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• Journal article
  Arst HN, Peñalva MA, 2003,

  pH regulation in <i>Aspergillus</i> and parallels with higher eukaryotic regulatory systems

  , TRENDS IN GENETICS, Vol: 19, Pages: 224-231, ISSN: 0168-9525
  • Author Web Link
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  • Citations: 109
• Journal article
  Cookson W, 2003,

  A new gene for asthma: would you ADAM and Eve it?

  , TRENDS IN GENETICS, Vol: 19, Pages: 169-172, ISSN: 0168-9525
  • Author Web Link
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  • Citations: 20
• Journal article
  Moffatt MF, Faux JA, Lester S, Paré P, McCluskey J, Spargo R, James A, Musk AW, Cookson WOCMet al., 2003,

  Atopy, respiratory function and HLA-DR in aboriginal Australians

  , HUMAN MOLECULAR GENETICS, Vol: 12, Pages: 625-630, ISSN: 0964-6906
  • Author Web Link
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  • Citations: 24
• Journal article
  Moffatt MF, Faux JA, Lester S, Paré P, McCluskey J, Spargo R, James A, Musk AW, Cookson WOCMet al., 2003,

  Atopy, respiratory function and HLA-DR in aboriginal Australians

  , Human Molecular Genetics, Vol: 12, Pages: 625-630, ISSN: 0964-6906

  The Class II genes of the MHC represent a major locus with quantified effects on atopic (allergic) phenotypes in many studies of westernized Caucasians. Although asthma is considered a disease of western societies, typical components of the asthma phenotype, such as elevations of the IgE, are seen with parasitic infestation. We have therefore investigated the effects of the HLA-DRB1 locus on asthma and its intermediate phenotypes in Aboriginal people from the Kimberly region of Australia who were suffering from endemic hookworm infection. Recognizable correlates of allergic asthma were present in the subjects, including skin test positivity to house dust mite (HDM), specific IgE responses to HDM, and the total serum IgE. HLA-DRB1 alleles did not predict the presence of asthma, but multi-allelic tests of association showed the locus accounted for ∼33% of the variance of the total serum IgE concentration and 17% of the variance of the specific IgE titres to HDM. Genetic admixture was excluded as a cause of the results. These effects of the MHC on IgE levels were an order of magnitude greater than that seen in Caucasians, consistent with the hypothesis that the genetic predisposition to allergic disease may be driven by adaptation to helminth infection. The results further suggest that parasitism per se is not protective against asthma.

  • Abstract
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  • Citations: 28
• Journal article
  Inoue K, Ozaki S, Ito K, Iseda T, Kawaguchi S, Ogawa M, Bae SC, Yamashita N, Itohara S, Kudo N, Ito Yet al., 2003,

  <i>Runx3</i> is essential for the target-specific axon pathfinding of <i>trkC</i>-expressing dorsal root ganglion neurons

  , BLOOD CELLS MOLECULES AND DISEASES, Vol: 30, Pages: 157-160, ISSN: 1079-9796
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  • Citations: 28
• Journal article
  Mangoni AA, Desai SR, Shaikh H, Barker RD, Mufti GJ, Jackson SHDet al., 2003,

  An unusual case of pneumonia

  , INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 57, Pages: 153-154, ISSN: 1368-5031
  • Author Web Link
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  • Citations: 1
• Journal article
  Vincent O, Rainbow L, Tilburn J, Arst HN, Peñalva MAet al., 2003,

  YPXL/I is a protein interaction motif recognized by <i>Aspergillus</i> PalA and its human homologue, AIP1/Alix

  , MOLECULAR AND CELLULAR BIOLOGY, Vol: 23, Pages: 1647-1655, ISSN: 0270-7306
  • Author Web Link
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  • Citations: 142
• Journal article
  Horsefield R, Yankovskaya V, Törnroth S, Luna-Chavez C, Stambouli E, Barber J, Byrne B, Cecchini G, Iwata Set al., 2003,

  Using rational screening and electron microscopy to optimize the crystallization of succinate:ubiquinone oxidoreductase from <i>Escherichia coli</i>

  , ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Vol: 59, Pages: 600-602, ISSN: 0907-4449
  • Author Web Link
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  • Citations: 10
• Journal article
  Kagoshima M, Ito K, Cosio B, Adcock IMet al., 2003,

  Glucocorticoid suppression of nuclear factor-κB: a role for histone modifications

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 31, Pages: 60-65, ISSN: 0300-5127
  • Cite
  • Citations: 51
• Journal article
  Yankovskaya V, Horsefield R, Törnroth S, Luna-Chavez C, Miyoshi H, Léger C, Byrne B, Cecchini G, Iwata Set al., 2003,

  Architecture of succinate dehydrogenase and reactive oxygen species generation

  , SCIENCE, Vol: 299, Pages: 700-704, ISSN: 0036-8075
  • Author Web Link
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  • Citations: 770

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