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  • Journal article
    DIALLINAS G, GORFINKIEL L, ARST HN, CECCHETTO G, SCAZZOCCHIO Cet al., 1995,

    GENETIC AND MOLECULAR CHARACTERIZATION OF A GENE ENCODING A WIDE SPECIFICITY PURINE PERMEASE OF ASPERGILLUS-NIDULANS REVEALS A NOVEL FAMILY OF TRANSPORTERS CONSERVED IN PROKARYOTES AND EUKARYOTES

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 8610-8622, ISSN: 0021-9258
  • Journal article
    Clutterbuck AJ, Arst H, 1995,

    Genetic nomenclature guide. Aspergillus nidulans.

    , Trends Genet, Pages: 13-14, ISSN: 0168-9525
  • Journal article
    TILBURN J, SARKAR S, WIDDICK DA, ESPESO EA, OREJAS M, MUNGROO J, PENALVA MA, ARST HNet al., 1995,

    THE ASPERGILLUS PACC ZINC-FINGER TRANSCRIPTION FACTOR MEDIATES REGULATION OF BOTH ACID-EXPRESSED AND ALKALINE-EXPRESSED GENES BY AMBIENT PH

    , EMBO JOURNAL, Vol: 14, Pages: 779-790, ISSN: 0261-4189
  • Journal article
    Hill MR, Cookson WO, 1995,

    Reply to “Atopy in Australia”

    , Nature Genetics, Vol: 10, ISSN: 1061-4036
  • Journal article
    Young RP, Barker RD, Pile KD, Cookson WO, Taylor AJet al., 1995,

    The association of HLA-DR3 with specific IgE to inhaled acid anhydrides.

    , Am J Respir Crit Care Med, Vol: 151, Pages: 219-221, ISSN: 1073-449X

    We have undertaken a case referent study of the association between HLA allele frequency and specific IgE antibody to acid anhydride-human serum albumin (AA-HSA) conjugates among acid anhydride workers. Thirty cases with radio-allergosorbent test score versus AA-HSA conjugates > 2 were compared with 30 referents without specific IgE selected from the same factory sites as the cases and matched for age, sex, duration of exposure, atopic status, and smoking habit. We found a significant excess of HLA-DR3 in the cases with specific IgE to acid anhydrides when compared with the referents (50% versus 14%, Fisher's statistic = 8.4; odds ratio = 6, p = 0.05 corrected). The excess of HLA-DR3 was particularly associated with IgE versus trimellitic anhydride, with HLA-DR3 present in eight of 11 workers with and in two of 14 referents without IgE (Fisher's statistic = 8.5, odds ratio = 16, p = 0.004). The proportion of HLA-DR3 among the phthalic anhydride workers was not different in those with IgE (two of 12) from their referents (two of 14). These findings suggest MHC II proteins are an important determinant of the specificity of the IgE response to an inhaled hapten.

  • Conference paper
    HENSEL M, TANG CM, ARST HN, HOLDEN DWet al., 1995,

    REGULATION OF FUNGAL EXTRACELLULAR PROTEASES AND THEIR ROLE IN MAMMALIAN PATHOGENESIS

    , Publisher: CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, Pages: S1065-S1070, ISSN: 0008-4026
  • Journal article
    Hensel M, Tang CM, Arst HN, Holden DWet al., 1995,

    Regulation of fungal extracellular proteases and their role in pathogenesis

    , Canadian Journal of Botany, Vol: 73
  • Journal article
    Byrne B, Fowler PA, Fraser M, Culler M, Templeton Aet al., 1995,

    GnSAF bioactivity present in serum from superovulated women is not blocked by inhibin antibody.

    , Biology of Reproduction, Vol: 52, Pages: 88-95

    Primary pituitary cultures from adult female rats were used to investigate gonadotropin surge attenuating factor (GnSAF) bioactivity. Serum from superovulated women was charcoal-treated and incubated with either an inhibin antibody (MC4), normal sheep serum (NSS), or serum-free defined medium (SFDM) before addition to cell culture. The reduction in GnRH-induced LH secretion (GnSAF bioactivity) produced by the serum (30.1 +/- 6.5%, p < 0.001, of control) was not altered by prior incubation with either MC4 or NSS (24.9 +/- 3.6 and 23.2 +/- 2.7%, p < 0.001, of control, respectively). This indicates that GnSAF bioactivity present in serum from superovulated women is not entirely attributable to inhibin. Recombinant human inhibin reduced basal FSH secretion to 24.6 +/- 4.7% (p < 0.001) of the control value. However, this was totally abolished by prior incubation with MC4, but not NSS. We have also shown that ovarian steroids are not responsible for GnSAF bioactivity in vitro. In conclusion, in contrast to findings in superovulated rats, inhibin antibody did not block GnSAF bioactivity in serum from superovulated women.

  • Journal article
    DIZIER MH, HILL M, JAMES A, FAUX J, RYAN G, LESOUEF P, LATHROP M, MUSK AW, DEMENAIS F, COOKSON Wet al., 1995,

    DETECTION OF A RECESSIVE MAJOR GENE FOR HIGH IGE LEVELS ACTING INDEPENDENTLY OF SPECIFIC RESPONSE TO ALLERGENS

    , GENETIC EPIDEMIOLOGY, Vol: 12, Pages: 93-105, ISSN: 0741-0395
  • Conference paper
    ARST HN, 1995,

    NITROGEN METABOLITE REPRESSION IN ASPERGILLUS-NIDULANS - AN HISTORICAL-PERSPECTIVE

    , 5th International Mycological Congress, Publisher: NATL RESEARCH COUNCIL CANADA, Pages: S148-S152, ISSN: 0008-4026

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