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  • Journal article
    van Hage-Hamsten M, Johansson E, Kronqvist M, Loughry A, Cookson WOCM, Moffatt MFet al., 2002,

    Associations of FcεR1-β polymorphisms with immunoglobin E antibody responses to common inhalant allergens in a rural population

    , CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 32, Pages: 838-842, ISSN: 0954-7894
  • Journal article
    Davies JC, 2002,

    Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence.

    , Paediatr Respir Rev, Vol: 3, Pages: 128-134, ISSN: 1526-0542

    Pseudomonas aeruginosa is the major pathogen in the cystic fibrosis (CF) lung. Prevalence is high and, once acquired, chronic infection will almost always ensue. Several hypotheses related to the underlying molecular defects in CF have been suggested to explain this high rate of prevalence. These include abnormalities of airway surface liquid leading to impaired mucociliary clearance or malfunction of antibacterial peptides, increased availability of bacterial receptors, reduced ingestion of pathogens by CF cells and impaired defence related to low levels of molecules such as nitric oxide or glutathione. Further work is needed to identify which of these mechanisms is important in the early stages of infection. Once the organisms have gained a foothold in the CF airway they have a wide array of properties that enhance their survival and allow them to evade host defences and antibiotic agents successfully. Conversion to mucoidy and the formation of biofilms are two of the main mechanisms by which this is achieved. Understanding the steps involved in both initial infection and in establishing chronicity may help in the development of new treatment strategies.
  • Journal article
    Uehara Y, Iida T, Ito KJ, Iwami M, Ushioda Set al., 2002,

    Optical observation of single-electron charging effect in metallic particles - art. no. 155408

    , PHYSICAL REVIEW B, Vol: 65, ISSN: 2469-9950
  • Conference paper
    Bruns TD, Bidartondo MI, Taylor DL, 2002,

    Host specificity in ectomycorrhizal communities: What do the exceptions tell us?

    , Integrative and Comparative Biology, Pages: 352-359, ISSN: 1540-7063
  • Journal article
    Anderson GG, Leaves NI, Bhattacharyya S, Zhang YM, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WOCMet al., 2002,

    Positive association to IgE levels and a physical map of the 13q14 atopy locus

    , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 10, Pages: 266-270, ISSN: 1018-4813
    • Cite
    • Citations: 23
  • Journal article
    Byrne B, Iwata S, 2002,

    Membrane protein complexes

    , CURRENT OPINION IN STRUCTURAL BIOLOGY, Vol: 12, Pages: 239-243, ISSN: 0959-440X
    • Cite
    • Citations: 25
  • Journal article
    Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WOCMet al., 2002,

    Positive association to IgE levels and a physical map of the 13q14 atopy locus.

    , Eur J Hum Genet, Vol: 10, Pages: 266-270, ISSN: 1018-4813

    Linkage of atopy and associated traits to a locus on chromosome 13q14 has been identified by several studies in diverse populations. We have previously shown the putative atopy gene to be contained within an interval of approximately 5 Mb flanked by D13S328 and D13S1269 and centred on D13S273. We have now extended this work using a top-down approach to physical mapping. A YAC contig was constructed covering the D13S328 and D13S1269 interval. Thirty-one ESTs were mapped to the contig. We constructed a BAC and PAC contig flanking D13S273 by approximately 750 kb in either direction. The interval contained 27 of the 31 ESTS from the YAC contig. Seven previously unknown microsatellites were recovered and then typed in two subject panels. A positive association between the total serum Immunoglobulin E concentration and the novel USAT24G1 microsatellite was discovered (P(corrected)<0.005) and replicated in a second panel of families. The discovery of a region of positive association within the BAC/PAC contig will permit identification of the atopy gene from this locus.
  • Journal article
    Díez E, Alvaro J, Espeso EA, Rainbow L, Suárez T, Tilburn J, Arst HN, Peñalva MAet al., 2002,

    Activation of the <i>Aspergillus</i> PacC zinc finger transcription factor requires two proteolytic steps

    , EMBO JOURNAL, Vol: 21, Pages: 1350-1359, ISSN: 0261-4189
  • Journal article
    Jormakka M, Törnroth S, Byrne B, Iwata Set al., 2002,

    Molecular basis of proton motive force generation:: Structure of formate dehydrogenase-N

    , SCIENCE, Vol: 295, Pages: 1863-1868, ISSN: 0036-8075
  • Conference paper
    Cookson WOC, 2002,

    Asthma genetics

    , 44th Annual Thomas L Petty Aspen Lung Conference, Publisher: ELSEVIER, Pages: 7S-13S, ISSN: 0012-3692
    • Cite
    • Citations: 66

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