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Journal articleHamada W, Spanu PD, 1998,
Co-suppression of the hydrophobin gene <i>HCf-1</i> is correlated with antisense RNA biosynthesis in <i>Cladosporium fulvum</i>
, MOLECULAR AND GENERAL GENETICS, Vol: 259, Pages: 630-638, ISSN: 0026-8925- Author Web Link
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- Citations: 32
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Journal articleDenison SH, Negrete-Urtasun S, Mingot JR, et al., 1998,
Putative membrane components of signal transduction pathways for ambient pH regulation in <i>Aspergillus</i> and meiosis in <i>Saccharomyces</i> are homologous
, MOLECULAR MICROBIOLOGY, Vol: 30, Pages: 259-264, ISSN: 0950-382X- Author Web Link
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- Citations: 56
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Journal articleByrne B, Klahn S, Taylor PL, et al., 1998,
Functional analysis of GnRH receptor ligand binding using biotinylated GnRH derivatives
, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 144, Pages: 11-19, ISSN: 0303-7207- Author Web Link
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- Citations: 4
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Journal articleWilson RA, Arst HN, 1998,
Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors.
, Microbiol Mol Biol Rev, Vol: 62, Pages: 586-596, ISSN: 1092-2172The transcriptional activator AREA is a member of the GATA family of transcription factors and mediates nitrogen metabolite repression in the fungus Aspergillus nidulans. The nutritional versatility of A. nidulans and its amenability to classical and reverse genetic manipulations make the AREA DNA binding domain (DBD) a useful model for analyzing GATA family DBDs, particularly as structures of two AREA-DNA complexes have been determined. The 109 extant mutant forms of the AREA DBD surveyed here constitute one of the highest totals of eukaryotic transcription factor DBD mutants, are discussed in light of the roles of individual residues, and are compared to corresponding mutant sequence changes in other fungal GATA factor DBDs. Other topics include delineation of the DBD using both homology and mutational truncation, use of frameshift reversion to detect regions of tolerance to mutational change, the finding that duplication of the DBD can apparently enhance AREA function, and use of the AREA system to analyze a vertebrate GATA factor DBD. Some major points to emerge from work on the AREA DBD are (i) tolerance to sequence change (with retention of function) is surprisingly great, (ii) mutational changes in a transcription factor can have widely differing, even opposing, effects on expression of different structural genes so that monitoring expression of one or even several structural genes can be insufficient and possibly misleading, and (iii) a mutational change altering local hydrophobic packing and DNA binding target specificity can markedly influence the behavior of mutational changes elsewhere in the DBD.
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Journal articleWilson RA, Arst HN, 1998,
Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in <i>Aspergillus nidulans</i> and a member of the "streetwise" GATA family of transcription factors
, MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Vol: 62, Pages: 586-+, ISSN: 1092-2172- Author Web Link
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- Citations: 103
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Journal articleMoffatt MF, Cookson WO, 1998,
Gene identification in asthma and allergy.
, Int Arch Allergy Immunol, Vol: 116, Pages: 247-252, ISSN: 1018-2438Asthma and atopy are due to the interaction between genetic and environmental factors. The genetic basis of asthma and atopy is becoming more certain, with the promise of improvements in the diagnosis and treatment of these disorders. A combination of candidate gene and positional cloning studies has already identified several genes which influence allergic disease. These genes predispose in general to atopy, or influence the specific IgE response to individual allergens, or enhance inflammation independently of atopic mechanisms. In addition to these known factors, the chromosomal localisation of other putative genes is becoming clear.
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Journal articleDavies JC, Geddes DM, Alton EWFW, 1998,
Prospects for gene therapy for cystic fibrosis
, MOLECULAR MEDICINE TODAY, Vol: 4, Pages: 292-299, ISSN: 1357-4310- Author Web Link
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- Citations: 18
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Journal articleKarpovich-Tate N, Spanu P, Dewey FM, 1998,
Use of monoclonal antibodies to determine biomass of <i>Cladosporium fulvum</i> in infected tomato leaves
, MOLECULAR PLANT-MICROBE INTERACTIONS, Vol: 11, Pages: 710-716, ISSN: 0894-0282- Author Web Link
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- Citations: 27
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Journal articleHensel M, Arst HN, Aufauvre-Brown A, et al., 1998,
The role of the <i>Aspergillus fumigatus areA</i> gene in invasive pulmonary aspergillosis
, MOLECULAR AND GENERAL GENETICS, Vol: 258, Pages: 553-557, ISSN: 0026-8925- Author Web Link
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- Citations: 79
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Journal articleCookson WO, Moffatt MF, 1998,
Alchemy for asthma.
, Nat Med, Vol: 4, Pages: 500-501, ISSN: 1078-8956
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