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• Thesis dissertation
  Georgiadis A, 2001,

  Interfacial Tension of Aqueous and Hydrocarbon Systems in the Presence of Carbon Dioxide at Elevated Pressures and Temperatures

  The interfacial tension of partially miscible phases, containing H2O andhydrocarbons in the presence of CO2 at elevated pressures and temperatures,has been studied within the context of producing cleaner fossil fuelsby simultaneously tackling greenhouse gas emissions. This is a most relevantproperty inuencing the multiphase reservoir ows associated withenhanced oil recovery (EOR), and carbon capture and storage (CCS). Themain core of the thesis focuses on the experimental investigation of thedependence of interfacial tension on pressure and temperature, for variousmixtures of pure substances relevant to oil- eld conditions and uids. Forthis purpose, a high pressure high temperature (HPHT) apparatus, comprisinga view cell, high pressure capillary tubing connections, and appropriateuid delivery syringe pumps, was used over an operating temperaturerange of (298 to 473)K and at pressures up to 60MPa. The apparatusimplemented the pendant drop method, well suited for the accuratedetermination of uid/liquid interfacial tensions at elevated pressures andtemperatures, linked to a computer-aided drop shape analysis (DSA) system.Measurements were made over a wide range of conditions for the twophasesystems (H2O+CO2), (n-decane+CO2), (n-dodecane+CO2), (n-hexadecane+CO2), (H2O+n-decane) and (H2O+[n-decane+CO2]). Thedi erent isotherms recorded for each system demonstrated systematic trendswith increasing pressure, while the decrease of interfacial tension with temperatureobserved at ambient pressures was usually reversed at elevatedpressures. For the (H2O+CO2) system in particular, the pressure dependenceof interfacial tension demonstrated abrupt changes at certain conditions,associated with the onset of the liquid or supercritical states, abovewhich the interfacial tension was less sensitive to changes in both pressureand temperature. This was not the case for the (n-alkane+CO2) systems,where the interfacial tension reduced with increasing pressure, vanishing asthe two phases be

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• Journal article
  Davies JC, Geddes DM, Alton EW, 2001,

  Prospects for gene therapy in lung disease.

  , Curr Opin Pharmacol, Vol: 1, Pages: 272-277, ISSN: 1471-4892

  The past decade has brought significant advances in the field of gene therapy for both inherited and acquired diseases, especially with regard to respiratory disease. Barriers to gene transfer posed by the lung have led to the development of modifications of both vector and host in an attempt to increase the efficiency of transfer. Recently, progress has been made in both laboratory and clinical studies of gene therapy for cystic fibrosis, alpha1-antitrypsin deficiency and lung cancer.

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• Journal article
  Abecasis GR, Cookson WO, Cardon LR, 2001,

  The power to detect linkage disequilibrium with quantitative traits in selected samples.

  , Am J Hum Genet, Vol: 68, Pages: 1463-1474, ISSN: 0002-9297

  Results from power studies for linkage detection have led to many ongoing and planned collections of phenotypically extreme nuclear families. Given the great expense of collecting these families and the imminent availability of a dense diallelic marker map, the families are likely to be used in allelic-association as well as linkage studies. However, optimal selection strategies for linkage may not be equally powerful for association. We examine the power to detect linkage disequilibrium for quantitative traits after phenotypic selection. The results encompass six selection strategies that are in widespread use, including single selection (two designs), affected sib pairs, concordant and discordant pairs, and the extreme-concordant and -discordant design. Selection of sibships on the basis of one extreme proband with high or low trait scores provides as much power as discordant sib pairs but requires the screening and phenotyping of substantially fewer initial families from which to select. Analysis of the role of allele frequencies within each selection design indicates that common trait alleles generally offer the most power, but similarities between the marker- and trait-allele frequencies are much more important than the trait-locus frequency alone. Some of the most widespread selection designs, such as single selection, yield power gains only when both the marker and quantitative trait loci (QTL) are relatively rare in the population. In contrast, discordant pairs and the extreme-proband design provide power for the broadest range of QTL-marker-allele frequency differences. Overall, proband selection from either tail provides the best balance of power, robustness, and simplicity of ascertainment for family-based association analysis.

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• Journal article
  Bidartondo MI, Baar J, Bruns TD, 2001,

  Low ectomycorrhizal inoculum potential and diversity from soils in and near ancient forests of bristlecone pine (Pinus longaeva)

  , Canadian Journal of Botany, Vol: 79, Pages: 293-299, ISSN: 0008-4026

  Intersite variation in ectomycorrhizal (ECM) inoculum potential in soils from 16 sites located in arid subalpine areas of the White Mountains of California was quantified. The study sites included valleys dominated by big sagebrush (Artemisia tridentata Nutt.) and mountainsides dominated by ancient Great Basin bristlecone pine (Pinus longaeva Bailey). ECM inoculum potential was not detected at three of four valley sites nor in 42% of forest soil samples. Only 10 mycorrhizal species were detected in bioassays, and four of those accounted for 94.5% of all colonized seedlings, in order of decreasing abundance these were Pyronemataceae sp., Rhizopogon sp., Wilcoxina rehmii Yang & Korf, and Cenococcum sp. These species were identified also from in situ mycorrhizal roots. The abundance of the dominant Pyronemataceae sp. was significantly positively correlated with pH, which at all forest sites was high compared with typical conifer forest soils. Our results show that the ECM inoculum potential of soils is low, homogeneous, and spatially restricted in these ancient high-elevation forests.

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  • Citations: 40
• Journal article
  Nagasawa T, Kudo N, Hida Y, Ito K, Ohba Yet al., 2001,

  Syntheses of chiral solid catalysts using menthol and application to the asymmetric Dials-Alder reaction

  , BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Vol: 74, Pages: 989-990, ISSN: 0009-2673
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  • Citations: 3
• Journal article
  Moffatt MF, Schou C, Faux JA, Abecasis GR, James A, Musk AW, Cookson WOCMet al., 2001,

  Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample

  , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 9, Pages: 341-346, ISSN: 1018-4813
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  • Citations: 61
• Journal article
  Fisher MC, Koenig GL, White TJ, San-Blas G, Negroni R, Alvarez IG, Wanke B, Taylor JWet al., 2001,

  Biogeographic range expansion into South America by <i>Coccidioides immitis</i> mirrors New World patterns of human migration

  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 98, Pages: 4558-4562, ISSN: 0027-8424
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  • Citations: 173
• Journal article
  Palmer LJ, Barnes KC, Burton PR, Chen H, Cookson WOCM, Deichmann KA, Elston RC, Holloway JW, Jacobs KB, Laitinen T, Wjst Met al., 2001,

  Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region

  , HUMAN MOLECULAR GENETICS, Vol: 10, Pages: 891-899, ISSN: 0964-6906
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  • Citations: 15
• Journal article
  Whiteford JR, Spanu PD, 2001,

  The hydrophobin HCf-1 of <i>Cladosporium fulvum</i> is required for efficient water-mediated dispersal of conidia

  , FUNGAL GENETICS AND BIOLOGY, Vol: 32, Pages: 159-168, ISSN: 1087-1845
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  • Citations: 46
• Journal article
  Cookson WO, Ubhi B, Lawrence R, Abecasis GR, Walley AJ, Cox HE, Coleman R, Leaves NI, Trembath RC, Moffatt MF, Harper JIet al., 2001,

  Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.

  , Nat Genet, Vol: 27, Pages: 372-373, ISSN: 1061-4036

  We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.

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