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• Journal article
  Anderson GG, Leaves NI, Bhattacharyya S, Zhang YM, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WOCMet al., 2002,

  Positive association to IgE levels and a physical map of the 13q14 atopy locus

  , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 10, Pages: 266-270, ISSN: 1018-4813
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  • Citations: 23
• Journal article
  Byrne B, Iwata S, 2002,

  Membrane protein complexes

  , CURRENT OPINION IN STRUCTURAL BIOLOGY, Vol: 12, Pages: 239-243, ISSN: 0959-440X
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  • Citations: 25
• Journal article
  Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WOCMet al., 2002,

  Positive association to IgE levels and a physical map of the 13q14 atopy locus.

  , Eur J Hum Genet, Vol: 10, Pages: 266-270, ISSN: 1018-4813

  Linkage of atopy and associated traits to a locus on chromosome 13q14 has been identified by several studies in diverse populations. We have previously shown the putative atopy gene to be contained within an interval of approximately 5 Mb flanked by D13S328 and D13S1269 and centred on D13S273. We have now extended this work using a top-down approach to physical mapping. A YAC contig was constructed covering the D13S328 and D13S1269 interval. Thirty-one ESTs were mapped to the contig. We constructed a BAC and PAC contig flanking D13S273 by approximately 750 kb in either direction. The interval contained 27 of the 31 ESTS from the YAC contig. Seven previously unknown microsatellites were recovered and then typed in two subject panels. A positive association between the total serum Immunoglobulin E concentration and the novel USAT24G1 microsatellite was discovered (P(corrected)<0.005) and replicated in a second panel of families. The discovery of a region of positive association within the BAC/PAC contig will permit identification of the atopy gene from this locus.

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• Journal article
  Díez E, Alvaro J, Espeso EA, Rainbow L, Suárez T, Tilburn J, Arst HN, Peñalva MAet al., 2002,

  Activation of the <i>Aspergillus</i> PacC zinc finger transcription factor requires two proteolytic steps

  , EMBO JOURNAL, Vol: 21, Pages: 1350-1359, ISSN: 0261-4189
  • Author Web Link
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  • Citations: 112
• Journal article
  Jormakka M, Törnroth S, Byrne B, Iwata Set al., 2002,

  Molecular basis of proton motive force generation:: Structure of formate dehydrogenase-N

  , SCIENCE, Vol: 295, Pages: 1863-1868, ISSN: 0036-8075
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  • Citations: 410
• Conference paper
  Cookson WOC, 2002,

  Asthma genetics

  , 44th Annual Thomas L Petty Aspen Lung Conference, Publisher: ELSEVIER, Pages: 7S-13S, ISSN: 0012-3692
  • Cite
  • Citations: 66
• Journal article
  Leaves NI, Bhattacharyya S, Wiltshire S, Cookson WOCMet al., 2002,

  A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus.

  , Eur J Hum Genet, Vol: 10, Pages: 177-182, ISSN: 1018-4813

  Non-specific bronchial hyper-responsiveness to various inhaled stimuli is a characteristic of asthma. We have previously shown linkage of bronchial responsiveness to methacholine (measured as dose-response slope (DRS)) and the peripheral blood eosinophil count (EOS) to chromosome 7. We have now further investigated these linkages by genotyping 49 microsatellite markers across the DRS locus on chromosome 7. The markers were spaced on average 2.6 cM apart and spanned a sex averaged cumulative genetic distance of 129 cM. Multipoint linkage to DRS was bimodal and dipped at the centromere. The two peaks of linkage were close to markers D7S484 (P=0.0003) and D7S669 (P=0.006) respectively. Separate testing for linkage to paternally and maternally derived alleles showed that the linkage near D7S484 was paternally derived (P<0.00001): maternally derived alleles did not exhibit significant linkage. The results indicate that two disparate loci may be influencing asthma from chromosome 7.

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• Journal article
  Bidartondo MI, Bruns TD, 2002,

  Fine-level mycorrhizal specificity in the Monotropoideae (Ericaceae): specificity for fungal species groups.

  , Molecular Ecology, Vol: 11, Pages: 557-569, ISSN: 0962-1083

  The Monotropoideae (Ericaceae) are non-photosynthetic angiosperms that obtain fixed carbon from basidiomycete ectomycorrhizal fungi. In previous work, we showed that each plant species is associated with a single genus or a set of closely related genera of ectomycorrhizal fungi. Here we show that the level of specificity is much higher. We used a molecular phylogenetic approach to contrast specificity patterns among eight plant lineages and three fungal genera. We relied on fungal nuclear internal transcribed spacer (nrITS) sequence data obtained from 161 basidiocarps and 85 monotropoid roots representing 286 sampled plants screened using restriction length polymorphisms. From the phylogenetic placement of fungal symbionts in fungal phylograms, we found that three basal (Sarcodes, Pterospora, Pleuricospora) and one derived lineage (Allotropa) of plants target narrow clades of closely related species groups of fungi, and four derived lineages (Monotropa hypopithys species group, Pityopus) target more distant species groups. Within most plant lineages, geography and photobiont association constrain specificity. Specificity extended further in Pterospora andromedea, in which sequence haplotypes at the plastid trn L-F region of 73 plants were significantly associated with different fungal species groups even in sympatry. These results indicate that both the macro- and microevolution of the Monotropoideae are tightly coupled to their mycorrhizal symbionts.

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• Journal article
  Leaves NI, Bhattacharyya S, Wiltshire S, Cookson WOCMet al., 2002,

  A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus

  , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 10, Pages: 177-182, ISSN: 1018-4813
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  • Citations: 14
• Journal article
  Bismarck A, Menner A, Kumru ME, Saraç AS, Bistritz M, Schulz Eet al., 2002,

  Poly(carbazole-co-acrylamide) electrocoated carbon fibers and their adhesion behavior to an epoxy resin matrix

  , JOURNAL OF MATERIALS SCIENCE, Vol: 37, Pages: 461-471, ISSN: 0022-2461
  • Author Web Link
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  • Citations: 32

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