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• Journal article
  Arst HN, 2000,

  Apathy rewards misconduct - and everybody suffers

  , NATURE, Vol: 403, Pages: 478-478, ISSN: 0028-0836
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  • Citations: 1
• Journal article
  Marshall RP, Puddicombe A, Cookson WO, Laurent GJet al., 2000,

  Adult familial cryptogenic fibrosing alveolitis in the United Kingdom.

  , Thorax, Vol: 55, Pages: 143-146, ISSN: 0040-6376

  BACKGROUND: Familial cases of cryptogenic fibrosing alveolitis (CFA) have previously been reported; however, the prevalence and genetic background of this disorder are not known. The clinical and epidemiological findings of 25 families identified within the UK are reported. METHODS: Adult pulmonary physicians in the UK were asked to identify all families under their care in which two or more individuals had been diagnosed with fibrosing alveolitis of unknown cause. A detailed structured questionnaire was sent to each proband to delineate possible environmental/occupational exposures and to obtain complete pedigree data. Physicians were also asked to provide clinical and diagnostic information. RESULTS: Twenty five families were identified comprising 67 cases. Suitable data for analysis were available for 21 families (57 cases). The male:female ratio was 1. 75:1 (p<0.05). A high resolution computed tomographic (HRCT) scan was performed in 93% and a diagnosis of CFA confirmed on biopsy specimens in 32%. The mean age at diagnosis was 55.5 (2.5) years. Fifty percent of cases were ever smokers and 18% had been diagnosed as asthmatic. Exposure to known fibrogenic agents was recorded by 36% of patients. Clinical signs/symptoms and histological findings were indistinguishable from non-familial cases. CONCLUSIONS: This study represents the largest cohort of familial CFA cases reported to date and confirms a prevalence of 1.34 cases per 10(6) in the UK population. Although rare, such cases represent an important subgroup in which a genetic susceptibility to pulmonary fibrosis is particularly evident. Familial patients are younger at diagnosis but otherwise indistinguishable from non-familial cases. The mode of inheritance is as yet unclear but a number of genetic loci are likely to be involved and are the subject of ongoing studies.

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• Journal article
  Fisher MC, Koenig GL, White TJ, Taylor JWet al., 2000,

  Pathogenic clones versus environmentally driven population increase: Analysis of an epidemic of the human fungal pathogen <i>Coccidioides immitis</i>

  , JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 38, Pages: 807-813, ISSN: 0095-1137
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  • Citations: 74
• Journal article
  Abecasis GR, Cookson WO, 2000,

  GOLD--graphical overview of linkage disequilibrium.

  , Bioinformatics, Vol: 16, Pages: 182-183, ISSN: 1367-4803

  SUMMARY: We describe a software package that provides a graphical summary of linkage disequilibrium in human genetic data. It allows for the analysis of family data and is well suited to the analysis of dense genetic maps. AVAILABILITY: http://www.well.ox.ac.uk/asthma/GOLD CONTACT: goncalo@well.ox.ac.uk

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• Journal article
  Chaure P, Gurr SJ, Spanu P, 2000,

  Stable transformation of <i>Erysiphe graminis</i>, an obligate biotrophic pathogen of barley

  , NATURE BIOTECHNOLOGY, Vol: 18, Pages: 205-207, ISSN: 1087-0156
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  • Citations: 63
• Journal article
  Paterson S, Fisher MC, Viney ME, 2000,

  Inferring infection processes of a parasitic nematode using population genetics

  , PARASITOLOGY, Vol: 120, Pages: 185-194, ISSN: 0031-1820
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  • Citations: 13
• Journal article
  Hamill SJ, Cota E, Chothia C, Clarke Jet al., 2000,

  Conservation of folding and stability within a protein family: The tyrosine corner as an evolutionary cul-de-sac

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 295, Pages: 641-649, ISSN: 0022-2836
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  • Citations: 95
• Journal article
  Greene DR, Koenig G, Fisher MC, Taylor JWet al., 2000,

  Soil isolation and molecular identification of <i>Coccidioides immitis</i>

  , MYCOLOGIA, Vol: 92, Pages: 406-410, ISSN: 0027-5514
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  • Citations: 74
• Journal article
  Cookson WOC, Moffatt MF, 2000,

  Genetics of asthma and allergic disease

  , Human Molecular Genetics, Vol: 9, Pages: 2359-2364, ISSN: 0964-6906

  Atopic (allergic) asthma is the most common disease of childhood and is strongly genetic in origin. Many genome-wide screens for asthma and its associated traits have now been carried out, and genetic linkage has been consistently identified in several regions. It is probable that these loci contain major genes influencing atopy and asthma. Candidate genes have already been identified from the cytokine cluster on chromosome 5 and the MHC on chromosome 6. These complex regions contain more than one susceptibility locus for allergic disease. Other regions do not contain obvious candidate genes, and positional cloning of these loci is likely to identify novel disease pathways. Parent-of-origin effects are prominent at some of the loci and some also show linkage to other inflammatory immune diseases. Several single gene disorders are associated with allergic disease and on occasion are also linked to the same chromosomal regions. The positional cloning of asthma genes is now feasible.

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  • Citations: 139
• Journal article
  Sanderson E, Desai SR, 2000,

  Non-vascular thoracic intervention

  , Imaging, Vol: 12, Pages: 178-192, ISSN: 0965-6812

  · Radiologically guided percutaneous needle biopsy is a safe and well tolerated procedure, which can often be performed as an outpatient procedure. · Transthoracic needle biopsy is most effective in the diagnosis of malignancy, but has limitations since the likelihood of obtaining a specific benign diagnosis is often low. · Percutaneous image-guided aspiration and drainage are fast becoming the ″first line″ treatments for the management of pleural and mediastinal collections; percutaneous drainage of lung abscess is an acceptable alternative to surgery where medical therapy has failed. · Tracheobronchial stenting is a valuable (often palliative) technique in the management of airway narrowing.

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