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  • Journal article
    Arst HN, Sheerins A, 1996,

    Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans (vol 19, pg 1019, 1996)

    , MOLECULAR MICROBIOLOGY, Vol: 20, Pages: 901-901, ISSN: 0950-382X
  • Journal article
    Langdon T, Sheerins A, Ravagnani A, Gielkens M, Caddick MX, Arst HNet al., 1996,

    Erratum: Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression (Mol Microbiol. (1995), 17 (5), 877-888)

    , Molecular Microbiology, Vol: 20, ISSN: 0950-382X
  • Journal article
    Langdon T, Sheerins A, Ravagnani A, Gielkens M, Caddick MX, Arst HNet al., 1996,

    Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression (vol 17, pg 877, 1995)

    , MOLECULAR MICROBIOLOGY, Vol: 20, Pages: 239-239, ISSN: 0950-382X
  • Journal article
    Davies J, Rosenthal M, Bush A, 1996,

    Severe small airways disease resistant to medical treatment in a child with cystic fibrosis

    , JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 89, Pages: P172-P173, ISSN: 0141-0768
  • Journal article
    Arst HN, Sheerins A, 1996,

    Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans

    , MOLECULAR MICROBIOLOGY, Vol: 19, Pages: 1019-1024, ISSN: 0950-382X
  • Journal article
    MacCabe AP, vandenHombergh JPTW, Tilburn J, Arst HN, Visser Jet al., 1996,

    Identification, cloning and analysis of the Aspergillus niger gene pacC, a wide domain regulatory gene responsive to ambient pH

    , MOLECULAR AND GENERAL GENETICS, Vol: 250, Pages: 367-374, ISSN: 0026-8925
  • Journal article
    Moffatt MF, Cookson WO, 1996,

    The genetics of specific allergy.

    , Monogr Allergy, Vol: 33, Pages: 71-96, ISSN: 0077-0760
  • Journal article
    Platt A, Langdon T, Arst HN, Kirk D, Tollervey D, Mates Sanchez JM, Caddick MXet al., 1996,

    Nitrogen metabolite signalling involves the C-terminus and the GATA domain of the Aspergillus transcription factor AREA and the 3' untranslated region of its mRNA

    , EMBO J, Vol: 15, Pages: 2791-2801
  • Journal article
    Byrne B, Fowler PA, Templeton AA, 1996,

    Gonadotrophin surge attenuating factor suppresses progesterone augmentation of GnRH priming

    , Journal of Clinical Endocrinology & Metabolism, Vol: 81, Pages: 1454-1459

    We investigated the effects of gonadotropin surge-attenuating factor (GnSAF), inhibin, and follistatin on GnRH self-priming and its augmentation by progesterone. Two GnRH challenges, 60 min apart, were administered to rat pituitary monolayers after 90-min exposure to medium alone (control), progesterone, GnSAF, inhibin, or follistatin. Inhibin-stripped follicular fluid from superovulated women was used as a source of GnSAF bioactivity. Under control conditions, the greater response to the second GnRH challenge (peak 2, 9.2 +/- 2.1; peak 1, 4.4 +/- 0.9 ng LH/mL; P < 0.01) demonstrated GnRH self-priming. None of the treatments significantly altered the first LH peak. Progesterone markedly increased GnRH self-priming (peak 2, 12.6 +/- 2.5 ng LH/mL; P < 0.01). However, GnSAF and RU486 significantly reduced GnRH self-priming (peak 2, 4.6 +/- 0.9 and 5.6 +/- 1.6 ng LH/mL, respectively; P < 0.01). The augmentation of self-priming induced by progesterone was completely abolished by coincubation with either GnSAF or RU486 (peak 2, 7.5 +/- 1.6 and 4.3 +/- 0.9 ng LH/mL, respectively; P < 0.01). Neither inhibin nor follistatin had any effect on GnRH self-priming or its augmentation by progesterone. The actions of RU486 in the presence and absence of progesterone demonstrate a nonprogestagenic effect of RU486 on the gonadotropes. In conclusion, the suppression of GnRH self-priming, with or without progesterone augmentation, supports the hypothesis that GnSAF acts by maintaining the pituitary in an unprimed state of reduced responsiveness to GnRH.
  • Journal article
    Platt A, Ravagnani A, Arst H, Kirk D, Langdon T, Caddick Met al., 1996,

    Mutational analysis of the C-terminal region of AREA, the transcription factor mediating nitrogen metabolite repression in Aspergillus nidulans

    , Molecular Gen Genet, Vol: 250, Pages: 106-114

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