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• Journal article
  Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN, Haynes K, Haas Het al., 2004,

  Siderophore biosynthesis but not reductive iron assimilation is essential for <i>Aspergillus fumigates</i> virulence

  , JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 200, Pages: 1213-1219, ISSN: 0022-1007
  • Cite
  • Citations: 427
• Journal article
  Caramori G, Adcock IM, Ito K, 2004,

  Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

  , Curr Opin Investig Drugs, Vol: 5, Pages: 1141-1147, ISSN: 1472-4472

  Nuclear factor-kappaB (NFkappaB) is an inducible transcription factor that plays a central role in the regulation of many immune and inflammatory responses. While NFkappaB is required for cell survival and immunity, abnormal expression and/or activation of NFkappaB leads to the development of many pathological states, especially those involved in chronic and acute inflammation. Many different signal transduction pathways, originating from a wide variety of cellular stresses and stimuli, converge on a single target; the NFkappaB/IkappaB complex and its activating kinase (inhibitor of kappaB kinase, IKK). Here, we review some of the major NFkappaB activating pathways, their role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD), and their potential as targets in the treatment of asthma and COPD.

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• Journal article
  Fisher MC, Aanensen D, de Hoog S, Vanittanakom Net al., 2004,

  Multilocus microsatellite typing system for <i>Penicillium marneffei</i> reveals spatially structured populations

  , JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 5065-5069, ISSN: 0095-1137
  • Author Web Link
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  • Citations: 40
• Journal article
  Gugnani H, Fisher MC, Paliwal-Johsi A, Vanittanakom N, Singh I, Yadav PSet al., 2004,

  Role of <i>Cannomys badius</i> as a natural animal host of <i>Penicillium marneffei</i> in India

  , JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 5070-5075, ISSN: 0095-1137
  • Cite
  • Citations: 46
• Journal article
  Thwaites R, Spanu PD, Panopoulos NJ, Stevens C, Mansfield JWet al., 2004,

  Transcriptional regulation of components of the type III secretion system and effectors in <i>Pseudomonas syringae</i> pv. <i>phaseolicola</i>

  , MOLECULAR PLANT-MICROBE INTERACTIONS, Vol: 17, Pages: 1250-1258, ISSN: 0894-0282
  • Cite
  • Citations: 36
• Journal article
  Davies JC, Turner MW, Klein N, 2004,

  Impaired pulmonary status in cystic fibrosis adults with two mutated <i>MBL-2</i> alleles

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 798-804, ISSN: 0903-1936
  • Author Web Link
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  • Citations: 53
• Journal article
  Donnelly LE, Newton R, Kennedy GE, Fenwick PS, Leung RHF, Ito K, Russell REK, Barnes PJet al., 2004,

  Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms

  , AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 287, Pages: L774-L783, ISSN: 1040-0605
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• Journal article
  Hayashi R, Wada H, Ito K, Adcock IMet al., 2004,

  Effects of glucocorticoids on gene transcription

  , EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 500, Pages: 51-62, ISSN: 0014-2999
  • Cite
  • Citations: 207
• Journal article
  Hay A, Barkoulas M, Tsiantis M, 2004,

  PINning down the connections: transcription factors and hormones in leaf morphogenesis

  , CURRENT OPINION IN PLANT BIOLOGY, Vol: 7, Pages: 575-581, ISSN: 1369-5266
  • Cite
  • Citations: 30
• Journal article
  Donnelly CA, Fisher MC, Fraser C, Ghani AC, Riley S, Ferguson NM, Anderson RMet al., 2004,

  Epidemiological and genetic analysis of severe acute respiratory syndrome

  , Lancet Infectious Diseases, Vol: 4, Pages: 672-683, ISSN: 1473-3099

  The severe acute respiratory syndrome (SARS) epidemics in 2002–2003 showed how quickly a novel infectious disease can spread both within communities and internationally. We have reviewed the epidemiological and genetic analyses that have been published both during and since these epidemics, and show how quickly data were collected and analyses undertaken. Key factors that determine the speed and scale of transmission of an infectious disease were estimated using statistical and mathematical modelling approaches, and phylogenetic analyses provided insights into the origin and evolution of the SARS-associated coronavirus. The SARS literature continues to grow, and it is hoped that international collaboration in the analysis of epidemiological and contact-network databases will provide further insights into the spread of this newly emergent infectious disease.

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