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• Journal article
  Davies J, Trindale M, Wallis C, Rosenthal M, Bush Aet al., 1997,

  The clinical use of rhDNAse

  , PEDIATRIC PULMONOLOGY, Pages: 273-274, ISSN: 8755-6863
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  • Citations: 5
• Journal article
  Bismarck A, Tahhan R, Springer J, Schulz A, Klapotke TM, Zell H, Michaeli Wet al., 1997,

  Influence of fluorination on the properties of carbon fibers

  , Journal of Fluorine Chemistry, Vol: 84, Pages: 127-134
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• Journal article
  Davies J, Dewar A, Bush A, Geddes DM, Alton EWFWet al., 1996,

  Pseudomonas aeruginosa adherence to cystic fibrosis respiratory epithelium is reduced by anti-asialo GM1 antibody and neuraminidase inhibition

  , Thorax, Vol: 51, ISSN: 0040-6376

  Pseudomonas aeruginosa (P. aer), the bacterial pathogen responsible for most of the lung damage in cystic fibrosis (CF), adheres in greater numbers to cells of CF origin than to non-CF cells, which in part may explain the close relationship between this infection and CF. We have previously shown that this increased adherence results from the absence of normal CFTR, in that P. aer binding is reduced after in vitro liposome-mediated CFTR gene transfer. Previous studies have demonstrated that P. aer binds to asialylated glycolipids which are present in increased numbers on the surface of CF cells, and that neuraminidase, an exoproduct of P. aer, by cleaving sialic acid from glycolipids, can increase the availability of such binding sites. Mechanisms to reduce the adherence of P. aer to CF cells, thought to be the initial step in the process of infection, could potentially delay or prevent pulmonary colonisation and the deterioration in lung function which ensues. We have studied the possibility of reducing binding to asialo GM1 receptors, both by blocking with anti-asialo GM1 antibody, and with the inhibitor, 2,3-dehydo-2-deoxy-N-acetylneuraminic acid (DANA), to prevent neuraminidase-mediated increase in asialylated glycolipids. Nasal epithelial cells from 9 CF subjects were divided into 3 aliquots: each was exposed to a fixed concentration of a non-mucoid laboratory strain of P. aer (strain K), one aliquot after 1 hour incubation with a polyclonal rabbit anti-asialo GM1 antibody, and another in the presence of 50 μM DANA. A further 3 samples were used to study the affect of a control polyclonal anti-mouse antibody. Bacterial adherence to the apical surface of ciliated epithelial cells was quantified in a blinded fashion by direct visualisation using scanning electron microscopy. Pre-treatment with anti-asialo GM1 antibody resulted in a reduction in bacterial binding to every sample, with a mean reduction of 50% (mean binding /10 cells: baseline 9.7; anti-asialo GM1

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• Journal article
  Sugimoto N, Nakano S, Yoneyama M, Honda Ket al., 1996,

  Improved thermodynamic parameters and helix initiation factor to predict stability of DNA duplexes.

  , Nucleic Acids Res, Vol: 24, Pages: 4501-4505, ISSN: 0305-1048

  To improve the previous DNA/DNA nearest-neighbor parameters, thermodynamic parameters (deltaH degrees, deltaS degrees and deltaG degrees) of 50 DNA/DNA duplexes were measured. Enthalpy change of a helix initiation factor is also considered though the parameters reported recently did not contain the factor. A helix initiation factor for DNA/DNA duplex determined here was the same as that of RNA/RNA duplex (deltaG degrees(37) = 3.4 kcal/mol). The improved nearest-neighbor parameters reproduced not only these 50 experimental values used here but also 15 other experimental values obtained in different studies. Comparing deltaG degrees(37) values of DNA/DNA nearest-neighbor parameters obtained here with those of RNA/RNA and RNA/DNA, RNA/RNA duplex was generally the most stable of the three kinds of duplexes with the same nearest-neighbor sequences. Which is more stable between DNA/DNA and RNA/DNA duplexes is sequence dependent.

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• Journal article
  Fisher MC, Viney ME, 1996,

  Microsatellites of the parasitic nematode Strongyloides ratti

  , MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 80, Pages: 221-224, ISSN: 0166-6851
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  • Citations: 24
• Journal article
  Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, leSouef PN, Lathrop GM, Musk AW, Cookson WOCMet al., 1996,

  A genome-wide search for quantitative trait loci underlying asthma

  , NATURE, Vol: 383, Pages: 247-250, ISSN: 0028-0836
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  • Citations: 631
• Journal article
  Walley AJ, Cookson WO, 1996,

  Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy.

  , J Med Genet, Vol: 33, Pages: 689-692, ISSN: 0022-2593

  The cytokine cluster located on chromosome 5 has been shown by linkage studies to play a role in the genetic determination of circulating immunoglobulin E (IgE) levels in atopic subjects. In the study presented here, the reported chromosome 5 linkage has been investigated in two sets of subjects. The first consisted of a general population sample of 230 nuclear families (n = 1004) from Busselton, a small West Australian country town. The second group consisted of 124 unrelated atopic asthmatics and 59 unrelated non-atopic, non-asthmatic controls, all resident in the Oxfordshire Regional Health Authority area in the United Kingdom. A previously reported interleukin-4 (II-4) promoter polymorphism (-590 C-->T) was analysed in these populations by a newly designed method of specific PCR amplification and BsmFI restriction endonuclease digestion. In the Busselton population the polymorphism was shown to be weakly associated with specific IgE to house dust mite (Mann-Whitney-U test, p = 0.013) and to wheeze (MWU test, p = 0.029), but not with specific IgE to grass pollen, total serum IgE, bronchial hyperresponsiveness, eosinophil count, or asthma. In the Oxfordshire subjects there were no statistically significant associations with any measure of asthma or atopy. These data show that the -590 C-->T II-4 promoter polymorphism is only weakly associated with certain measures of asthma and atopy in some subjects. It was specifically not associated with serum IgE concentration or asthma in either of the two groups in this study.

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• Journal article
  Hill MR, Cookson WO, 1996,

  A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.

  , Hum Mol Genet, Vol: 5, Pages: 959-962, ISSN: 0964-6906

  The high affinity receptor for IgE (Fc epsilon RI) has a central role in mast cell degranulation and IgE mediated allergy. A systematic search through the coding regions of the beta subunit of Fc epsilon RI (Fc epsilon RI-beta) has identified a novel coding polymorphism in exon seven. An adenine to guanine substitution changes amino acid residue 237 from glutamic acid to glycine (E237G), in the cytoplasmic tail of the protein. E237G is predicted to introduce a hydrophobicity change within the C-terminus of Fc epsilon RI-beta. It is adjacent to the immunoreceptor tyrosine activation motif (ITAM), and may affect the intracellular signalling capacity of Fc epsilon RI. E237G was detected in 53 subjects from an Australian general population sample of 1004 individuals (5.3%). E237G positive subjects had a significantly elevated skin test response to grass (p = 0.0004) and house dust mite (p = 0.04), RAST to grass (p = 0.002) and bronchial reactivity to methacholine (p = 0.0009). The relative risk of individuals with E237G having asthma compared to subjects without the variant was 2.3 (95% CI 1.26-4.19; p = 0.005).

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• Journal article
  Arst HN, Sheerins A, 1996,

  Erratum: Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans (Molecular Microbiology (1996) 19 (5), 1019-1024)

  , Molecular Microbiology, Vol: 20, ISSN: 0950-382X
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• Journal article
  Moffatt M, Cookson W, 1996,

  Naked DNA: new shots for allergy?

  , Nat Med, Vol: 2, Pages: 515-516, ISSN: 1078-8956
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