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  • Journal article
    MacCabe AP, Vanhanen S, Gelpke MDS, van de Vondervoort PJI, Arst HN, Visser Jet al., 1998,

    Identification, cloning and sequence of the <i>Aspergillus niger areA</i> wide domain regulatory gene controlling nitrogen utilisation

    , BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, Vol: 1396, Pages: 163-168, ISSN: 0167-4781
  • Journal article
    Moffatt MF, Cookson WOCM, 1998,

    The genetics of asthma and allergy

    , Revue Francaise d'Allergologie et d'Immunologie Clinique, Vol: 38, ISSN: 0335-7457
  • Journal article
    Cookson WOCM, 1998,

    Genetics and asthma

    , Research in Immunology, Vol: 149, Pages: 181-187, ISSN: 0923-2494
  • Journal article
    Cox HE, Moffatt MF, Faux JA, Walley AJ, Coleman R, Trembath RC, Cookson WO, Harper JIet al., 1998,

    Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor.

    , Br J Dermatol, Vol: 138, Pages: 182-187, ISSN: 0007-0963

    IgE dysregulation is a major pathogenic feature of atopic dermatitis and other IgE-mediated allergic diseases such as asthma and rhinitis. Allergen complexed to IgE binds to the high affinity receptor for IgE (Fc epsilon RI) on the surface of epidermal Langerhans cells, mast cells and basophils, triggering the release of inflammatory mediators. The beta subunit of Fc epsilon RI has been localized to human chromosome 11q12-13, and variants within this gene have been shown to associate with asthma and measures of atopy. We have tested several polymorphisms within Fc epsilon RI-beta for association to atopic dermatitis in a panel of 60 families (panel A), recruited through a proband with atopic dermatitis. The findings were tested in a second panel of families (panel B). Significant sharing of maternal alleles was seen for atopic dermatitis and allele 2 of RsaI intron 2 (RsaIvin2*2) (P = 0.0022) and allele 1 of RsaI exon 7 (RsaIvex7*1) (P = 0.0036) Fc epsilon RI-beta gene polymorphisms. These findings were replicated in Panel B, confirming the association of Fc epsilon RI-beta RsaI polymorphisms with atopic dermatitis. The combined significance of the association of atopic dermatitis to RsaI polymorphisms was P = 0.0002 (RsaIvin2*2) and P = 0.00034 (RsaIvex7*1). The polymorphisms also showed association with asthma: P = 0.0068 (RsaIvin2*2) and P = 0.018 (RsaIvex7*1). Polymorphisms within the Fc epsilon RI-beta gene are strongly associated with atopic dermatitis.
  • Journal article
    Wiltshire S, Bhattacharyya S, Faux JA, Leaves NI, Daniels SE, Moffatt MF, James A, Musk AW, Cookson WOet al., 1998,

    A genome scan for loci influencing total serum immunoglobulin levels: possible linkage of IgA to the chromosome 13 atopy locus.

    , Hum Mol Genet, Vol: 7, Pages: 27-31, ISSN: 0964-6906

    Immunoglobulins play an essential part in the immune system, and immunoglobulin deficiencies can have profound medical consequences. The genetic control and regulation of the immunoglobulin response is therefore of interest. Previous investigations have identified a number of loci influencing total and specific IgE levels. In this study, 80 nuclear families have been examined for linkage of total serum IgA, IgG and IgM levels to a genome-wide panel of microsatellite markers. Potential quantitative trait loci influencing IgA levels have been identified on chromosomes 10 and 13, and possible loci influencing IgG levels were found on chromosomes 3 and 13. No significant linkages to IgM levels were found. The linkage of IgA on chromosome 13 was to a marker previously linked to IgE responses (atopy). Linkage to IgG was in the same region but to a more distal marker. None of the factors known to influence immunoglobulin expression map to the loci identified in the present study. These loci are therefore likely to contain previously unrecognized components of the immunoregulatory system.
  • Journal article
    Davies J, Jaffé A, Bush A, 1998,

    Distal 10q trisomy syndrome with unusual cardiac and pulmonary abnormalities

    , JOURNAL OF MEDICAL GENETICS, Vol: 35, Pages: 72-74, ISSN: 0022-2593
  • Conference paper
    Habel WR, Hillemeier B, Bismarck A, Springer Jet al., 1998,

    How to achieve the desired strain transfer for fibre-optic microdeformation measurements in cementitious building materials at early ages?

    , European Workshop on Optical Fibre Sensors, Proceedings of the Society of Photo-Optical Instrumentation Engineers, Publisher: SPIE, Pages: 59-63
  • Journal article
    Song B, Bismarck A, Tahhan R, Springer Jet al., 1998,

    A generalized Drop Length-Height Method for Determination of Contact Angle in Drop-on-Fiber Systems

    , Journal of Colloid and Interface Science, Vol: 197, Pages: 68-77
  • Conference paper
    Cookson WO, 1998,

    Genetic aspects of atopic allergy.

    , Pages: 9-14, ISSN: 0105-4538
  • Journal article
    Bismarck A, Pfaffernoschke M, Selimovic M, Springer Jet al., 1998,

    Electrokinetic and contact angle measurements of grafted carbon fibers - Part III: Grafting of 2-(N,N-dimethylamino)ethylmethacrylate

    , Colloid and Polymer Science, Vol: 276, Pages: 1110-1116

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