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  • Journal article
    Díez E, Alvaro J, Espeso EA, Rainbow L, Suárez T, Tilburn J, Arst HN, Peñalva MAet al., 2002,

    Activation of the <i>Aspergillus</i> PacC zinc finger transcription factor requires two proteolytic steps

    , EMBO JOURNAL, Vol: 21, Pages: 1350-1359, ISSN: 0261-4189
  • Journal article
    Jormakka M, Törnroth S, Byrne B, Iwata Set al., 2002,

    Molecular basis of proton motive force generation:: Structure of formate dehydrogenase-N

    , SCIENCE, Vol: 295, Pages: 1863-1868, ISSN: 0036-8075
  • Journal article
    Leaves NI, Bhattacharyya S, Wiltshire S, Cookson WOCMet al., 2002,

    A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus

    , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 10, Pages: 177-182, ISSN: 1018-4813
    • Cite
    • Citations: 14
  • Journal article
    Leaves NI, Bhattacharyya S, Wiltshire S, Cookson WOCMet al., 2002,

    A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus.

    , Eur J Hum Genet, Vol: 10, Pages: 177-182, ISSN: 1018-4813

    Non-specific bronchial hyper-responsiveness to various inhaled stimuli is a characteristic of asthma. We have previously shown linkage of bronchial responsiveness to methacholine (measured as dose-response slope (DRS)) and the peripheral blood eosinophil count (EOS) to chromosome 7. We have now further investigated these linkages by genotyping 49 microsatellite markers across the DRS locus on chromosome 7. The markers were spaced on average 2.6 cM apart and spanned a sex averaged cumulative genetic distance of 129 cM. Multipoint linkage to DRS was bimodal and dipped at the centromere. The two peaks of linkage were close to markers D7S484 (P=0.0003) and D7S669 (P=0.006) respectively. Separate testing for linkage to paternally and maternally derived alleles showed that the linkage near D7S484 was paternally derived (P<0.00001): maternally derived alleles did not exhibit significant linkage. The results indicate that two disparate loci may be influencing asthma from chromosome 7.
  • Journal article
    Bidartondo MI, Bruns TD, 2002,

    Fine-level mycorrhizal specificity in the Monotropoideae (Ericaceae): specificity for fungal species groups.

    , Molecular Ecology, Vol: 11, Pages: 557-569, ISSN: 0962-1083

    The Monotropoideae (Ericaceae) are non-photosynthetic angiosperms that obtain fixed carbon from basidiomycete ectomycorrhizal fungi. In previous work, we showed that each plant species is associated with a single genus or a set of closely related genera of ectomycorrhizal fungi. Here we show that the level of specificity is much higher. We used a molecular phylogenetic approach to contrast specificity patterns among eight plant lineages and three fungal genera. We relied on fungal nuclear internal transcribed spacer (nrITS) sequence data obtained from 161 basidiocarps and 85 monotropoid roots representing 286 sampled plants screened using restriction length polymorphisms. From the phylogenetic placement of fungal symbionts in fungal phylograms, we found that three basal (Sarcodes, Pterospora, Pleuricospora) and one derived lineage (Allotropa) of plants target narrow clades of closely related species groups of fungi, and four derived lineages (Monotropa hypopithys species group, Pityopus) target more distant species groups. Within most plant lineages, geography and photobiont association constrain specificity. Specificity extended further in Pterospora andromedea, in which sequence haplotypes at the plastid trn L-F region of 73 plants were significantly associated with different fungal species groups even in sympatry. These results indicate that both the macro- and microevolution of the Monotropoideae are tightly coupled to their mycorrhizal symbionts.
  • Conference paper
    Cookson WOC, 2002,

    Asthma genetics

    , 44th Annual Thomas L Petty Aspen Lung Conference, Publisher: ELSEVIER, Pages: 7S-13S, ISSN: 0012-3692
    • Cite
    • Citations: 66
  • Journal article
    Bismarck A, Menner A, Kumru ME, Saraç AS, Bistritz M, Schulz Eet al., 2002,

    Poly(carbazole-co-acrylamide) electrocoated carbon fibers and their adhesion behavior to an epoxy resin matrix

    , JOURNAL OF MATERIALS SCIENCE, Vol: 37, Pages: 461-471, ISSN: 0022-2461
  • Journal article
    Ito K, Adcock IM, 2002,

    Histone acetylation and histone deacetylation

    , Applied Biochemistry and Biotechnology Part B Molecular Biotechnology, Vol: 20, Pages: 99-106, ISSN: 1073-6085

    Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation - increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II. In contrast hypoacetylation of histones leads to tighter winding of DNA and reduced gene transcription. In this article we describe methods for measuring the histone acetyltransferase (HAT) and deacetylase (HDAC) activity of A549 cells. We initially describe methods examine whole cell HAT and HDAC activities and subsequently describe a technique for examining HAT activity associated with a specific co-activator CBP isolated by immunoprecipitation. These methods can also be applied to protein extracts from primary cells and from biopsy samples.
  • Journal article
    Bruns TD, Bidartondo MI, 2002,

    Molecular windows into the below-ground interactions of ectomycorrhizal fungi

    , Mycologist, Vol: 16, Pages: 47-50, ISSN: 0269-915X

    Over the past decade the use of molecular techniques has provided new ways to study old questions about how ectomycorrhizal fungi interact with each other and their environment. In their simplest form, these methods enable researchers to identify vegetative stages of fungi that would be difficult, slow, or impossible to identify by morphological or culture-based methods. This has resulted in quantitative views of complex fungal communities, which in turn have revealed new and unexpected patterns in community structure. In addition, molecular methods have been used to identify individual genotypes of fungi. This information has provided insights into the way that particular species of ectomycorrhizal fungi spread in nature. In this article we will mention the basic techniques and briefly discuss some of the findings that have resulted. Advances in this field have recently been comprehensively reviewed for scientific audiences, and we refer readers that have a more technical interest or a need to access the current literature to these reviews (Dahlberg, 2001; Horton & Bruns, 2001).
  • Journal article
    Fisher MC, Koenig GL, White TJ, Taylor JWet al., 2002,

    Molecular and phenotypic description of <i>Coccidioides Posadasii</i> sp nov., previously recognized as the non-California population of <i>Coccidioides immitis</i>

    , MYCOLOGIA, Vol: 94, Pages: 73-84, ISSN: 0027-5514
    • Cite
    • Citations: 379

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