have been developed to target specific components of the Th2-driven inflammatory process in asthma (e.g. IgE antibodies, cytokines and/or chemokines, immunomodulators, antagonists of adhesion molecules), although they have not yet been proven to be particularly effective. Some of these new Th2-oriented strategies may in the future not only control symptoms, but also potentially prevent or cure the disease.

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• Journal article
  Wu MJ, Shu KH, Cheng CH, Chen CHet al., 2004,

  Sirolimus in chronic allograft nephropathy

  , TRANSPLANTATION PROCEEDINGS, Vol: 36, Pages: 2053-2055, ISSN: 0041-1345
  • Cite
  • Citations: 13
• Journal article
  Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RAG, Nowicki B, Le Bouguénec C, Lea SM, Matthews Set al., 2004,

  An atomic resolution model for assembly, architecture, and function of the Dr adhesins

  , MOLECULAR CELL, Vol: 15, Pages: 647-657, ISSN: 1097-2765
  • Cite
  • Citations: 97
• Journal article
  Caramori G, Ito K, Adcock IM, 2004,

  Transcription factors in asthma and COPD

  , IDRUGS, Vol: 7, Pages: 764-770, ISSN: 1369-7056
  • Cite
  • Citations: 15
• Journal article
  Desai SR, Veeraraghavan S, Hanser DM, Nikolakopolou A, Goh NSL, Nicholson AG, Colby TV, Denton CP, Black CM, Ois RMD, Wells AUet al., 2004,

  CT features of lung disease in patients with systemic sclerosis: Comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia

  , RADIOLOGY, Vol: 232, Pages: 560-567, ISSN: 0033-8419
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  • Citations: 270
• Journal article
  Leake JR, McKendrick SL, Bidartondo M, Read DJet al., 2004,

  Symbiotic germination and development of the myco-heterotroph Monotropa hypopitys in nature and its requirement for locally distributed Tricholoma spp.

  , New Phytologist, Vol: 163, Pages: 405-423, ISSN: 0028-646X

  Germination and symbiotic development of the myco-heterotrophic plant Monotropa hypopitys were studied by sequential recovery of packets of seed buried in dune slacks in relation to distance from mature M. hypopitys and presence and absence of shoots of its autotrophic coassociate Salix repens.Fungal associates of M. hypopitys growing under S. repens in the dune slacks, and under S. caprea and Pinus sylvestris at two other locations in the UK, were identified by molecular analysis.While the earliest stage of germination could be found in the absence both of mature M. hypopitys, and S. repens, further development was dependent upon mycorrhizal colonisation, which was most common close to these plants. Molecular analysis showed that when growing with Salix, M. hypopitys associated with the Salix-specific ectomycorrhizal fungus Tricholoma cingulatum, whereas under Pinus it was colonised by the closely related, Pinaceae-specific, T. terreum.We establish the first definitive chronology of development of M. hypopitys and highlight its critical dependence upon, and specificity for, locally distributed Tricholoma species that link the myco-heterotroph to its autotrophic coassociates. (C) New Phytologist (2004).

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• Journal article
  Cosío BG, Mann B, Ito K, Jazrawi E, Barnes PJ, Chung KF, Adcock IMet al., 2004,

  Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 170, Pages: 141-147, ISSN: 1073-449X
  • Cite
  • Citations: 205
• Journal article
  McShane D, Davies JC, Wodehouse T, Bush A, Geddes D, Alton EWFWet al., 2004,

  Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 95-100, ISSN: 0903-1936
  • Cite
  • Citations: 32
• Journal article
  Anderson KL, Cota E, Simpson P, Chen HA, du Merle L, Le Bouguénec C, Matthews Set al., 2004,

  Letter to the Editor: Complete resonance assignments of a 'donor-strand complemented' AfaE: The afimbrial adhesin from Diffusely Adherent <i>E-coli</i>

  , JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 409-410, ISSN: 0925-2738
  • Cite
  • Citations: 10

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